Angewandte Chemie International Edition
Articles in this Issue
Strong Oxide‐Support Interaction Induced Thermal Stabilization of Pt Single Atoms for Durable Catalytic CO Oxidation
Abstract Supported metal nanoparticle catalysts often suffer from sintering‐induced size‐dependent deactivation, limiting their high‐temperature applications. Al...
Metallaphotoredox‐Catalyzed Cross‐Electrophile Couplings of Aryl Chlorides and Alkyl Halides: Harnessing the σ‐Donor/π‐Acceptor Synergy of a 2‐(1 <i>H</i> ‐Imidazol‐2‐yl) pyridine Ligand
Abstract Cross‐electrophile coupling (XEC) reactions that forge C(sp 2 )─C(sp 3 )...
3D Covalent Arsenic Polyoxomolybdate‐Organic Polymer with Ultrahigh Photocatalytic Oxidative Ability for Aromatic C─H Activation
Abstract The photocatalytic activation of inert aromatic C─H bonds under mild conditions remains a major challenge due to the inherent stability of sp...
Formal Cyclopropylation of Imines with Cyclopropanols: Stereocontrolled Access to Conformationally Constrained γ‐Amino Alcohols
Abstract γ‐Amino alcohols are essential motifs in bioactive compounds and chiral catalysts, yet the synthesis of their conformationally constrained variants rema...
Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC‐MS
Abstract Neuropeptides are key neuromodulators in the central nervous system that shape sensory processing, yet their extracellular dynamics in the somatosensory...
Electrochemical Deoxygenative Silylation of Alcohols
Abstract Alcohols are highly common organic compounds but remain scarce as alkyl donors in synthetic procedures. Here, we describe an electrochemical procedure for their deoxygenativ...
Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions
Abstract Bridged nucleic acids (BNAs) are nucleoside analogues (NAs) in which the 2′‐alcohol is linked to the C4′‐position on ribose. In oligonucleotide therapeutics (ONTs), BNAs can...
Inside Front Cover: Reversing Pt/C Degradation Via Ni(OH) <sub>2</sub> ‐Wrapping Induced Spreading of Electric Field for Alkaline Hydrogen Evolution Reaction (Angew. Chem. Int. Ed. 39/2025)
Surface Reforming of Hard Carbon During Battery Rest for Enhanced Sodium Storage
Abstract The surface characteristics of hard carbon markedly affect its electrochemical performance. Here, a distinct surface modification of hard carbon (HC), w...
Biocatalytic Olefin Difunctionalization for Synthesis of Chiral 2‐Azidoamines Using Nonheme Iron Enzymes
Abstract Alkene difunctionalization represents an important category of reactions in organic synthesis, with a diverse array of transformations developed over th...
Unveiling an Alternative Mechanism for Lewis Basic Selenium as a C─H Hydrogen Bond Catalyst and Its Application in the Halogenation of Arenes
Abstract Electrophilic halogenation is a fundamentally useful transformation, and Lewis basic selenium catalysts together with N...
Selective Cascade Metathesis Polymerization of Dicycloalkenes and Their Chemical Recycling
Abstract Cascade metathesis polymerization (CMP) offers a powerful route to complex yet precise polymer microstructures. However, achieving both high cascade sel...
Lewis Acidity‐Governed Ion Exchange and Record Birefringence in A′[Ag <sub>3</sub> (PO <sub>3</sub> F) <sub>2</sub> ]
Abstract Four monofluorophosphates, A′[Ag 3 (PO 3 F) 2...
Lithium‐Bond‐Based Deep Eutectic Electrolyte Solutions for High‐Temperature Lithium Metal Batteries
Abstract Achieving long‐term cycling stability in high‐temperature lithium metal batteries (LMBs) demands both efficient ion transport and stable electrode inter...
Methylthiohexa‐1,3‐Diene: Anionic Polymerization of a Diene with Thioether Moiety Enables Post‐Polymerization Modification and Antimicrobial Materials
Abstract Anionic polymerization of 1,3‐dienes is a highly established approach for the synthesis of synthetic rubber and plays a key role for thermoplastic elast...
Transforming CO Poisoning into a Critical Step for Electrocatalytic C─N Coupling to Urea in a Carbon‐Dot‐Dominated Nanoreactor
Abstract Modern catalysis science has traditionally viewed carbon monoxide (CO) poisoning negatively due to its detrimental effects, such as the deactivation of...
Critical Role of Potential‐Driven Charge Effects in Hard Carbon Anodes for Sodium Storage
Abstract Sodium (Na) storage in hard carbon (HC) is a fundamental electrochemical process for sodium‐ion batteries, where adsorption energy critically influences charge/discharge rat...
Combined Inductive and Dispersion Effects Enhance Bioorthogonal Reactivity of Tetrazines Toward Isonitriles
Abstract Inverse‐electron demand cycloaddition reactions of tetrazines are widely used in bioorthogonal chemistry, but the opposing effects of substituents on reactivity and stabilit...
Molecular Insights into the Formation and Functionalization of Carbon Nanodots: From Precursor Intermediates to Surface Chemistry Quantification
Abstract Understanding the mechanistic pathways underlying carbon nanodot (CND) formation is essential for the rational design of synthesis strategies and the de...
Skeletal Remodeling of Pyridines Through Nitrogen Atom Transposition
Abstract Heterocyclic replacements are crucial tools in medicinal chemistry, enhancing the physicochemical properties of lead compounds. Pyridine, a core structural motif in numerous...
Triple‐Anion Coordination Design for Tuning Li <sup>+</sup> Transport Energy Barrier and Promoting the Performance of Li‐Ion Battery
Abstract The complex phase transitions of lithiated phosphorus (P) species‐derived interfacial side reactions can be substantially mitigated through a triple‐ani...
Evolution of Co <i> <sub>x</sub> </i> Ni <i> <sub>y</sub> </i> Alloy Electronic Structure Buffered by Carbon Nanolayer to Tune Selective Generation of Reactive Oxygen Species
Abstract Generation of non‐radical reactive oxygen species (ROS) via peroxymonosulfate (PMS) activation is desired to drive selective Fenton‐like reactions and s...
C <sub>60</sub> Fullerene as the Active Site for CO <sub>2</sub> Electroreduction
Abstract Fullerene (C 60 ) was considered as a catalyst promoter in various electrochemical reactions, yet its catalytic...
Programmable DNA Nanocages Enable Adaptive Spatiotemporal Organization of Biomimetic Organelle Networks
Abstract Synthetic organelles have emerged to simulate the multicompartmental organization and communication within cells. However, current synthetic organelles (e.g., lipid vesicles...
Ultrathin Aromatic Polyamide Membranes with Tunable Microporosity for Molecular Sieving
Abstract Advanced membrane technology for the separation and purification of active pharmaceutical ingredients (APIs) requires improvement in both membrane mater...