Angewandte Chemie International Edition
Articles in this Issue
Regio‐, Stereo‐, and Enantioselective Copper‐Catalyzed Allylation of Sulfinylamines with Allenes
Abstract Sulfinamides, pivotal scaffolds in modern organic synthesis, have undergone a continuous evolution of synthetic methodologies over the past century, yet the precise construc...
Aqueous Zinc‐Ion Pouch Cells: From Failure Mechanisms to Practical Solutions
Abstract Aqueous zinc‐ion batteries (AZIBs) have been regarded as promising candidates for stationary energy storage owing to their low cost, inherent safety, and high volumetric ene...
Direct Boron‐10 Access: Nickel‐Catalyzed Reductive C(sp <sup>2</sup> )─ <sup>10</sup> B Coupling Utilizing <sup>10</sup> BF <sub>3</sub>
Abstract The boron‐10 isotope ( 10 B) is critical for boron neutron capture therapy (BNCT); however, the direct use of in...
Photochemical Di‐π‐Methane Rearrangement Reactions
Abstract Photochemical di‐π‐methane (DPM) rearrangement, a classic transformation pioneered by Zimmerman, elegantly converts 1,4‐dienes and related systems into...
Energy‐Efficient Dual Formate Electrosynthesis via Coupled Formaldehyde Oxidation and CO <sub>2</sub> Reduction at Ultra‐Low Cell Voltage
Abstract Electrochemical formate (HCOO − ) production via CO 2 reduction reaction...
Frontispiece: [3]CycloBODIPY: A Highly Strained Cyclic BODIPY Trimer with Effective Macrocyclic Conjugation
Asymmetric Acetylene Activation Enables Enhanced Electrochemical Ethylene Formation Kinetics
Abstract Copper (Cu)‐based catalysts with weak ethylene (C 2 H 4 ) adsorption exh...
Catalytic Enantioselective Synthesis of Axially Chiral Tetraarylethenes
Abstract Chiral TAEs hold great promise for the development of optically active materials. However, current strategies for constructing such structures are largely limited to introdu...
Si−H Activation via Dynamic Permutational Isomerism: A Ligand‐Directed Route to Dehydrogenative Coupling
Abstract Dehydrogenative coupling (DHC) of hydridosilanes with silanols under metal‐free conditions provides a sustainable route to Si─O bond formation. Yet, the...
Boosting the Ionic Conductivity of Non‐Aqueous Proton Electrolyte for Hybrid Capacitors
Abstract Proton batteries have emerged as promising alternatives for energy storage owing to their rapid H⁺ transport kinetics and environmental sustainability....
Inside Front Cover: Proton‐Resistant <i>N</i> ‐Heterocycle‐Linked TEMPO Catholytes for Long‐Lasting Neutral Aqueous Organic Redox Flow Batteries (Angew. Chem. Int. Ed. 47/2025)
A Robust Heterometallic Pt <sub>2</sub> Pd <sub>2</sub> L <sub>8</sub> Double Cage Catenane
Abstract The combination of different metal ions in supramolecular structures can lead to the emergence of new features, such as enhanced stability, reduced symm...
Homologative 1,3‐Functionalization of Alkenes via an Iodomethyl Thianthrenium Reagent
Abstract Despite tremendous progress in alkene 1,2‐difunctionalization, analogous methods to generate 1,3‐patterns from alkenes remain limited. Recently, Silvi a...
Frontispiece: Energy‐Efficient Dual Formate Electrosynthesis via Coupled Formaldehyde Oxidation and CO <sub>2</sub> Reduction at Ultra‐Low Cell Voltage
Cu Evolution over Bimetallic Cu‐Y/Beta Zeolite Under H <sub>2</sub> and Ethanol Atmospheres: Unveiling the Role of Diatomic Metal–Metal Interactions
Abstract Understanding the dynamic evolution of Cu species under varying environmental conditions is critical for addressing challenges related to the activity a...
Ligand Effects in Regio‐ and Enantioselective Cobalt‐Catalyzed Intramolecular [4+2]‐ and [2+2]‐Cycloaddition Reactions of Unactivated 1,3‐Diene‐8‐ynes and 1,3‐Diene‐8‐enes
Abstract Intramolecular Diels–Alder reactions have been extensively used for the syntheses of biologically active compounds including natural products. We have i...
Hybrid of Indolizine and Merocyanine—A New Class of Organelle‐Specific Dyes
Abstract Unlocking the potential of electron‐rich 2‐hydroxyindolizines led to the discovery of a new class of dyes—indolizine‐merocyanines (IndMer) and indolizine‐cyanines. Tandem Fr...
Simultaneous Measurement of RNA Synthesis and Degradation Rates in Single Cells Unveils the Regulatory Mechanisms of Temporal RNA Dynamics
Abstract The temporal dynamics of coordinated RNA transcription and degradation are heterogeneous among different cell types or states. However, current transcriptomic approaches are...
Programmable Ultralong Phosphorescent Ionogels for Intelligent Monitoring
Abstract Pure organic flexible RTP materials show broad application prospects in fields such as electronic sensing and high‐resolution displays. IGs offer advant...
Defects Induced in Situ Reconstruction of CdS with Oxygen‐Tolerance Up to 23% in the Photocatalytic CO <sub>2</sub> Reduction
Abstract Direct driving the photocatalytic reduction of CO 2 from air or flue gas to produce value‐added chemicals and fu...
Near‐Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy
Abstract With this research we developed a cyclization strategy that effectively converts radiative transitions (RTs) to non‐radiative transitions (NRTs) during...
Quantifying the Biodegradation of Water‐Soluble Polymer Mixtures with Diffusion NMR Spectroscopy
Abstract Polymers in liquid formulations result in 36 million tons of waste each year. It is estimated that 13% of these polymers directly enter, and accumulate in, natural environme...
Single‐Molecule DNA Tweezers Enable Programmable Control of Enzyme Activity via Arbitrary Molecular Cues
Abstract Engineering allosteric control sites into enzymes typically requires extensive protein modification. Here, we introduce single‐molecule DNA tweezers (SMDTs), which enable pr...
Formation of Interconnected Nanofiber Sheets by Chemical Vapor Polymerization at the Free Surface of Liquid Crystalline Films
Abstract We report that chemical vapor polymerization (CVP) of aminomethyl[2.2]paracyclophane into nematic liquid crystal (LC) films (thicknesses of 18 µm) yields quasi‐two‐dimension...
Cleavable Antibody‐Conjugated Aβ Specific Immune Exosome for Combination Alzheimer's Disease Immunotherapy
Abstract Recent progress in antibody‐based immunotherapies for Alzheimer's disease (AD) brings a sense of cautious optimism after years of setbacks. However, these approaches remain...