Angewandte Chemie International Edition
Articles in this Issue
Engineering Intralayer Anisotropy in Covalent Organic Frameworks
Abstract Precise control of intralayer anisotropy in two‐dimensional covalent organic frameworks (COFs) remains a significant challenge in materials design. We address this through a...
Analyte‐Targeted Plasmonic Hotspots on Superlattice Mirror Enable Ultra‐Broad‐Range SERS Sensing of Acetylcholinesterase
Abstract Surface‐enhanced Raman spectroscopy (SERS) enables molecular fingerprinting, but its widespread application is limited by poor detection sensitivity and...
Accessing Molecular Complexity from Methane and Other Gaseous Alkanes via Photocatalytic Cascade Cyclization
Abstract The direct transformation of simple and abundant feedstocks into structurally complex molecules remains a central challenge in modern organic synthesis....
Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet?
Abstract Mass spectrometry (MS)‐based top–down proteomics (TDP) has emerged as a powerful tool for characterizing proteoforms to advance both fundamental and translational research....
Deciphering <i> E <sub>g</sub> </i> Occupancy Descriptor in Oxygen Electrocatalysis
Abstract Single variable descriptors serve as pivotal tools for evaluating catalyst performance, elucidating reaction mechanisms and guiding catalyst design in e...
Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes
Abstract An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL‐derived ligand. Racemic THP sub...
Facilitating the Construction of Strong Metal‐Support Interaction via Accelerating the Hydrogen Catalysis
Abstract Strong metal‐support interaction (SMSI) critically regulates the catalytic performance of supported metal catalysts. Conventionally, a high‐temperature...
Through‐Space Charge Transfer Complexes Based on Terpyridine Bi‐Functionalization for Efficient Solar‐Driven H <sub>2</sub> O <sub>2</sub> Production
Abstract To achieve precise spatial control of donor–acceptor (D–A) stacking and optimize through‐space charge transfer (TSCT) for efficient photocatalysis, we d...
Versatile and Selective Biomolecule Pulldown with Combinatorial DNA‐Crosslinked Polymers
Abstract Current methods for sequence‐selective biomolecule isolation suffer from high cost, off‐target effects, and limited flexibility. Here, we introduce...
Structural Symmetry and Mixed‐anion Engineering in Halopnictides for Extraordinary Second‐Harmonic Generation
Abstract Achieving high nonlinear optical (NLO) coefficients in NLO materials remains a significant challenge. Herein, based on the [Cd 4...
Solvent‐Directed in Situ Stacking Modulation of 2D Covalent Organic Frameworks for Selective Separation of Xylene Isomers
Abstract The precise regularity of stacking modes in two‐dimensional covalent organic frameworks (2D COFs) remains insufficiently understood, and achieving precise control during syn...
The Zintl–Klemm Concept in the Amorphous State: A Case Study of Na–P Battery Anodes
Abstract The Zintl–Klemm concept has long been used to explain and predict the bonding, and thereby the structures, of crystalline solid‐state materials. We apply this concept to the...
Pd/Cu Single Atom Alloys for Selective Alcohol Dehydrogenation: From Single Crystalline to Nanostructured Model Catalysts
Abstract Heterogeneous catalysts based on Single Atom Alloys (SAA) play a significant role in numerous technical processes. The fundamental working principles of...
From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi‐Hydrogenation
Abstract We report here the upcycling of PET (polyethylene terephthalate) waste via semihydrogenation to make ethyl 4‐(hydroxymethyl)benzoate. The reaction is ca...
Reversible Na <sup>+</sup> /I <sup>−</sup> Dual‐Ion Chemistry by Electrolyte Engineering Enables High‐Rate and Long‐Lifespan Energy Storage Device
Abstract Aqueous battery energy storage systems have driven extensive attention owing to safety, low‐cost, and environmental friendliness. However, the dendrite...
Pulsed Electrolysis Promotes CO <sub>2</sub> Electroreduction to Multicarbon Products by Suppressing Electrolyte Flooding
Abstract Electrochemical CO 2 reduction (CO 2 RR) converts CO...
A Radical Cascade with Double Intramolecular Hydrogen Atom Transfer for the Generation of Bisfunctionalized Cyclopentanes from Linear Alkynes
Abstract Radical cascade reactions represent a powerful synthetic tool for the preparation of complex molecules from easily assembled starting materials. The inc...
Spin‐Polarization in Rigid/Soft Layered Oxide Catalyst Regulates Key Intermediates for Efficient CO <sub>2</sub> ‐to‐Formate Conversion
Abstract Precise control of metal oxidation states is pivotal in regulating the adsorption energetics of *OCHO intermediate during CO 2...
Aromatic Pentaamide Macrocycles as High‐Affinity Sulfate Binders and Efficient Transporters
Abstract The binding and transport of the highly hydrophilic sulfate ion pose a significant challenge. Receptors capable of both strong sulfate binding and effic...
Temperature‐Controlled Synthesis of Corannulene‐Based Multi‐Helicenes: Highly Integrated Curvature/Planarity for Enhanced CPL Brightness and Solid‐State Luminescence
Abstract Corannulene and hexabenzocoronene ( HBC ), as archetypal bowl‐shaped and planar nanographene, have attracted con...
Switchable Reactivities of Metalated Phosphasilenes Regulated by Reversible 1,2‐Metal Migration
Abstract Anionic reagents with silicon‐containing double bonds, M(R)Si═ER n (E = main group elements), have garnered sign...
Hexabenzocoronene–Benzimidazole Hybrid Architectures and Faraday Rotation of the First Hexabenzocoronene–Phthalocyanine
Abstract The synthesis and characterization of a first example of a Ni‐phthalocyanine (Pc) hybrid molecule carrying four hexa‐ peri‐...
Time‐Resolved In‐Cell Protein Interactions and Structural Dynamics via Rapid Buffer Online Exchange‐Ion Mobility‐Mass Spectrometry
Abstract Observing protein structural dynamics directly within the complex cellular milieu is crucial for understanding biology but is hampered by severe matrix interference in mass...
Reconfiguring Ionomers in Proton Exchange Membrane Fuel Cell Catalyst Layer to Promote Multi‐Species Transport and Durability
Abstract In proton exchange membrane fuel cells (PEMFCs), ionomers in the catalyst layer tend to align lamellar to the catalyst surface, impeding the formation of continuous ionic do...
Site‐Specific and Regioselective Modification of Human Epidermal Growth Factor Receptor 2 via Site‐Sculpted DNA Nanorefiners
Abstract The site‐specific modification of native proteins is essential for regulating their functions and behaviors in biological systems. Such modifications enable advanced studies...