Angewandte Chemie International Edition

Selective Chemical Manipulation of Mannosyl‐ and Galactosyl‐Queuosine in tRNAs of Living Cells

Abstract Queuosine is a hypermodified nucleoside found in the anticodon loop of tRNAs decoding the amino acids His, Asn, Tyr, and Asp. In tRNA...

Rational Design of an Organotellurium Chalcogen Bonding Catalyst for Azetidine Activation

Abstract The application of chalcogen bonding catalysis has been largely confined to benchmark reactions due to the limited structural diversity and activating ability of the catalys...

Jess M. Clough

Machine Learning Guided Assembly of a Nested Gd ₂₀ @Gd ₃₂ @Ni ₃₆ Cluster via Urea Controlled Carbonate Release

Abstract Lanthanide‐based polyhedral clusters are of great interest due to their unique geometries and functional properties, but their controlled synthesis rema...

Conformation‐Adaptive Transformations of Flexible Frameworks: From Controlled Stimuli‐Responsiveness to Regulated Responsive Behaviors

Abstract Synthesizing enzyme‐like porous materials that can regulate responsiveness through conformations remains a challenge. Here, two flexible framework confo...

Electrochemical Conversion of Methane to C ₂₊ Hydrocarbons and Hydrogen

Abstract Catalytic methane (CH 4 ) upgrading to C 2+ products has attracted wides...

Orbital Rehybridization Enabling Abundant Pentagonal–Heptagonal Rings in Hard Carbon for Optimal Sodium‐Ion Batteries

Abstract Curvature structure modulation through the introduction of abundant non‐hexagonal (pentagonal and/or heptagonal) rings results in structural mutation an...

The Origin of the Feedstock Molecules for Life on the Hadean Earth

Abstract The origin of life in the Hadean eon required the formation of amino acids and nucleosides among the key molecules of life. It is assumed that highly un...

Rocking (and Shuttling) in a Nanosized Metallobox

Abstract Gaining insight into the dynamic behavior of supramolecular systems is essential for understanding selective guest encapsulation and for the rational de...

Are Grignard Reactions in Deep Eutectic Solvents Interface‐Driven?

Abstract Due to their high reactivity, organolithium and organomagnesium addition to ketones is usually performed under inert atmosphere at low temperature. Rece...

Cationic–Zwitterionic Polymer Electrolytes with Enhanced Ionic Conductivity and Lithium‐Ion Selectivity for Solid‐State Batteries

Abstract Polymer electrolytes are attractive for solid‐state lithium–metal batteries owing to their favorable interfacial compatibility and scalable processabili...

Ion‐Mediated Self‐Healing Strategy Enabling Efficient and Stable ETL‐Free Perovskite Solar Cells

Abstract Perovskite solar cells without electron transport layers (ETL‐free PSCs) have garnered increasing attention in recent years due to their simplified fabr...

Multicomponent Assembly of High‐Component Covalent Organic Cages

Abstract Multicomponent reactions (MCRs), a powerful strategy for generating desired products by employing more than two starting materials in one‐pot reactions, have been determined...

A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents

Abstract We describe a strategy for aminating pyridines and other azines via phosphonium salt intermediates. Precisely tuning the electronic properties of the ph...

Outside Front Cover: Multifunctional Electronic Textiles for the Simultaneous Detection and Uptake of Hydrogen Sulfide (Angew. Chem. Int. Ed. 42/2025)

High‐Fidelity Profiling of Multiple Nearby Mutations via Cooperative Recognition

Abstract Detection methods with single‐nucleotide specificity are essential tools for nucleic acid analysis in diverse clinical and biological settings. However, both hybridization‐b...

Gadolinium and Europium Doped Chiral Perovskite Films with Magnetic Circular Dichroism and Circularly Polarized Luminescence for Information Encryption Applications

Abstract All inorganic lead halide perovskite (CsPbX 3 ) has become a hot topic in chiral optics for its high quantum yie...

Full P ₄ to P ³⁻ Reduction with a Redox‐Active Metal Crown Complex

Abstract Traditional bulk syntheses of phosphorus compounds start with P 4 to PCl 3...