Circulation
Articles in this Issue
Abstract 4372822: A Unique STEMI Etiology: Paradoxical Coronary Embolism
Paradoxical coronary embolism (CE) causes an estimated 4-13% of ST-segment-elevation myocardial infarction (STEMI) presentations. A thromboembolism can originate in the venous system and cross into sy...
Abstract 4368233: Direct Oral Anticoagulants versus Vitamin K Antagonists for Left Ventricular Thrombus Resolution: An Updated Pooled Analysis of Randomized Studies
Introduction: Left ventricular thrombus (LVT) remains a significant complication after anterior MI and among patients with reduced systolic function. VKAs have traditionally been t...
Abstract Sat103: Do Capnography Values Differ Between Bag-Valve-Mask Ventilations and Advanced Airways?
Background: Exhaled end-tidal (EtCO 2 ) is widely measured and may indicate the quality of ventilation in out-of-hospital cardiac arrest (OH...
Abstract 4363010: Monocyte-derived mitochondria-containing extracellular vesicles drive inflammation in heart failure
Introduction: Sterile inflammation is increasingly recognized as a key contributor to heart failure (HF) progression, yet the lack of clearly defined molecular mechanisms has limit...
Abstract 4348798: Comparative Study of Electrophysiologic Pacing Parameters in Patients with Chagas Disease from Honduras
Background: Chagas disease, caused by the parasite Trypanosoma cruzi, is a public health concern in Latin America and an emerging health issue in the United States, leading to sign...
Abstract 4360228: Diagnostic Accuracy of the Systemic Immune-Inflammation Index for Predicting Contrast-Induced Nephropathy in Patients With Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Meta-Analysis
Background: Contrast-induced nephropathy (CIN) is an important cause of morbidity in patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI). A...
Abstract 4370700: SGLT2 Inhibitors in Rheumatic Heart Disease
Introduction: Rheumatic heart disease (RHD) remains a significant contributor to global cardiovascular morbidity, particularly in low- and middle-income populations. Although sodiu...
Abstract 4368022: Navigating Dual Threats: A Case of Left Ventricular Thrombus and Acute Ischemic Stroke
Background: Left ventricular thrombus (LVT) is a known and serious complication of myocardial infarction (MI) and cardiomyopathy, associated with systemic embolism including stroke...
Abstract 4368966: Maternal Exercise Negates the Effects of Maternal PM <sub>2.5</sub> Exposure on Offspring Metabolic and Cardiovascular Health
Cardiovascular disease is the leading cause of death in the United States and stress is a significant risk factor in its pathogenesis. Exposure to stress during critical windows of development, such a...
Abstract Sat406: Association Between Hypoxic-Ischemic Brain Injury on Early Head CT Imaging and Neurologic Outcome After Pediatric Cardiac Arrest
Background: Early quantification of hypoxic-ischemic brain injury (HIBI) after pediatric cardiac arrest may aid in risk stratification, determining candidacy for neuroprotective th...
Abstract 4357481: Modification of the Association of Functional Limitation and cardiovascular diseases by Toxic Metals exposure among US Adults
Background: Functional limitations are common among U.S. adults and are established predictors of cardiovascular disease (CVD). However, it is unclear whether exposure to toxic met...
Abstract 4369128: Insulin Sensitivity and Inflammation: Key Predictors of Cardiovascular Disease in Middle-Aged and Older Adults
Background: Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality in middle-aged and older adults. Both the estimated glucose disposal rate (eGDR), and hs...
Abstract 4370923: Comparative 5-Year Mortality Risk in Stage IV-V Chronic Kidney Disease Patients with Prior Myocardial Infarction: Standard Therapy With versus Without SGLT2 Inhibitors
Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a class of medications that reduce blood glucose levels by inhibiting glucose reabsorption in the proximal conv...
