Circulation
Articles in this Issue
Abstract 4361776: Alpha-ketoglutarate facilitates high-fat diet for inflammatory myeloid cell production and atherosclerotic plaque progression via OXGR1
Background: We previously reported that Exendin-4 administration reduced hematopoietic stem/progenitor cells (HSPCs) proliferation and plaque inflammation and size in LDLr...
Abstract 4339601: Elevated Body Mass Index Predicts New-Onset Heart Failure Following Catheter Ablation for Atrial Fibrillation
Introduction: Atrial fibrillation (AF) is the most common sustained arrhythmia and a major contributor to heart failure (HF). Although catheter ablation (CA) reduces HF progression...
Abstract 4358583: Non-Contact Magnetocardiography Localizes Atrial Foci as Accurately as High-Resolution Contact ECG
Background: With the advent of stereotactic radioablation for cardiac arrhythmias, accurate non-contact mapping tools are increasingly important. Magnetocardiography (MCG) is promi...
Abstract 4346395: From Cardiac Emergency to Chemotherapy: Infiltrative Lymphoma Presenting With ST Elevations and Heart Failure
Case Presentation: ST-elevations on electrocardiogram are often due to cardiac emergencies such as a myocardial infarction. However, they may also signal a more occult pathology. A...
Abstract 4367694: Device Therapy in Cardiac Sarcoidosis: A Comparative Analysis of ICD and PPM on Mortality, Hospitalization, and Incident Heart Failure
Background: Patients with cardiac sarcoidosis (CS) generally have a poor prognosis, due to an increased risk for arrhythmias, heart failure (HF), and sudden cardiac death often nec...
Abstract 4372297: Classification of Adjacent Coronary Arterial Plaques Using Late Phase Effective Atomic Numbers and Electron Densities of Focal Pericoronary Adipose Tissue on Contrast Enhanced Spectral Computed Tomography
Introduction: Inflammation in pericoronary adipose tissues (PCATs) may occur focally at adjacent plaque sites in the coronary arterial system as suggested by abnormal late-phase en...
Abstract 4369164: Application of Artificial Intelligence (AI) for Predictive Modelling and Imaging in Cardiac Transplantation - A Systematic Review and Meta-Analysis
Heart transplantation remains the ultimate treatment option for patients with end stage heart disease, but donor supply remains insufficient, thereby complicating its allocation. Traditional scoring s...
Abstract 4346138: Cardiomyocyte-Specific TFEB Deletion Induces Age-Dependent Heart Failure, Exacerbated by Starvation
Background: Malnutrition is a significant stressor in elderly patients, contributing to cardiovascular morbidity. The molecular mechanisms behind the heart’s response to nutrient d...
Abstract 4366386: The Impact of Race/Ethnicity, Education, and Income on Patient Engagement in Adult Congenital Heart Disease Care
Background: It is currently unknown whether patient engagement in adult congenital heart disease (CHD) care is influenced by social determinants of health (SDOH) such as race/ethni...
Abstract 4357705: Motion-Corrected Coronary CT Angiography in Patients with Atrial Fibrillation: A Segment-Based Image Quality Assessment
Introduction: The image quality of coronary CT angiography (CCTA) has improved considerably; however, it remains suboptimal in certain cases, particularly in patients with atrial f...
Abstract 4367514: Association of Cardiopulmonary Resuscitation Strategies with Diffuse Optical Measurements of Cerebral Hemodynamics
Introduction: Hemodynamic-directed cardiopulmonary resuscitation (HD-CPR) targets blood pressure (BP) goals during resuscitation and has shown improved outcomes compared to convent...
Abstract 4371513: Stage 2 heart failure is associated with 24 hour urinary cortisol levels in patients with resistant hypertension
Resistant hypertension (RHTN), defined as blood pressure (BP) above goal despite using ≥3 antihypertensive agents. Patients with resistant hypertension are at an increased risk of heart failure compar...
Abstract Or107: Neuroprotective Effects of Delayed Mitochondrial Transplantation After Cardiac Arrest in Rats
Introduction: We previously demonstrated that mitochondrial transplantation (MTx) administered immediately after resuscitation improved 72-hour survival and neurological outcomes i...
