Angewandte Chemie International Edition
Articles in this Issue
Atomic Coordination Engineering of Sub‐Nanometer Cu Clusters for Selective CO <sub>2</sub> Electroreduction to Multi‐Carbon Alcohols
Abstract Electrochemical conversion of CO 2 to multi‐carbon (C 2+ ) alcohols rema...
Covalent Organic Framework Membranes with Asymmetric Wettability for Efficient Photocatalytic H <sub>2</sub> O <sub>2</sub> Synthesis
Abstract Photocatalytic H 2 O 2 synthesis from air and water is a sustainable rou...
Discovery and Total Synthesis of Crossiguanipyrazines with Potent Activity Against <i>Mycobacterium tuberculosis</i>
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis , remains one of the most devastating infectious disease...
Flipping of a Non‐productive Substrate Binding Conformation Facilitates Hydroxynitrile Lyase Catalyzed Hydrocyanation
Abstract Understanding enzyme–substrate conformational transformations is crucial to the design and engineering of biocatalysts. However, the mechanisms by which...
Inside Back Cover: Flipping of a Nonproductive Substrate Binding Conformation Facilitates Hydroxynitrile Lyase Catalyzed Hydrocyanation (Angew. Chem. Int. Ed. 52/2025)
Emergent Chemical Reactivity and Complexity of RNA Condensates
Abstract The RNA world hypothesis posits the existence of life‐like assemblies that consisted mostly of RNA. However, questions remain regarding the emergence of RNA catalysis, stabi...
Directing the Electrochemical C─N Coupling Toward Efficient Amide Synthesis via Ammonia Activation‐Mediated Pathway
Abstract Electrochemically oxidative C─N coupling using alcohol and ammonia as feedstocks offers a sustainable alternative for the chemosynthesis of amide organo...
Integrative Ni <sub>1</sub> –P <i> <sub>x</sub> </i> Catalytic Pairs for Low‐Concentration CO <sub>2</sub> Electroreduction
Abstract The electrochemical CO 2 reduction reaction (CO 2 RR) powered by renewab...
Photochromic Cs <sub>2</sub> Pb(NO <sub>3</sub> ) <sub>2</sub> Br <sub>2</sub> Perovskite Nanosheets as a Novel Anti‐Counterfeiting Material
Abstract Although the photoinduced segregation phenomenon of mixed halide perovskites has application potential in the fields of anti‐counterfeiting and informat...
Selective Electrocatalytic CO <sub>2</sub> Reduction to Methanol: A Roadmap toward Practical Implementation
Abstract Electrocatalytic CO 2 reduction to methanol (MeOH) unites two urgent global needs, carbon recycling and renewabl...
Near‐Unity Intersystem Crossing Efficiency and Bright Polymer Phosphorescence Enabled by Charge‐Transfer Diarylketones
Abstract Bonding aromatic ring to carbonyl group is recognized as crucial for promoting intersystem crossing (ISC) owing to allowed 1...
Iron/NHC‐Catalyzed Regio‐ and Stereoselective 1,6‐Additions of Aliphatic Grignard Reagents to α,β,γ,δ‐Unsaturated Carbonyl Compounds: Asymmetric Variants with Chiral NHCs
Abstract Although conjugate addition to an α,β‐unsaturated carbonyl compound is a well‐established method in synthetic organic chemistry, controlling regioselect...
Harnessing Deaminated DNA to Modulate mRNA Translation for Controlled and Sequential Protein Expression
Abstract Messenger RNA (mRNA) offers transformative potential in vaccines and therapeutics for a range of intractable diseases. While considerable efforts have focused on enhancing p...
Intra‐Configurational Spin‐Flip <i>d</i> → <i>d</i> Transition of Mo (III) Doped Perovskite for Ultra‐Narrow Near Infrared‐II Emission in Ambient Conditions
Abstract Sharp near‐infrared‐II (NIR‐II) emissions are typically achieved through electronic transitions of rare‐earth ions, while transitions in transition me...
Optical Switching of Catalytic Pathways for Hydrogen Generation via Light‐Handedness Control on Chiral Nanostructures
Abstract Precise optical control over catalytic pathways remains a major challenge in solar‐driven hydrogen production. Here, we report a reversible light‐handed...
Correction to “Photo‐Switchable Peroxidase/Catalase‐Like Activity of Carbon Quantum Dots”
Topological Duality: Constructing High‐Nuclearity Metal Clusters with Unleashed Active Sites for Efficient and Durable CO <sub>2</sub> Electroreduction
Abstract Precise control of active sites with atomic resolution in metal nanoclusters (MNCs) presents a promising avenue for catalyst engineering towards CO...
Integrating the Substituent Effect into the Wade–Mingos Rules for Dicarboranes
Abstract This work revisits the Wade–Mingos (W–M) rules in carborane chemistry by showing that substituent effects, rather than skeletal electron pairs alone, de...
Outside Front Cover: Shape‐Matched Nonpolar Pore Surfaces Enhance Alkane Recognition Toward Natural Gas Upgrading (Angew. Chem. Int. Ed. 52/2025)
Aminative Suzuki–Miyaura Coupling: Tackling Alkyl Nucleophiles and Addressing the Viability of the Electrophile‐First Mechanism
Abstract Insertive cross‐coupling reactions provide the option of repurposing widely available coupling partners for the formation of new linkages. By confrontin...
Catalytic Asymmetric Aza‐[2+2] Cyclization Reaction of Simple Ketoimine
Abstract Herein, we report the first catalytic enantioselective aza‐[2+2] cyclization of simple ketoimines, thereby addressing a persistent challenge in four‐membered aza‐ring constr...
Pollutants Transformation During the Regeneration Process of Fluid Catalytic Cracking Catalysts
Abstract Fluid catalytic cracking (FCC) is the major process for heavy oil conversion in current refineries and is explored for the intake of renewable feedstock...
De Novo Design of High‐Affinity Miniprotein Binders Targeting <i>Francisella Tularensis</i> Virulence Factor
Abstract Francisella tularensis poses considerable public health risk due to its high infectivity and potential for bioterrorism. Francisella...
Thermally Activated Stereoinversion in Benzotrithiophene‐Based Supramolecular Polymers with Water as the Effector
Abstract We report the synthesis of the chiral benzotrithiophene (BTT) derivative 1 , which self‐assembles into helical s...
Selective Reductive Amination of Carbonyls to Primary Amines Under Ambient Conditions Over Rh/MFM‐300(Cr)
Abstract The synthesis of organic amines via reductive amination of biomass‐derived carbonyl compounds is an important target for sustainable chemical industries...