Circulation
Articles in this Issue
Abstract 4369451: Critical window post-stroke is influenced by biological sex in mice
Sex differences in stroke outcomes are well documented, but it is unknown how males and females differ in their timing and duration of the critical window– a limited period of heightened plasticity wh...
Abstract 4358317: Emergence of Hypertension in Thyroid Cancer Patients on BRAF ± MEK Inhibitors: A Closer Look at Incidence and Contributing Risk Factors
Background: Inhibitors of BRAF (BRAFi) and MEK (MEKi) are often used in advanced BRAF V600E...
Abstract 4357831: Sacubitril/Valsartan in Resistant Hypertension: Longitudinal Improvements in Blood Pressure Control Accompanied by Increasing Adverse Event Rates
Background: Despite multidrug therapy, blood pressure control remains suboptimal in resistant hypertension, prompting evaluation of sacubitril/valsartan as an adjunct....
Abstract 4367635: Obesity and Causes of Community Sudden Death by Autopsy: From The San Francisco Postmortem Systematic Investigation Of Sudden Cardiac Death Study
Background: Studies have reported association between obesity and sudden cardiac death (SCD) but presume cardiac cause without autopsy. Elucidating causes of SCD by weight status m...
Abstract 4365286: Association of Sleep Temperature Patterns with Resting Heart Rate in Regular and Irregular Menstrual Cycles using Wearables: a real-world cross-sectional study
Background: Temperature, heart rate (HR) and heart rate variability (HRV) are known to be hormonally influenced and fluctuate across the menstrual cycle. However, the association o...
Abstract 4367664: Glycated Hemoglobin Predicts the Presence of High-Risk Coronary Plaque on Coronary Computed Tomographic Angiography (CCTA) in Patients without Diabetes
Introduction: A substantial risk gradient for incident cardiovascular disease has been seen across glycated hemoglobin (HbA 1c ) levels belo...
Abstract 4370894: The Growing Cardiopulmonary Crisis: Global Trends in Heart Failure Due to Chronic Respiratory Diseases (1990–2021)
Background: Heart failure (HF) poses a substantial and rising global burden, driving disability and healthcare costs across regions. While ischemic heart disease and hypertension a...
Abstract 4343901: Overall and Gender Trends in Chronic Kidney Disease and Ischemic Heart Disease-related Deaths: Insights from CDC WONDER (1999–2020)
Background: Ischemic heart disease is a significant cause of mortality among adult patients suffering from chronic renal failure in the United States. This study investigates trend...
Abstract 4344150: Perinatal PM2.5 Exposure Varies by Race and Ethnicity but Does Not Mediate Disparities in Infant Cardiac Surgery Outcomes: A Causal Mediation Analysis
Introduction: Racial and ethnic disparities in congenital heart surgery outcomes are well documented and attributed to social determinants, but the full range of contributing facto...
Abstract Sat807: Distinct Strategies For Increasing Or Withholding Bystander Cardiopulmonary Resuscitation For Older Patients With Out-of-hospital Cardiac Arrest Stratified By Bystander Type And Age
Background: In older patients with out-of-hospital cardiac arrest (OHCA), the neurological outcome could differ based on bystander type and age....
Abstract 4347786: Targeting the interleukin-33/ST2 Pathway Attenuates Coronary Arteritis in a Murine Model of Kawasaki Disease
Background: Kawasaki disease (KD) is a systemic vasculitis that primarily affects young children and can result in coronary artery sequelae. The innate immune system plays an essen...
Abstract 4372935: Efficacy evaluation of the novel concave supra-aortic branched stent-graft system and optimization scenarios for patient-specific endovascular total arch repair via hemodynamics
Introduction: Concave supra-aortic branched stent-graft (CSBSG) system offers a new option for managing aortic arch pathologies. However, therapeutic efficacy and appropriate impla...
