Angewandte Chemie International Edition
Articles in this Issue
Asymmetric Catalytic 1,2‐Azaarene Migration to α‐Azaaryl‐α‐Hydroxy Esters Enabled by a Tailored Ligand
AbstractDespite their prevalence in bioactive molecules, the stereoselective construction of α‐azaaryl‐α‐hydroxycarboxylates remains a formidable challenge. Notably, although the benzilic ester rearra...
The Importance of Si─ONa─Al Moieties in Fe/ZSM‐5 Zeolite Catalysts for Selective Oxidation of Methane to Acetic Acid
AbstractSelective oxidation of methane to acetic acid with high activity and selectivity remains a significant challenge. Brønsted acid sites (Si─OH─Al) are well‐known for their crucial role in facili...
Charge‐Rearrangement Averaged Dye Design for Precise, Real‐Time, and Portable Monitoring of Complex Solvent Environments
AbstractAlthough solvatochromic materials provide visual function to differentiate solvents, they fail to precisely monitor complex solvent environments where solvent composition varies dynamically, b...
Fe‐Triazolate Metal–Organic Frameworks as Water Oxidation Catalysts with Dual Photoanode Functionality
AbstractArtificial photosynthesis is an emerging technology that achieves renewable fuels, such as hydrogen, from sunlight. Its realization depends on finding highly active and stable catalysts of wat...
Dual‐Stimulus Programmed Multiphase Separation and Organization in Coacervate Droplets
AbstractStimuli‐responsive (multiphase) coacervates deserve significant attention as cell‐like entities that can adapt to their environment and undergo morphological reconfiguration. In this study, a...
Indeno[2,1‐<i>c</i>]fluorene Quasi[8]circulenes Through Intramolecular Cyclization
AbstractThe study of polycyclic aromatic hydrocarbons has become a cornerstone of chemical sciences, providing crucial guidance for advancing a wide range of fields. Within this context, quasi[8]circu...
Bioorthogonal In Situ Formation of AIE Luminogens for Imaging Disease Progression via Sigmoidal Signal Amplification
AbstractAggregation‐induced emission (AIE) luminogens are promising tools for biological imaging, yet their utility is often limited by nonspecific aggregation and elevated background fluorescence. He...
Green Fluorescent Protein SELEX: Immobilization Chemistry and His‐Tag Epitope Bias
Abstract Despite numerous DNA aptamers for proteins having been reported, a model system allowing the use of cost‐effective proteins, unmodified DNA, and conveni...
Accelerated Porosity Screening Using a Multichannel Colorimetric Array
AbstractPorous materials are important for many technologies, but the measurement of porosity by gas adsorption isotherms is slow, taking around one day per sample using a single‐port gas sorption ana...
A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer
AbstractPeptide‐based biosensors are widely used for in vitro detection of protease activity but often suffer from the limited sensitivity, poor accuracy, and incompatibility with point‐of‐care testin...
Paired Pulse Electrocatalytic Conversion of Phenol for Co‐Production of Cyclohexanol and <i>Para</i>‐Benzoquinone
AbstractElectrochemical upcycling of organic pollutants in wastewater into value‐added chemicals presents a dual solution for water treatment and sustainable synthesis, yet achieving high Faradaic and...
Nickelaelectro‐Catalyzed C─H Activation to <i>β</i>‐Arylated Pyrroles <i>via</i> Multiple Dehydrogenation
AbstractNickel electrocatalysis has emerged as a powerful strategy for sustainable C─H activation, offering an environmentally benign alternative to traditional methods based on stoichiometric oxidant...
Preparation of Degradable Polymers Containing Tunable Ratios of Dithioacetals and Disulfides via Mixed Mode Polymerization
AbstractDegradable polymers hold promise for their recyclability and their potential to facilitate the transition toward a circular economy of plastics. As such, a consecutive di‐SN2 reaction between...
Unlocking the Full Potential of SERS: Merging Direct and Indirect Approaches for Enhanced Analysis of Multiplex Plasticizer Analogs in Matrices
AbstractRapid and accurate identification of harmful plasticizer analogs in their native matrix is crucial for contaminant monitoring across industries. Surface‐enhanced Raman scattering (SERS) shows...
RETRACTION: Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas
RETRACTION: E. Santiago‐Rivera and T. Scheibel, “Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas,” Angewandte Chemie International Edition 64, no. 25 (2025): e202502068, htt...
Single Ag Atoms Induce Ag‐N/O Bonds on WO<sub>3</sub> for Ultrastable Acid Ammonia Synthesis
AbstractAmmonia from nitrate‐containing wastewater demands the catalysts with high activity, stability, and selectivity toward acidic electrochemical nitrate reduction owing to the corrosion effect of...
Cage Engineering in Anion‐Pillared MOFs for Benchmark One‐Step C<sub>2</sub>H<sub>4</sub> Purification from Ternary C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub>/C<sub>2</sub>H<sub>4</sub> Mixtures
AbstractOne‐step purification of ethylene (C2H4) from the ternary mixtures of acetylene/carbon dioxide/ethylene (C2H2/CO2/C2H4) is a critical industrial challenge due to their similar physical and che...
Engineering Anion‐Diluent Matrix for Ion‐Decoupled Localized High‐Concentration Electrolytes toward Highly Stable Aqueous Zinc Ion Batteries
AbstractAqueous zinc‐ion batteries suffer from electrolyte‐induced degradation despite their inherent safety advantages. While localized high‐concentration electrolytes (LHCEs) mitigate interfacial in...
Promiscuity in Molecular Mimics of the Cysteine Dioxygenase: Effects of Selenium in the Substrate and Cobalt as the Central Metal Ion
AbstractCysteine dioxygenase (CDO) catalyzes the conversion of cysteine with dioxygen to yield cysteine sulfinic acid, which lies at the branching point of cysteine catabolism. Despite many years of r...
David B. Konrad
Excitation‐Wavelength‐Dependent Emission of Congruently Melting Iodocuprate Hybrid Materials
AbstractIn the context of the emergence of metal halide perovskites for optoelectronic materials, the lead‐free and earth‐abundant copper(I)‐based halide hybrids are of high interest. Here, we report...
Advancing Organic Chemistry Using High‐Throughput Experimentation
AbstractHigh‐throughput experimentation (HTE), the miniaturization and parallelization of reactions, is a valuable tool for accelerating diverse compound library generation, optimizing reaction condit...
Expanding the Synthetic Playbook with a Biochemical Twist: The 58<sup>th</sup> Bürgenstock Conference
Behavior Regulation of *CO over Self‐Evolution Tandem Catalysts Under Tuned Interfacial Electric Field Boosts CO<sub>2</sub> Electroreduction
AbstractTandem or self‐evolution Cu‐based catalysts effectively regulate *CO to promote the conversion of CO2 electroreduction to multicarbon (C2+) products. DFT calculations reveal that the adsorptio...
Tailoring Co Coordination Mode in COF Nanosheets for Efficient Solar‐Driven Reduction of Non‐Neat CO<sub>2</sub> into Syngas
AbstractPhotocatalytic conversion of CO2 into syngas is a promising approach to solving energy and environmental challenges. However, the current studies are mainly conducted by using neat CO2 where C...