Abstract 4369981: Thrombus-Derived Exosomal lncRNAs May Link Myocardial Infarction to Increased Post-MI Cancer Susceptibility

Abstract

Introduction: Clinical and epidemiological studies have shown that patients with myocardial infarction, including non-smokers, have a higher prevalence of non-small cell lung and colorectal cancers, pointing to a clinically significant yet poorly understood connection between cardiovascular events and cancer risk. In this study, we investigated thrombus-derived exosomal long non-coding RNAs (Exs-lncRNAs) isolated post-thrombectomy or coronary artery bypass grafting (CABG) to evaluate their oncogenic potential and explore novel molecular contributors to post-MI cancer susceptibility. Hypothesis: We hypothesise that upregulation of thrombus-derived Exs-lncRNAs is associated with increased incidence of cancer in patients with a history of MI. Methods: RNA-seq data from GEO (GSE213115) were analysed in GEO2R. Oncogenic lncRNAs were screened for log2 fold change| > 2 with p < 0.05. Differentially expressed lncRNAs were visualised as bar charts in Excel, and pathway enrichment analysis was performed using Reactome. Results: Transcriptomic profiling of thrombus-derived exosomal RNA identified a subset of significantly upregulated oncogenic lncRNAs, suggesting a potential molecular link between thrombosis and cancer susceptibility. DLEU1 exhibited the highest expression, with a log2 fold change exceeding 3.5. Other prominently elevated transcripts included PCAT14, CASC6, BCL7 B, and BCAS4, each demonstrating a log2 fold change greater than 2.5. Additional lncRNAs such as SIRLNT, TCL6, TPD52, CASC19, and DRAIC also showed substantial differential expression. All lncRNAs met the predefined threshold of statistical significance (|og2 fold change| > 2, p < 0.05). Several of these transcripts have established roles in tumorigenesis, cell proliferation, and immune modulation, highlighting the relevance of thrombus-derived Exs-lncRNAs as candidate mediators of post-MI cancer risk. Conclusion: Our findings suggest that thrombus-derived Exs-lncRNAs may link myocardial infarction to increased cancer risk. The upregulation of oncogenic lncRNAs supports the need for cancer surveillance in post-MI patients, even without conventional risk factors, and highlights Exs-lncRNAs as potential biomarkers for early detection and intervention.