Abstract 4369509: Aldosterone Renin Ratio and Urinary Aldosterone are Potential Biomarkers for Patients with Resistant Hypertension on a High Sodium Diet with Stage 2 Heart Failure.
Resistant hypertension, defined as blood pressure >130/80 mm Hg despite using ≥3 antihypertensive medications, is a well-recognized clinical entity. Patients with resistant hypertension are at an i...
Abstract 4358576: Unveiling a High-Risk Coronary Anomaly in the Peripartum Period
Description of Case: A 21-year-old G5P1 woman at 38.2 weeks gestation presented with worsening exertional chest pain, dyspnea, dizziness, and recurrent syncope. These symptoms have...
Abstract 4362254: N-Terminal pro-B-Type Natriuretic Peptide is an Independent Predictor of Relapse and Adverse Outcomes in Heart Failure with Recovered Ejection Fraction
Background: There are currently no robust clinical markers for assessing prognosis in patients with heart failure (HF) with recovered left ventricular ejection fraction (LVEF)....
Abstract 4360217: Lesion Synergy or a Danger Zone? - Myocardial Perforation After Successive, Co-localized Pulse Field and Radiofrequency Ablations For Atrial Arrhythmia - Report of Two Cases and Discussion of Potential Mechanisms
Introduction: Pulsed Field Ablation (PFA) is becoming popular for Atrial Fibrillation (AF) ablation due to its improved safety profile. However, there are situations where a combin...
Abstract 4365696: Virtual Decentralized Study of Patient Nausea Experience on Anti-Obesity Medication (COSMOS-DIGITAL)
Background: Virtual clinical trials offer a scalable approach to evaluate patient-reported outcomes in real-world settings, particularly related to duration and severity of common...
Abstract 4366110: Persistent Metabolic Remodeling Following Alleviation of Afterload Stress in a Preclinical Model, Despite Recovery of Ejection Fraction and Left Ventricle Hypertrophy
Background and Hypothesis: Aortic stenosis (AS) causes afterload stress and left ventricular hypertrophy (LVH), treatable by aortic valve replacement (AVR) restoring ejection fract...
Abstract 4369082: Population Screening for Polygenic Risk Identifies and Prevents More Cases of Coronary Artery Disease Than Screening for FH
Background: Due to the availability of effective lipid-lowering therapies, familial hypercholesterolemia (FH) case finding is adopted by many healthcare systems. In parallel, polyg...
Abstract 4361514: Mitochondrial Dysfunction in Aging: The Female Heart at Risk
Background: Heart failure is a leading cause of death in postmenopausal women, yet the molecular mechanisms of cardiac decline in females remain unclear. While studies in male mode...
Abstract 4371800: 37,500 man-years of clinical expertise validate the cardio-metabolic benefits of empagliflozin-linagliptin in type 2 diabetes: findings from the amplified consensus
Background and Aims: Perception mapping studies are crucial to understanding real-world applicability of SGLT2 and DPP4 inhibitor combinations in India’s clinical setting. The AMPL...
Abstract 4371466: Epicardial and Visceral Adiposity Define High-Risk Obesity Phenotypes for Cardiovascular Disease: A Harmonized Analysis of Multi-Cohort Imaging and Biomarker Data
Background: Obesity is heterogeneous, with cardiovascular disease (CVD) risk driven by ectopic fat distribution rather than total adiposity. Epicardial Adipose Tissue (EAT) and Vis...
Abstract 4362274: Trends and Disparities in Cerebrovascular Disease and Chronic Kidney Disease-Related Mortality in the United States, 1999–2019: A Nationwide Analysis
Background: Chronic kidney disease (CKD) contributes to an increased risk and severity of cerebrovascular accidents. The mortality trends related to these two conditions have not b...
Abstract 4359837: Clinical and Echocardiographic Predictors of Aortopathy in Patients with Bicuspid Aortic Valve: Insights from a Large Community Cohort
Background: The bicuspid aortic valve (BAV) is the most prevalent congenital heart defect and is frequently associated with aortopathy. The etiology of aortic dilation in BAV is mu...