Abstract 4361862: L-canavanine Attenuates Pathological Cardiac Hypertrophy by Directly Targeting the CDC42-JNK Signaling Pathway
Background: Hypertrophic cardiomyopathy (HCM) lacks targeted pharmacotherapy. We employed RNA-seq of human HCM myocardium combined with Connectivity Map screening to identify repur...
Abstract 4344341: Sex- and Race-Based Disparities in Outcomes Following TAVR in Heart Block Patients Requiring Pacemaker Implantation
Background: TAVR is increasingly offered for treatment of aortic stenosis with over 100,000 procedures performed annually in the US. Advanced heart block is a known complication th...
Abstract 4369446: Characteristics Of Cardiac Rehabilitation Referral And Attendance Among Patients With Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry
Cardiac rehab (CR) improves outcomes after ischemic cardiac events, but its role in patients with spontaneous coronary artery dissection (SCAD) remains less understood. Among patients with SCAD, are t...
Abstract 4368733: Long-Term Trends in Ischemic Heart Disease Mortality with Chronic Kidney Disease as a Contributing Cause: A 25-Year Sex-Stratified Analysis Using CDC WONDER
Background: Chronic kidney disease (CKD) is a well-established amplifier of ischemic heart disease (IHD) risk, yet long-term national mortality trends for IHD with CKD as a contrib...
Abstract 4357526: In-Hospital Outcomes of ECMO Use in Takotsubo Cardiomyopathy with Cardiogenic Shock: A Propensity-Matched Analysis of the National Inpatient Sample
Background: Takotsubo cardiomyopathy (TCM) is a transient form of left ventricular dysfunction, in which 10% of patients develop cardiogenic shock, requiring advanced circulatory s...
Abstract 4366027: Hypertension Diagnosis Correlates with Psychological Distress Symptoms, Marital Status, and Insurance Status
Introduction/Background: Hypertension diagnosis and factors such as exercise and education have been correlated, but often for specific population groups (e.g. Whites and African A...
Abstract 4357398: Artificial-Intelligence Based Smart Catheter Guidance for Atrial Fibrillation Ablation: Large Registry Validation
Background: Ablation of atrial fibrillation (AF) by pulmonary vein (PV) isolation has limited success in some patients. However, identifying additional ablation targets in such pat...
Abstract 4360415: Small, Dense LDL-C and Conventional LDL-C Similarly Predict Cardiovascular Risk and Benefit of Alirocumab in Statin-Treated Patients With Recent Acute Coronary Syndrome
Introduction: Small, dense low-density lipoprotein (sdLDL) particles are believed to be a highly atherogenic subfraction of LDL due to prolonged residence time in circulation, grea...
Abstract 4360261: Mechanical Versus Bioprosthetic Surgical Aortic Valves Produce Divergent 3-Year Complication Profiles in Patients ≤ 21 Years
Background: Choice of prosthesis for surgical aortic-valve replacement (SAVR) in children and young adults remains controversial because contemporary, multicenter outcome data are...
Abstract 4366671: Distinct Lipodomic Signatures Identify Imaging-Defined Vulnerable Coronary Plaques in Patients with Myocardial Infarction
Background: Non-invasive identification of high-risk coronary atherosclerosis remains a major clinical challenge. Lipidomics offers a promising tool to uncover metabolic signatures...
Abstract 4371698: Catheter-Directed Thrombolysis Plus Anticoagulation Versus Anticoagulation Alone in Proximal Deep Vein Thrombosis: Focus on Post-Thrombotic Syndrome and Vein Patency. A Systematic Review and Meta-Analysis
Background: Catheter-directed thrombolysis (CDT) followed by anticoagulation has not demonstrated significant benefits in terms of efficacy and safety in major clinical trials. How...
Abstract 4371716: Efficacy of Zilebesiran in Hypertension: A Meta-analysis with Dose-Response and Angiotensinogen Correlation from KARDIA Trials
Background: Zilebesiran, a novel small interfering RNA (siRNA) therapeutic targeting hepatic angiotensinogen (AGT), has demonstrated promising antihypertensive effects in recent ph...