Abstract 4362117: DSI-phering Signals: Unlocking Prognostic Clues in Cardiogenic Shock
Background: Vasoplegia presents as diastolic hypotension and tachycardia. Increasing values of the diastolic shock index (DSI), defined as the ratio between heart rate and diastoli...
Abstract 4345297: Enhancing Lipid Management in Veterans: Integrating Whole Health Principles through the VALOR-QI Program and Veterans Health Administration
Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality among U.S. Veterans, with uncontrolled low-density lipoprotein cholesterol (LDL-C) contributing to adverse outcomes. The...
Abstract 4346854: Intensive Blood Pressure Control and SGLT2 Inhibitors for the PREVENTion of Heart Failure: The Multi-Ethnic Study of Atherosclerosis
Background: Intensive systolic blood pressure (SBP) lowering and sodium-glucose cotransport-2 inhibitor (SGLT2i) treatment can reduce the risk of incident heart failure (HF)....
Abstract 4366881: Clinical and Echocardiographic Correlates of Persistent Left Ventricle Dysfunction in Peripartum Cardiomyopathy: Insights from the Italian Multicentre Registry
Background: Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening form of heart failure (HF) occurring toward the end of pregnancy or early after delivery wit...
Abstract 4359975: The Impact of Patient-Physician Characteristics on Diabetes Care Adherence
Background: Diabetes affects 14.7% of adults in the US, contributing to health and economic burdens, with persistent differences in prevalence by race and ethnicity. Prior research...
Abstract Sun207: Upregulated Bach1 aggreaviated brain injury after cardiopulmonary resuscitation in mice through enhancing brain microvascular endothelial cell endocytosis
Background: Persistent cognitive impairment and anxiety-depressive states occur in 20-30% of return of spontaneous circulation (ROSC) patients, manifesting as diffuse cerebral edem...
Abstract 4368598: Nutrition in the Cardiac Intensive Care Unit: Insights from a Survey of the Critical Care Cardiology Trials Network
Background: Nutrition is a vital component of recovery for critically ill cardiac patients. However, there is a substantial lack of evidence, consensus, and guidelines regarding op...
Abstract 4361091: Milrinone Associated with Lower Mortality and Higher Arrhythmia Risk in Comparison to Dobutamine in End-Stage Heart Failure Without Renal Dysfunction
Introduction: Milrinone and dobutamine are commonly used inotropes for advanced heart failure, but comparative data in patients without renal dysfunction are limited. Prior studies...
Abstract 4365038: Decreased Nocturnal Very Low Frequency of Heart Rate Variability Linked to Adverse Cardiovascular Events in Patients with Hypertension
Background: Evaluating nocturnal regulation of cardiac autonomic nervous system (CANS) with frequency-domain heart rate variability (HRV) is relevant, especially in patients with s...
Abstract 4369636: Multi-parametric Cardiac MRI predicts cardiovascular outcomes in HTx recipients after long-term follow-up
Background: The long-term survival of heart transplantation (HTx) recipients is influenced by a range of cardiovascular, immunological, and procedural factors. Accurately predictin...
Abstract 4358285: In-Hospital Outcomes of Acute Heart Failure Subtypes in Patients with Breast Cancer: A Nationwide Analysis
Background: Breast cancer (BC) is the most common cause of cancer-related mortality among women. Despite advancements in treatment and longer survival, BC patients are at a higher...
Abstract 4370892: Fast Removal of Impulsive Noise from High-Frequency Central Venous Pressure Signals
Background: Central venous catheter (CVC)-related venous thromboembolism (VTE) is a common complication in the pediatric cardiac intensive care unit (PCICU), with the incidence rat...
Abstract 4371168: Comparative Outcomes of GLP-1 Agonists vs SGLT2 Inhibitors in Patients with Type 2 Diabetes and Heart Failure: A Propensity-Matched Multicenter Retrospective Analysis
Introduction: Although both SGLT2 inhibitors and GLP-1 agonists have shown cardiovascular benefits in patients with type 2 diabetes mellitus (T2DM), their comparative effectiveness...