Circulation
Articles in this Issue
Abstract 4367883: Uptake of primary and secondary prevention against atherosclerotic disease in the Danish background population
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality worldwide. Primary and secondary prevention are crucial to reduce morbidity and mo...
Abstract 4359694: Lipopolysaccharide-induced Tolerance Educates Hematopoietic Stem Cells to Protect against Cardiac Allografts Rejection
Backgrounds: Heart transplantation remains the gold-standard therapy for end-stage heart failure. However, immune rejection of the transplanted heart critically compromises long-te...
Abstract 4363574: Effects of a health belief model based educational programme on medication adherence among older adults with coronary artery disease: a pilot study
Introduction: Coronary artery disease (CAD) is the leading cause of death worldwide. Medication management is the priority for its secondary prevention. However, medication adheren...
Abstract 4361577: Cilostazol and Pentoxifylline Effect on Cognitive Dysfunctions in Patients with Atherosclerotic Cardiovascular Diseases - A Systemic Review of Clinical Evidence
Introduction: The prevalence of executive dysfunctions and attention deficits is increasingly recognized among patients with atherosclerotic cardiovascular disease (ASCVD). Cilosta...
Abstract 4366651: A Competency-Based Screening Echocardiography Curriculum Designed for Rural American Indian Community Health Representatives
Background: Heart disease is a leading cause of death for American Indians, who face barriers to early diagnosis and accessing cardiac care, particularly in rural areas. To address...
Abstract 4343284: Dual SGLT1 and 2 Inhibition with Sotagliflozin Ameliorates Adverse Cardiac Remodeling and Diastolic Dysfunction in Mice with HCM Due to Tropomyosin E180G Mutation
Background: Hypertrophic cardiomyopathy (HCM) is characterized by adverse cardiac remodeling associated with myocardial hypertrophy, diastolic dysfunction, dysregulated calcium han...
Abstract 4368741: Prospective Study of Changes in High-Molecular-Weight Multimers of von Willebrand Factor During Initiation and Weaning of Temporary Mechanical Circulatory Support
Background: Mechanical circulatory support (MCS) improves outcomes in patients with end-stage heart failure (HF) refractory to medical therapy. However, bleeding is the most common...
Abstract 4370248: Novel Foundation Models for Detecting and Generating Text Reports of Atrial Fibrillation from 12-lead ECGs in a Large Registry
Background: Foundation models have shown strong potential for clinical tasks in early studies. However, few foundation models have been reported that automatically detect atrial fi...
Abstract 4367722: Mitochondrial Transplantation During Ongoing Ischemia May Preserve Neuronal Viability
Introduction: Cardiac and aortic surgery carries a relatively high risk of perioperative stroke. Thrombolysis and thrombectomy are often not feasible in the perioperative setting f...
Abstract 4366061: Global, Regional, and National Trends in Mortality and Disability-Adjusted Life Years (DALYs) Associated with High BMI in Adolescents (1990–2021): A Comprehensive Epidemiological Analysis
Background: High body mass index (BMI) in adolescents is closely associated with various chronic diseases (e.g., cardiovascular diseases, diabetes) and has become a significant glo...
Abstract 4369624: Unscrewing Sign: A Visual Indicator For Atrial Leadless Pacemaker Dislodgment
Backround: The AVEIR DR i2i Study demonstrated safety of atrial leadless pacemakers with a dislodgment rate of only 1.7%. Data on factors influencing dislodgments however remains l...
Abstract 4360543: Atrial Fibrillation and Chronic Kidney Disease: Do Outcomes Worsen with Advancing Renal Dysfunction?
Background: Chronic kidney disease (CKD) and atrial fibrillation (AF) commonly coexist, creating a high-risk population vulnerable to both thrombotic and hemorrhagic complications....
Abstract 4365030: Excess Apolipoprotein B Improves Risk Assessment of All-Cause Mortality in Patients with Aortic Stenosis: Insights from the ARISTOTLE Study
Aims: Discordance analyses showed that apolipoprotein B (apoB) is better for assessing cardiovascular disease risk than low-density lipoprotein cholesterol (LDL-C) and non-high-den...
Abstract 4365445: Scarcity of obesity specialists relative to obesity prevalence in US counties
Introduction: Given the obesity epidemic, access to obesity specialists such as endocrinologists and obesity medicine physicians is paramount for adequate treatment to avoid long-t...
Abstract 4367840: Optimizing the Accuracy of Natural Language Processing Models for Pulmonary Embolism Detection Through Integration with Claims Data: The PE-EHR+ Study
Background: Rule-based natural language processing (NLP) tools are easy to implement and can identify pulmonary embolism (PE) via radiology reports, but their accuracy is limited w...
Abstract 4370842: Incidence Trends of Primary Cardiac Sarcomas in the United States: A SEER-Based Analysis from 2000 to 2021
Introduction: Primary cardiac sarcomas are exceedingly rare and aggressive malignancies, with limited epidemiological data due to their low incidence. This study aims to characteri...
Abstract 4366548: Ferumoxytol Pharmacokinetics in Cardiac Magnetic Resonance
Introduction: Cardiac MRI (CMR) provides a non-invasive, radiation sparing assessment of anatomy and hemodynamics and is essential in caring for patients with congenital heart dise...
Abstract 4367292: Meta-Analysis of Phase III Randomized Controlled Trials to Evaluate the Risk of Cardiac Adverse Events in Patients with Non-small Cell Lung Cancer Treated with Osimertinib Compared to Control
Introduction: Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that is crucial in the treatment of EGFR-mutant non-small cell lung cancer (NSCLC)...
Abstract 4363581: Extracardiac Tamponade Secondary to a Large Paraoesophageal Hernia: A Rare Cause of Hemodynamic Compromise
Introduction: Cardiac tamponade typically results from pericardial fluid accumulation that impairs diastolic filling. Rarely, extracardiac structures can cause similar physiologic...
Abstract 4365053: <i>Design of a Pragmatic Clinical Study of SGLT2-Inhibitors for Exercise-Limited Fontans</i>
Introduction: Children with severe forms of congenital heart disease (CHD), such as single ventricle CHD (SV), are surviving into adulthood. Heart failure (HF) is a common morbidit...
Abstract 4344428: Effect of Empagliflozin on Device-Measured Thoracic Impedance in Patients with Type 2 diabetes treated with an implantable cardioverter-defibrillator: A subanalysis of the EMPA-ICD trial.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to have a beneficial effect on the prognosis of patients with heart failure. The mechanism of the eff...
Abstract 4369981: Thrombus-Derived Exosomal lncRNAs May Link Myocardial Infarction to Increased Post-MI Cancer Susceptibility
Introduction: Clinical and epidemiological studies have shown that patients with myocardial infarction, including non-smokers, have a higher prevalence of non-small cell lung and c...
Abstract 4358517: Chromatin Structural Gene Expression Stratifies Cardiac Cell Populations in Health and Disease
Background: Chromatin structure plays a central role in regulating gene expression and maintaining cellular identity. However, the structural factors driving these processes in car...
Abstract 4365716: Efficacy and Safety of Semaglutide According to Frailty Status in the SELECT Trial
Background: Frailty is common in people with cardiovascular disease (CVD) and may modify the risks and benefits of therapeutic interventions....
Abstract 4369460: Implementing Blood Pressure Kiosks in Community Hubs
Background: Hypertension (HTN) is a major modifiable risk factor for cardiovascular disease and heart failure, contributing to about three-quarters of acute cardiovascular events....