Angewandte Chemie International Edition
Articles in this Issue
Selective Atomic Incorporation: Synergistically Tailoring Adsorbate Evolution and Lattice Oxygen Pathways for Enhanced Water Oxidation
Abstract Oxygen evolution reaction (OER) remains a key bottleneck in water splitting, hindered by sluggish kinetics and complex catalytic mechanisms. Here, we sy...
Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes
Abstract Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation o...
Enzymatic Flow Electrolyzer for CO <sub>2</sub> and Waste Comproportionation to Formate and Its Use in Photocatalytic Alkene Hydrocarboxylation
Abstract Paired electrolysis enables the simultaneous coupling of CO 2 reduction with anodic waste upcycling to form valu...
Reversing Lanmodulin's Metal‐Binding Sequence in Short Peptides Surprisingly Increases the Lanthanide Affinity
Abstract Rare earth elements (REEs) are essential for a clean energy future, high tech, and medicine. For these applications the chemically similar elements need...
Late‐Stage Oxidation of C( <i> sp <sup>3</sup> </i> )─H Bonds with High Efficiency and Alkyl Group Dihydroxylation of Complex Molecules
Abstract The late‐stage oxidation of C( sp 3 )─H bonds...
Frontispiece: Unlocking DAST‐Type Reagents for Modular Synthesis of Sulfur‐Containing Motifs
A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading
Abstract Extracellular vesicle (EV) surface proteins serve as the fundamental signaling mediators, determining the communication function of EVs. The selective and in‐depth explorati...
Active Transport of Macrocycles into Micelles Using Molecular Pumps
Abstract During the past decade, researchers have designed and synthesised a variety of artificial molecular pumps capable of the active transport of macrocycles (rings) from free so...
Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
Abstract Installing functional groups at specific sites in existing RNA molecules remains a challenge for modification, labeling, and therapeutic strategies. Her...
Amine‐Ligated Boryl Radicals Enables Direct C─F Borylation and Cross‐Couplings of Polyfluoroarenes
Abstract Polyfluoroarenes are privileged scaffolds in pharmaceutical and materials science, yet their synthesis remains challenging. Aromatic borylation offers a modular entry point...
Structural Tweaking of Zwitterionic Metallosupramolecular Assemblies for Intense NIR Emission and High Charge Carrier Mobility
Abstract Metal organic materials (MOMs) with intense NIR emission and charge transport are essential for biomedical and bioelectronic applications, particularly...
Toward Iron‐Catalyzed Alkene Metathesis: Mapping the Reactivity and Deactivation Pathways of an Iron Metallacyclobutane
Abstract Iron‐catalyzed alkene metathesis holds great promise as a sustainable alternative to its precious metal congeners, yet its development has been hindered...
Frontispiece: Transient Induction of Chirality from an Activated Carboxylic Acid to a Zinc Complex
Development and Clinical Evaluation of a Multiplexed Health Surveillance Panel Using Ultra High‐Throughput PRM‐MS in an Inflammatory Bowel Disease Cohort
Abstract Despite advances in clinical proteomics, translating protein biomarker discoveries into clinical use remains challenging due to the technical complexity of the validation pr...
Hybridized Multi‐Spiral Donor Engineering for High‐Efficiency Narrowband Thermally Activated Delayed Fluorescence Emitters
Abstract The pursuit of narrowband multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters with both high efficiency and color purity remains...
Unlocking DAST‐Type Reagents for Modular Synthesis of Sulfur‐Containing Motifs
Abstract Multi‐heteroatom‐substituted sulfur centers are increasingly significant in drug discovery, yet their modular synthesis remains challenging. Current str...
Bicyclic Isosteres of Pyridine/Piperidine: From Synthesis to Applications
Abstract 2‐Azabicyclo[2.2.2]octanes have been designed, synthesized, and validated biologically as isosteres of piperidine/pyridine. The key reaction step was th...
Site‐Selective α─C─H Functionalization of Saturated Heterocycles via Copper‐Photoredox Catalysis
Abstract Site‐selective α─C─H functionalization of saturated heterocycles is of particular importance in synthetic and medicinal chemistry, but the intrinsic che...
Hydrophobic Polymer Zwitterions: Impacts of Silylsilane Substitution on Solution and Interfacial Properties
Abstract A new class of zwitterionic polymer amphiphiles was prepared by synthesis and polymerization of novel silyl‐substituted sulfobetaine (SB) methacrylate monomers. These silyl‐...
N‐Heterocyclic Carbenes on a III‐V Semiconductor: From Chain Formation to Ordered Monolayers
Abstract N‐Heterocyclic carbenes (NHCs) are established ligands for various surfaces, known for their strong binding, ability to form self‐assembled monolayers, and modular structure...
Enantioconvergent Borylation of α‐Benzoyl Alkyl Bromides by Zinc Catalysis
Abstract The direct synthesis of chiral compounds from racemic alkyl halides is highly valued in organic synthesis. In this study, we present the first zinc‐catalyzed enantioconverge...
Bifunctional Probes Reveal the Rules of Intracellular Ether Lipid Transport
Abstract Ether glycerophospholipids bear a long chain alcohol attached via an alkyl or vinyl ether bond at the sn1 positi...
Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides
Abstract Antisense oligonucleotides are promising therapeutic agents for a range of diseases, having found special clinical success for splice‐switching genetic conditions such as sp...
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in <i>Inocybe</i> and <i>Psilocybe</i> Mushrooms
Abstract Psilocybin (4‐phosphoryloxy‐ N , N ‐dimethyltryptamine,...
Air‐Stable Allyl Radicals and Heterocoupled Dimer: Synthesis, Characterization, and Near‐Infrared Emissions
Abstract Air‐stable luminescent monoradical remains rare. Herein, we report novel stable allyl radicals ( ARS ) achieved...