Angewandte Chemie International Edition
Articles in this Issue
Resolving the Efficiency–Mechanical Trade‐off in Organic Solar Cells: 20.4% Enabled by Hydrogen‐Bonding Engineering
ABSTRACT Organic solar cells (OSCs) face a trade‐off between power conversion efficiency (PCE) and mechanical robustness: high toughness requires low‐crystallini...
Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides
ABSTRACT The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per‐ and polyfluorinated alkyl s...
Modulation of Local Hydrogen Bonding for Highly Efficient Bi‐MOFs Photocatalyzed Fixation of N <sub>2</sub> in Aqueous Solution
ABSTRACT For photocatalytic reduction of dinitrogen in aqueous solution, water plays an important role as not only a reactant to supply protons via the water oxi...
Proton‐Activated Artificial Channels for pH‐Selective Cancer Therapy
ABSTRACT Proton‐activated ion channels mediate ion transport in response to extracellular acidification, enabling cellular adaptation to acidic microenvironments...
Simultaneous Boost of SF <sub>6</sub> Adsorption Capacity and Kinetics Through Isoreticular Functionalization of Zinc(II)‐Pyrazolate Frameworks
ABSTRACT The capture of sulfur hexafluoride (SF 6 ), the most potent greenhouse gas, is of critical importance. Enhanceme...
Inert Complexes Unlock Ligand‐Accelerated Transition‐Metal Catalysis on Proteins
ABSTRACT Reactions that excel in small‐molecule settings typically require metal loadings far exceeding the number of protein reaction sites (often ≥10‐fold) onc...
Palladium‐Catalyzed Enantioselective Four‐Component Carbonylative Dicarbofunctionalization of Internal Alkenes With 1 Atm CO
ABSTRACT Transition metal‐catalyzed carbonylation employing CO as a C1 feedstock is fundamental for synthesizing carbonyl compounds in industrial/fine chemical synthesis. Despite the...
Spatial Molecular Engineering of Hole Semiconductors Enables Record Efficiency and Durability in Inverted Perovskite Solar Cells
ABSTRACT Conventional small‐molecule hole‐transporting materials (SM‐HTMs), although morphologically robust, typically suffer from limited hole mobility, interfacial energy misalignm...
Iizuchalasin A: A Marine Fungal Metabolite With a Cage‐Like Structure That Binds TarG to Inhibit Wall Teichoic Acid Biosynthesis by Multidrug‐Resistant <i>S. aureus</i>
ABSTRACT To address the ongoing Staphylococcus aureus drug resistance, we screened marine fungal extracts against a multi...
Split‐Deliver‐Click: Tumor‐Specific Protein Degradation via “AND” Logic‐Gated In‐Cell Bioorthogonal Clicking of PROTACs
ABSTRACT PROteolysis TArgeting Chimeras (PROTACs) represents a promising therapeutic modality with the potential to revolutionize targeted protein degradation. However, challenges su...
Programmable Anisotropic in Diazapyrene Cocrystals With Birefringence Exceeding 1.2
ABSTRACT Birefringent crystals underpin polarization control and angular phase matching in nonlinear optics and therefore, attract sustained interest. However, a...
Multidirectional Charge Separation in Self‐Assembled Aggregates of Perylenebisimide‐Porphyrin Bola‐Supra‐Amphiphiles
Abstract We report on the synthesis of a hydrogen‐bond mediated bola‐type supra‐amphiphile and assembly thereof in water. The assembly is based on amphiphilic porphyrins and hydropho...
Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight
ABSTRACT Rhomboid proteases, a class of intramembrane proteases characterized by a Ser‐His catalytic dyad, have recently emerged as promising therapeutic targets...
Rapid RASER MRI
Abstract Conventional Magnetic Resonance Imaging (MRI) relies on high‐power Radio‐Frequency (RF) pulses to excite nuclear spins and in turn generate NMR signals....
Hidden Diradical: Conformational Switch for Solvatochromic NIR Emission With Unity Quantum Yield in Thiele's Hydrocarbon
ABSTRACT We present that halogen‐substituted and air‐stable Thiele‐type diradicaloids with folded ( 1 ) and planar (...
An Iridium‐Catalyzed Conia‐ene Reaction for the Diastereo‐ and Enantioselective Synthesis of Complex Ring Systems
Abstract Iridium‐catalyzed Conia‐ene reactions of α‐amino amides are described. These units undergo 6‐ or 7‐ exo cyclizat...
Double‐Cyclized Dipeptides for Hierarchical Self‐Assembly Into Crystalline Macroscopic Superhelices
ABSTRACT Cyclic peptides have attracted significant attentiondue to their persistent structures and particular biological effects, which are also key building blocks for creating fun...
Zinc‐Complex Orchestrating Pyroptosis for Hypoxia‐Tolerant Photoimmunotherapy
ABSTRACT Photon‐driven pyroptosis represents an advanced and promising modality in anti‐tumor immunotherapy, offering new avenue in combating cancer recurrence a...
PCA‐Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation
ABSTRACT Protein engineering is a practical approach to providing enzymes with an “abiotic” catalytic activity. However, it remains difficult to explore the full diversity of natural...
Circularly Polarized Organic Long‐Persistent Luminescence from Polymer Films Doped with Chiral Cu(I) Complexes
Abstract The development of polymer materials with circularly polarized organic long‐persistent luminescence (CP‐OLPL) remains challenging yet highly desirable....
Dynamic Iodide Regeneration Enabled by Piperazine‐Tailored PCBM Interfaces for Photothermally Stable and Efficient Inverted Perovskite Photovoltaics
Abstract Molecular iodine release under working conditions remains a major obstacle to the long‐term stability of perovskite solar cells (PSCs). Despite signific...
Hetero‐Composition and Homo‐Structure Decoupling Charge and Phonon Properties in p‐Type Thermoelectric SnAgBiTeSe <sub>2</sub>
ABSTRACT The inherent compromise between charge mobility and phonon transport necessitates hierarchical structural modularity to achieve a high figure‐of‐merit (...
Surface Ferroelectricity in Lead‐Free Nonferroelectric Chiral Perovskites Beyond Neumann's Principle
ABSTRACT According to Neumann's Principle, the chiral‐polar photovoltaic effect (CPPE) is restricted to crystals in one of the five chiral ferroelectric space gr...
Ligand‐Engineered Metal–Organic Cages Boost Charge Separation for Efficient Photocatalytic Synthesis of Hydrogen Peroxide in Pure Water
ABSTRACT Photocatalytic synthesis of hydrogen peroxide (H 2 O 2 ) offers a sustai...
Phosphorus Vacancy‐Engineered Ultrathin RuP Nanosheets for Accelerated and High‐Capacity N‐Ethylcarbazole Hydrogen Storage
Abstract Precisely constructing efficient and durable catalysts for liquid organic hydrogen carriers (LOHCs) is essential for large‐scale hydrogen storage and tr...