Circulation
Articles in this Issue
Abstract Sat1301: Golf Course Cardiac Arrest-Not Up to Par Yet?
Background: Out-of-hospital cardiac arrest (OHCA) is a significant public health issue with a <10% survival rate nationally. Golf courses represent the fifth most frequent locat...
Abstract Sun708: The Impact of Intra-Arrest TEE on Epinephrine Administration in In-Hospital Cardiac Arrest: A Resuscitative TEE Collaborative Registry (rTEECoRe) Study
Background: Intra-arrest transesophageal echocardiography (TEE) is increasingly used during in-hospital cardiac arrest (IHCA) to guide resuscitation with evidence that directing th...
Abstract 4365650: Overcoming Barriers For Research Participation In Minority Patients In Lp(a)FRONTIERS EXPANSION: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study To Evaluate Efficacy And Safety Of Pelacarsen In U.S. Black And Hispanic Patients with Elevated Lp(a) And Established ASCVD
Background: Despite increased atherosclerotic cardiovascular disease (ASCVD) risk, Black and Hispanic individuals are underrepresented in ASCVD clinical trials. Black individuals h...
Abstract 4364268: Structural Cardiac Abnormalities Modify Atrial Fibrillation–Associated Heart Failure Risk and Identify a High-Risk Phenotype in Older Adults: The ARIC Study
Background: The combined impact of atrial fibrillation (AF) and structural cardiac abnormalities on heart failure (HF) risk remains incompletely understood in older adults. We exam...
Abstract 4370745: Aggressive Lipid Lowering Differentially Impacts the Vascular Endothelium in Diabetic vs Healthy Individuals. Findings from the American Heart Association Cardiometabolic Health Strategically Focused Research Network
Background: Vascular endothelial cell (EC) damage and subsequent cardiovascular (CV) events occur in patients with type 2 diabetes (T2D) despite aggressive medical therapy. This st...
Abstract 4351296: Early Detection of Chemotherapy-Related Cardiotoxicity Using Global Longitudinal Strain
Background: Global Longitudinal Strain (GLS), derived from speckle-tracking echocardiography, has emerged as a highly sensitive and quantitative marker for detecting early systolic...
Abstract 4369442: Sex- and Age-specific Differences in Lipoprotein(a) and Its Association With Atherosclerotic Cardiovascular Disease in the UK Biobank: A Pragmatic Approach
Introduction: While the ASCVD risk associated to Lipoprotein (a) [Lp(a)] is linear, the 2022 European consensus suggests a one-size fits all pragmatic approach, with Lp(a) cut-offs...
Abstract 4347857: Decreased nitrate reduction capacity of oral microbiota is associated with increased severity of pulmonary hypertension
Background: Pulmonary hypertension (PH) is a fatal condition characterized by elevated pressure in pulmonary artery which could be partly caused by dysfunctional nitric oxide (NO)...
Abstract 4355216: Nonlinear mixed effect modeling of natriuretic peptides and associations with clinical events in interstage infants with single ventricle heart disease
Introduction: Infants with single ventricle disease experience high morbidity and mortality, especially in the interstage period between the first and second palliative surgery. Id...
Abstract 4366034: Fibroblast Dysregulation Drives Atrial Fibrosis of Sorbs2 Knockout Mice
Background: We have previously reported that Sorbs2 (sorbin and SH3 domain 2) knockout mice have significant cardiac structural and electrical remodeling, including atrial enlargem...
Abstract 4341821: Baseline Characteristics and Outcomes of Barlow Syndrome Patients with and without Atrial Fibrillation
Background: Mitral Valve Prolapse (MVP), also known as Barlow Syndrome, is one of the most common valve pathologies. As MVP progresses there is a propensity towards arrhythmias inc...
Abstract 4356396: Paroxysmal atrial fibrillation in the United States population: A cross-sectional analysis of the National Ambulatory Medical Care Survey, 2022
Background: Paroxysmal atrial fibrillation (PAF), defined by episodic and self-limiting arrhythmias, is associated with increased risks of stroke and cardiovascular events. Despite...
