Circulation
Articles in this Issue
Abstract 4366007: Colchicine Reduces Cardiovascular Events in Patients with Increased High-sensitivity C-reactive protein
Background: Atherosclerosis is increasingly recognized as a chronic inflammatory process. High-sensitivity C-reactive protein (hs-CRP) is a well-established predictor of major adve...
Abstract 4366590: Hispanics, Women, and Applicants Ages 45-59 Dominate Boston SNAP Enrollment and Reflect Cardiovascular Disease Risk
Background: Cardiovascular disease (CVD), the world’s leading cause of death, is most commonly prevented through a nutritious diet and the avoidance of harmful substances. Unfortun...
Abstract 4371213: Integrated Radiogenomics Improves Classification of Genetic Hypertrophic Cardiomyopathy
Background: The prognosis of hypertrophic cardiomyopathy (HCM) varies by several factors, including imaging characteristics and genotype, reflecting underlying pathology. Tradition...
Abstract 4362857: Diet and Fecal Microbiota Transplantation Modulates Measurements of Cardiometabolic Health in Aging Animals: Preliminary Results
Background: The Western diet (WD) is associated with the development of diseases such as cardiovascular disease. Shifting from a WD to a health-promoting diet, such as a Mediterran...
Abstract 4365425: Mediation of the Relationship Between Myocardial Replacement Fibrosis and Sudden Cardiac Death by Left Ventricular Ejection Fraction Post-Myocardial Infarction
Background: We aimed to evaluate whether and to what extent left ventricular ejection fraction (LVEF) mediates the relationship between late gadolinium enhancement (LGE) and sudden...
Abstract 4365207: Risk Factors for and Outcomes Following Tube Assisted Feeding in Neonates Undergoing Cardiac Surgery
Introduction: Feeding difficulties are common following neonatal surgery for congenital heart disease (CHD) and often lead to tube assisted feeding (TAF), defined as feeding via en...
Abstract 4357911: Intensive Systolic Blood Pressure Lowering Reduces Cardiovascular Events in Hypertensive Adults Regardless of Metabolic Health Status: Insights from SPRINT
Background: Hypertension often coexists with metabolic abnormalities that increase cardiovascular disease (CVD) risk. While intensive systolic blood pressure (SBP) lowering reduces...
Abstract 4365290: Stroke Prevention with Cerebral Embolic Protection Device Use During Transcatheter Aortic Valve Replacement: A Nationwide, Matched Analysis from TriNetX Database
Background: Transcatheter aortic valve replacement (TAVR) is an established treatment for severe aortic stenosis, yet cerebrovascular complications such as stroke and transient isc...
Abstract 4366797: Use of an Administratively Derived Elder Risk Assessment Score and Long Term Mortality in Older Adults Undergoing Aortic Valve Replacement
Background: Older adults with severe aortic stenosis (AS) are at high risk of mortality unless treated by aortic valve replacement (AVR). The Society of Thoracic Surgery (STS) scor...
Abstract 4367081: Electrocardiogram Abnormalities and Arrhythmias: Analysis of the NHLBI Study on Long-term Outcomes after the Multisystem Inflammatory Syndrome in Children (MUSIC)
Background: Cardiac complications are common in the Multisystem Inflammatory Syndrome in Children (MIS-C); however, data on arrhythmias and other electrocardiogram (ECG) abnormalit...
Abstract 4370414: Radiomics-Based Coronary Heart Disease Classification Using Cine Cardiac MRI in a Bi-Racial Cohort
Introduction: Coronary heart disease (CHD) remains a leading global health burden. Cine cardiovascular magnetic resonance (CMR), the gold standard for evaluating left ventricular (...
Abstract 4366694: Branched Chain Amino Acids Promote Proarrhythmic Electrical Remodeling in hiPSC-derived Cardiac Atrial Microtissues
Introduction: Metabolic syndrome has become a global health crisis affecting 25-35% of adults. Conditions of metabolic syndrome increase the risk of cardiovascular disease, stroke,...
