Angewandte Chemie International Edition
Articles in this Issue
A Multifunctional Polyester Nanoplatform for the Synergistic Anticancer: Enhanced Photodynamic Therapy and Targeted Gene Silencing
Abstract Gene therapy (GT) and photodynamic therapy (PDT) present promising approaches for cancer treatment. However, GT is frequently impeded by the lysosomal c...
Redox‐Driven In Situ Formation of Bimetallic Catalysts via Sn <sup>2+</sup> /Sn <sup>4+</sup> Interconversion
Abstract Bimetallic catalysts have garnered substantial interest across diverse fields due to their distinctive geometric and electronic structures. Nevertheless...
Chlorine Radical‐Mediated Photocatalytic C─C Coupling of Methanol to Ethylene Glycol with Near‐Unity Selectivity
Abstract The selective activation of inert C─H bonds in methanol under mild conditions to synthesize high‐value C 2 produ...
Direct Activation of Sulfides by C–H Oxidation with Photoexcited Nitroarenes: Formal Manipulations of the C─S Bond
Abstract The sulfide motif is distributed widely across chemical and biological space. In synthesis, its installation often marks the end point of a sequence, due to its relative ine...
Overcoming Photochemical Limitations in Covalent Organic Frameworks: Low‐Energy Light Driven Selective <sup>1</sup> O <sub>2</sub> Generation Achieved by Donor–Acceptor Strategy
Abstract Singlet oxygen ( 1 O 2 ) plays a crucial role in various photocatalytic...
High‐Rate CO <sub>2</sub> ‐to‐CH <sub>4</sub> Photoreduction by Dual‐Proton Hydrogenation Pathway Over Pd‐Anchored Oxygen‐Deficient ZnO Nanosheets
Abstract Photoreduction of CO 2 into CH 4 usually comprises upto eight proton‐cou...
Chemical Coordination Induced Fullerene Dimers on Hot Pt(111)
Abstract The fullerene family is known for its unique properties, facilitating the formation of large, lubricated nano‐onions and the fragmentation into small carbon clusters through...
Multipath ROS Storm and Immune Activation via Sulfur Vacancy‐Optimized ZnIn <sub>2</sub> S <sub>4</sub> Nanosheets for Piezocatalytic Tumor Therapy
Abstract Piezocatalytic therapy is a novel therapeutic strategy that uses mechanical energy to drive catalytic reactions to generate cytotoxic reactive oxygen sp...
Complex Donuts: Small Variations in DNA Sequence Dictate Pathway Complexity in DNA Nanotoroids
Abstract The formation of higher‐order structures in natural biopolymers, such as polypeptides and nucleic acids, is governed by sequence specificity and monomer chemistry. Although...
HCl Intake via Nanobubbles Induces Redox Radicals for Aqueous Cl <sub>2</sub> and H <sub>2</sub> Production Without Catalyst and Bias Applied
Abstract Bubbling is a widely used method to enhance gas hydration and dissolution in aqueous solutions. Understanding the bubble‐induced interface‐rich aqueous...
Supramolecular Host–Guest Assemblies for Tunable and Modular Lysosome‐Targeting Protein Degradation
Abstract Heterobifunctional drugs have revolutionized chemical biology and therapeutic innovation, yet their fixed covalent linkages constrain dynamic adaptability. Here, we introduc...
Intriguing Reactivity of a 1,2‐Dihydrodialumane Towards Organic Azides – From a Terminal Diazido–Dialumane to <i>Pendulum‐Clock‐Like</i> Azide Bridging
Abstract The reactivity of dihydro‐dialane with organic azides is described. Treatment of the hybrid ligand‐based dialane [(DNI{H}Al) 2...
Regulating Structures and Properties of Overcrowded‐Ethylene Decorated (Diaza)Phosphinines via Tunable Main‐Group Element Hyperconjugation
Abstract Creating more sophisticated molecular systems that are responsive, dynamic, and controllable through a combination of chemical structure modification and external stimuli re...
Mixed‐Metal Ce‐Zr‐Mn Clusters as Photo‐Catalysts for Decarboxylative Functionalization of Carboxylic Acids
Abstract Decarboxylative hydrazination of carboxylic acids was achieved using a 1:5:2 ratio of three metal salts, Ce(O...
Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H <sub>3</sub> PO <sub>4</sub> in Aqueous Media
Abstract Disclosed here is the first catalytic enantioselective electrochemical oxidative rearrangement of indoles for the efficient synthesis of highly enantioe...
Coordinative Ring‐Opening Polymerization of Limonene Carbamate Toward Phosgene‐ and Isocyanate‐Free Polyurethane
Abstract This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using ( R )‐limonen...
Chelation‐Driven Electrolyte Design for Enhanced Interface and Electrochemical Window in Aqueous Aluminum Batteries
Abstract Aqueous aluminum‐ion batteries have garnered significant attention owing to the abundance of aluminum resources, high theoretical specific capacity, and...
Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions
Abstract Herein, we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth‐abundant, non‐toxic metal oxides are efficient mec...
Enhancing Acidic Oxygen Evolution Activity by Controlling Oxidation State of Iridium
Abstract Iridium oxides with high oxidation states have been reported to be effective in enhancing the acidic oxygen evolution reaction (OER) performance. Herein...
Solvent‐Mediated Charge Transfer Regulation of Inner Core Clusters in Hybrid Copper(I)‐Based Halides for High‐Efficiency X‐Ray Scintillation
Abstract Cu(I)‐based metal halides have gained significant interest as scintillators. However, their X‐ray luminescence efficiency is mainly determined by the co...
Enantioselective <i>de novo</i> Construction of Pyran‐2‐one‐fused Helicenoids via NHC Organocatalysis
Abstract Helicenoids have attracted considerable interest in diverse research areas owing to their unique structural and electronic characteristics. However, catalytic asymmetric syn...
A Cobotic, Digitally Controlled Schlenk‐line Unlocks Access to Elusive Lewis‐Base Stabilised Copper Bis(Disilylamides)
Abstract Silylamides are important ligands in coordination chemistry for their ability to stabilise low coordination numbers and provide soluble, and even volati...
Deciphering and Predicting Thermal and pH Stabilities of Triplex DNA Under Multifactorial Conditions
Abstract Triplex DNA, a critical noncanonical nucleic acid structure, plays essential roles in gene regulation, disease pathogenesis, and therapeutic targeting....
Two‐Step Crystal Dissolution: A Molecular Mechanism to Rationalize Empiric Models of Drug Release from API Formulations for Oral Administration
Abstract The kinetics of drug release from molecular crystals is commonly described by the Nernst‐Brunner model created in 1904 – and since then, numerous empiri...
Collision‐Induced Fragmentation of Oligosaccharides: Mechanistic Insights for Mass Spectrometry‐Based Glycomics
Abstract Structural alterations in oligosaccharides are often associated with disease, positioning clinical glycomics as an emerging tool for diagnostics. This is most commonly achie...