Abstract 4361592: State-Level Syncope Driving Restrictions and Crash Risk in Older Adults: A National Comparative Analysis
Background: Syncope is a leading cause of transient loss of consciousness, especially in older adults. Post-syncopal driving restrictions are widely recommended, but the required d...
Abstract 4358220: Patient-derived iPSC-cardiomyocytes harbouring deep intronic <i>MYBPC3</i> variants show features consistent with hypertrophic cardiomyopathy
Background information: Hypertrophic cardiomyopathy (HCM) is the commonest inherited cardiovascular disease. Whilst important for family screening, the utility of genetic testing i...
Abstract 4369862: Trends And Disparities in Acute MI And Acute Respiratory Failure Related Mortality in The United States; A Retrospective Analysis of CDC Wonder Database From 1999-2020
Background: Acute myocardial infarction complicated by acute respiratory failure significantly worsens patient outcomes and remains a leading cause of cardiovascular mortality in t...
Abstract 4352981: Use of Pre-procedural Computed Tomography for Ventricular Tachycardia and Pre-ventricular Contraction Ablations
Introduction: Ventricular arrhythmias are prevalent in patients with both ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) and are associated with increased mor...
Abstract 4369229: Validation of a Novel Reactive Oxygen Species-Targeted SPECT Tracer <sup>67</sup> Ga-Galuminox in Pig Model of Myocardial Ischemia-Reperfusion Injury
Background: Reactive oxygen species (ROS) plays a major role in the pathogenesis of myocardial ischemia-reperfusion injury (IRI). However, molecular imaging probes enabling the in...
Abstract 4367720: Artificial Intelligence to Adjudicate Major Adverse Cardiovascular Events in Clinical Trials
Background: Major adverse cardiovascular events (MACE)—cardiovascular (CV) death, non-fatal myocardial infarction (MI) and non-fatal stroke—are highly relevant clinical outcomes. I...
Abstract 4369132: Physical activity, cardiorenal metabolic diseases and multimorbidity: a prospective study of UK Biobank
Background: Cardiorenal-metabolic multimorbidity (CRMM), defined by the co-occurrence of cardiovascular disease (CVD), chronic kidney disease (CKD), and type 2 diabetes (T2D), pose...
Abstract 4369645: Retinal Vascular and Renal Biomarkers Predict Systemic Cardiovascular and Kidney Disease in the Brazilian Multilabel Ophthalmological Dataset (BRSET)
Background: Cardiovascular disease (CVD) and chronic kidney disease (CKD) are leading global causes of morbidity and mortality, often exacerbated by late diagnosis and limited acce...
Abstract 4367129: Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates pulmonary hypertension
Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary arterial remodelling, leading to right ventricular failure. Accumulating evide...
Abstract 4368968: CRRL094: A novel bispecific designer peptide that protects diabetic heart via AMPK/CIDEC-mediated lipid-lowering effects.
Background: Diabetic cardiomyopathy is a common complication of diabetes, which can progress to symptomatic heart failure. Current conventional medical therapy does not reverse the...
Abstract 4366712: Long term outcomes of Beta blocker use in Takotsubo Syndrome- A Propensity Matched Analysis
Background: Beta blockers are often used in patients with Takotsubo syndrome to reduce sympathetic nervous system activation, but their long-term effects on outcomes are not well d...
Abstract 4367869: Effectiveness of Nifedipine Versus Labetalol for Postpartum Hypertension Control: A Systematic Review and Meta-analysis
Background: Postpartum hypertensive disorders are a major cause of maternal mortality and hospital readmission. If untreated, elevated blood pressure can lead to complications such...
Abstract 4367249: Incident Comorbidities May Impact Rhythm Control Strategies and Outcomes After Catheter Ablation of Atrial Fibrillation: The Arrhythmia Recurrence and Rhythm Control Strategies After Catheter Ablation of Newly Diagnosed Atrial Fibrillation (ARRC-AF) Study
Background: Rhythm control with catheter ablation (CA) of atrial fibrillation (AF) leads to reverse remodeling of AF substrate. Comorbidities may impact this process and outcomes....