Angewandte Chemie International Edition
Articles in this Issue
Engineering Ferroelectric Dipole Superstructure via Phase Transformation for Stable Zinc Anodes
ABSTRACT The commercialization of aqueous zinc ion batteries (AZIBs) is severely hindered by the thermodynamic instability of the Zn anode interface, which leads...
Photocatalytic Radical‐Polar Crossover Enables Modular Access to Bicyclo[2.m.n]Alkane Alcohol Bioisosteres
ABSTRACT The strategic replacement of aromatic rings with saturated bioisosteres has become a pivotal strategy in medicinal chemistry, offering a proven path to improve the metabolic...
Solid‐State Red Carbon Quantum Frameworks With Narrowband Thermally Activated Delayed Fluorescence for Undoped LEDs With High‐Temperature Operational Stability
ABSTRACT High color purity and efficiency of red light‐emitting diodes (LEDs) are essential for true‐color displays. Solution‐processable undoped emission layers...
Tunable Electronic Honeycomb and (Breathing) Kagome Lattices Through Molecular Orbital Design in 2D Metal‐Organic Frameworks
ABSTRACT The pursuit of quantum materials with honeycomb and Kagome lattices hosting flat and Dirac bands has predominantly focused on inorganic crystals, where electronic tunability...
Profiling the Structural Heterogeneity of Monomeric α‐Synuclein From the Single‐Molecule Level Using MspA Nanopores
ABSTRACT Parkinson's disease (PD) is closely associated with the misfolding of α‐synuclein (αSyn) proteins, which remains obscure due to the long‐standing challe...
Millisecond Aliphatic Iodonium‐Claisen Rearrangement Enabling Dual Functionalization of Alkenyl Iodanes
ABSTRACT The evolution of Claisen rearrangements through expansion of the central atom from classical oxygen to sulfur, nitrogen, and phosphorus has reshaped the...
Dual Active Sites in a Single MOF: Achieving High‐Rate and Selective Photocatalytic CO <sub>2</sub> Reduction to Formate With Concurrent Water Oxidation
ABSTRACT A critical challenge in artificial photosynthesis is the limited availability of photocatalysts that effectively integrate active sites for both CO...
Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution
ABSTRACT The oxytocin/vasopressin (OT/VP) neuropeptide signalling system is essential for regulating social behaviour, emotion, learning, and memory, and its dys...
A NIR‐Gated Nanogenerator Enables Low‐Dose Nitric Oxide‐Potentiated Phototherapy
ABSTRACT Light‐activatable nitric oxide (NO) donors are promising for precision cancer therapy but are hindered by premature leakage and a reliance on high dosag...
Anion Size‐Dependent Conformational Folding of Guanidinopropionate: Enabling Tunable Birefringence and Balanced Second‐Harmonic Generation Performance
ABSTRACT The structure–property relationship investigations constitute a fundamental paradigm for the rational design and synthesis of high‐performance functiona...
Photolyzable Polymer Brushes: Subtractive 3D Structuring of Surfaces Using Water and Light
ABSTRACT Polymer brushes are a key technology for designing surfaces, with applications in biomedicine alone including biosensing, cell culture, regenerative medicine, and antibacter...
Unraveling the Stability of N‐Doped Graphene Supported Single‐Atom and Dual‐Atom Catalysts From Pourbaix Diagram
ABSTRACT Single‐atom catalysts (SACs) and dual‐atom catalysts (DACs) exhibit great potential in heterogeneous catalysis. However, studying their stability under practical reaction co...
Single‐Atom Barium‐Mediated Hydrogen‐Bonding Interaction via Mortise‐and‐Tenon Interlock for Rechargeable Biomass Electrooxidation in Pure Water
ABSTRACT Electrooxidative upgradation of biomass‐derived molecules like 5‐hydroxymethylfurfural (HMF) offers a carbon‐neutral blueprint to produce valuable chemi...
Solvent‐Regulated Lattice Elasticity and Pressure‐Induced Multi‐Stimuli Spin‐State Bistability in a Porous Hexagonal Framework
ABSTRACT Spin‐state switching in molecular materials becomes most effective when multiple external stimuli converge on a common structural pathway. Here we repor...
Selective Electrocatalytic Hydrogenation of Phenol to Cyclohexanone at Industrial‐Relevant Current Density
ABSTRACT Electrocatalytic hydrogenation of biomass‐derived phenol represents a sustainable alternative route to produce value‐added chemicals such as cyclohexano...
Precise Spatiotemporal Control of Sensory Nerve Blockade via Light‐Triggered Click‐Release Uncaging of 2′,6′‐Pipecoloxylidide
ABSTRACT The pursuit of non‐opioid analgesics remains a critical priority in pain management. Local anesthetics (LAs) are promising alternatives to opioids, yet conventional agents i...
Electrocatalytic Hotspots in Hierarchical Structures with Ion‐Pump Effect Enable High‐Selectivity Synthesis of 2,5‐Furandicarboxylic Acid From 5‐Hydroxymethylfurfural in Neutral Electrolyte
ABSTRACT The catalytic hotspot effect is a well‐documented phenomenon in photocatalysis, referring to regions with higher catalytic activity at the mesoscale. Wh...
Biomimetic Gradient‐Porous Carbon Enables Sustainable High‐Loading Lithium–Sulfur Batteries by Regulating Polysulfide Chemistry
ABSTRACT To realize the commercial viability of lithium–sulfur (Li–S) batteries, it is imperative to substantially increase the areal sulfur loading of the catho...
Multicyclic D‐Stereospecific Hydrolase Dimer With High Sustained Activity
ABSTRACT Enzymes are powerful catalysts for selective transformations but often suffer from limited stability under operational conditions such as elevated temperature or the presenc...
Formal Allylic C(sp <sup>3</sup> )−H Carboxylation With CO <sub>2</sub> via Copper Metallaphotoredox Catalysis
ABSTRACT Catalytic carboxylation of ubiquitous C─H bonds with CO 2 has been demonstrated as a sustainable and streamlined...
Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen‐Bonded Pairs and Aromatic Components in Palladium(II)‐Based Interlocked and Foldameric Systems
ABSTRACT Nature's exquisite control over structure arises from its use of complex arrays of topologically complicated species capable of forming and functioning...
Ultrawide Potential Window for Ammonia Electrosynthesis on a Bifunctional Metal−Organic Framework Across Broad Nitrate Concentrations
ABSTRACT Adaptability to the fluctuating supply of renewable electricity is one of the most critical challenges in realizing green ammonia electrosynthesis, espe...
Electrochemically Assembled π–π Stacking Organic Radical‐Decatungstate With UV‐SWIR Solar Absorption for Efficiency Solar‐Thermal Conversion
ABSTRACT Solar‐driven interfacial photothermal evaporation is a promising approach for desalination; however, its efficiency is often constrained by the narrow a...
Porous Phenazine‐bridged Tetraoxa[8]Circulenes for Selective Gold Recovery and Heterogeneous Catalysis
ABSTRACT The sustainable recovery of precious metals is critical for securing strategic resources while reducing the environmental footprint of mining. Among the...
The C─C Bond‐Centric Mechanism in Electrocatalytic Waste Polyethylene Terephthalate Valorization
ABSTRACT Plastics have revolutionized our lives, especially polyethylene terephthalate (PET) plastics; however, their exponential consumption and inadequate mana...