Abstract 4368641: PRDM16 Drives iPSC-Derived Cardiomyocyte Maturation Towards Left Ventricular Commitment
Backround: Human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) technology has advanced translational investigations of heart disease. However, terminal differentiation into...
Abstract 4364369: Spatial T1-Mapping of Cardiac Fibrosis Identifies Causal Protein Drivers through Deep Learning and Mendelian Randomization
Background: Diffuse myocardial fibrosis is a hallmark of heart failure progression. T1 mapping MRI quantifies fibrosis, but conventional mean-T1 metrics blur regional patterns char...
Abstract 4360006: Endothelial SMARCD2 Exacerbates Aortic Aneurysm and Dissection Through Inflammatory Signaling
Background: Aortic aneurysm and dissection (AAD) remain the major causes of cardiovascular mortality, and there are currently no effective pharmacological treatments. The chromatin...
Abstract 4365993: A novel XAI framework for explainable AI-ECG using generative counterfactual-based XAI
Background: To ensure clinical adoption of artificial intelligence (AI)-electrocardiogram (ECG), it is essential to understand why the AI makes certain predictions. Traditional exp...
Abstract Sat105: Airway Opening Index is Associated with Return of Spontaneous Circulation in Swine and Humans with Cardiac Arrest
Introduction: During cardiopulmonary resuscitation (CPR), chest compressions induce oscillations in capnography. The relative magnitude of these oscillations can be quantified by t...
Abstract 4342581: Targeting Serotonin 2B Receptor Signaling Attenuates Disease Progression in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, caused by cardiac myocyte (CM) hypercontractility that induces myocardial hypertrophy and fibrosis. When subjected to pathol...
Abstract 4364806: Antihistamine Treatment to Reduce Microvascular Obstruction and Hemorrhage in Reperfused Myocardial Infarction
Purpose: While mast cells (MCs) have been shown to exacerbate damage in hemorrhagic stroke models by amplifying histamine-driven inflammation, disrupting the blood-brain barrier an...
Abstract 4370453: Incidence and Predictors of Shock in Patients with Noncompaction Cardiomyopathy and Implantable Cardioverter-Defibrillators: A Multicenter Retrospective Study.
Background: Noncompaction cardiomyopathy (NCCM) is a distinct myocardial disorder associated with a high risk of ventricular arrhythmias and sudden cardiac death. Although implanta...
Abstract 4370234: Transcatheter Repair of a Persistent Aortic Root Pseudoaneurysm Using Amplatzer Duct Occluder II and a Covered Stent
Backround: Aortic pseudoaneurysm (PSA) is a rare but life-threatening vascular complication of cardiac surgeries, trauma, and infective endocarditis (IE). It is associated with a h...
Abstract Sat808: Sex Differences in Survival to Discharge and Bystander CPR in Out of Hospital Cardiac Arrest: Do Sex Disparities Exist Among Adults, Adolescents, and Children?
Background: Bystander cardiopulmonary resuscitation (BCPR) is associated with improved survival after out of hospital cardiac arrest (OHCA). Adult females have better outcomes comp...
Abstract 4366866: Neighborhood-Level Nutritional Mobility is Associated with a Reduction in Mortality and MACE Risk Among US Veterans with Established ASCVD
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death in the United States. While healthy dietary habits are known to reduce morbidity and m...
Abstract 4362019: Heatwave-Associated Cardiovascular Mortality in the United States: A Nationwide Analysis (1999–2020)
Introduction: Extreme heat events pose increasing risks for cardiovascular mortality. This study examined trends in cardiovascular deaths associated with heat-related illness in th...
Abstract 4359607: Short-Term Gains, Long-Term Costs: Transcatheter Versus Surgical Aortic Valve Replacement in Heart Failure with Reduced Ejection Fraction
Background: Despite its growing use as a less invasive alternative to SAVR in severe aortic stenosis, outcomes of TAVR in HFrEF patients remain under-investigated....