Circulation
Articles in this Issue
Abstract 4371126: ZIP Code Stratification of Social Determinants of Health and Cardiovascular Disease Burden
Introduction: ZIP code is one of the strongest predictors of cardiometabolic health, often surpassing genetic and clinical factors. Regional disparities in areas such as environmen...
Abstract 4368144: Outcomes of Drug-Coated Balloons versus Second-Generation Drug-Eluting Stents in In-Stent Restenosis: A Real-World Perspective
Background: The evidence comparing drug-coated balloons (DCBs) and second-generation drug-eluting stents (DES) for the treatment of coronary in-stent restenosis (ISR) is primarily...
Abstract 4363543: Phenotypic Evolution of Early to Late Cardiac Amyloidosis with Serial Cardiac Magnetic Resonance
Introduction: Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy associated with significant morbidity and mortality. The natural history and optimal surveillance strategie...
Abstract 4373167: The Hidden Heart Failure Epidemic: Cocaine Use Disorders and Their Rising Toll Across 204 Nations (1990–2021)
Background: Cocaine use is a growing global public health concern, with its use rising steadily over the past decades. As a potent sympathomimetic agent, cocaine is linked to a bro...
Abstract 4369243: Vascular Imaging for ASCVD Risk Stratification: Predictive Value of Carotid Plaque, Coronary Artery Calcium, and Retinal Biomarker (Dr.Noon CVD)
Background: Carotid ultrasound is convenient and widely used for CVD risk assessment. Plaques—especially in the internal carotid artery (ICA) or bulb—predict atherosclerotic cardio...
Abstract 4363963: Practice Variations in the Management of Hemodynamically Significant Patent Ductus Arteriosus in Neonates (hsPDA): A Survey of Neonatologists and Pediatric Cardiologists
Background: Management of hsPDA in neonates remains controversial, with substantial variation in clinical practice among neonatologists&cardiologists. Definition of hsPDA is ba...
Abstract 4373689: Familial Partial Lipodystrophy: An Overlooked Etiology of Heart Failure
Background: Familial partial lipodystrophy (FPLD) is a rare genetic disorder often underrecognized in clinical practice. Given its phenotypic overlap with common metabolic disorder...
Abstract 4365239: Cardiac Cachexia: A Case of Esophageal Compression
Clinical Course: A 72-year-old male with a history of hypertrophic obstructive cardiomyopathy (HOCM), chronic atrial fibrillation, septal myomectomy, and mitral regurgitation prese...
Abstract Sun401: Use of an EHR-based care signature pathway may improve neuroprognostication assessment adherence in cardiac arrest survivors
Introduction: Withdrawal of life sustaining therapy (WLST) due to perceived poor neurologic prognosis, is the leading cause for death following cardiac arrest. Guidelines recommend...
Abstract 4369655: Cardiovascular Risk Factors in South Asian Young Adults in the United States: The MASALA-2G Second Generation Study
Introduction: South Asian populations are at enhanced ASCVD risk per clinical atherosclerotic cardiovascular disease (ASCVD) prevention guidelines, because they experience excess A...
Abstract 4369481: An Unusual Etiology of Tamponade: The Role of Solid Pericardial Debris
Case Description: A 71-year-old male presented to the hospital for dyspnea and chest discomfort for the past 2 weeks. He has a history of AAA status post stent and current tobacco...
Abstract 4360886: Update to Non-invasive, Automated Approach to Estimate Septal Curvature as a Surrogate of Mean Pulmonary Arterial Pressure for Pediatric Pulmonary Hypertension Patients
Background: Pediatric pulmonary hypertension can be diagnosed by echocardiography and right heart catheterization, but cardiac MRI-based septal curvature (SC) measurement can also...
Abstract 4369849: ECG-based risk prediction of sudden cardiac arrest in patients with atrial fibrillation
Introduction: Both individually as well as in composite risk scores, specific markers on the 12-lead ECG are associated with increased sudden cardiac arrest (SCA) risk. Atrial fibr...
Abstract 4365028: HIV Antiretroviral Therapy and Drinking Water Contaminant Exposures Induce Cardiac Function Changes in Women of Childbearing Age
Objective: The majority of individuals living with human immunodeficiency virus (HIV) are female. Although combined antiretroviral therapy (cART) can greatly improve prognosis and...
Abstract 4367702: Evaluating The Causal Role Of SGLT2 Inhibition In Cerebrovascular Disease: A Systematic Review And Meta-Analysis Of Mendelian Randomization Studies
Introduction: Cerebrovascular disease, including stroke and cerebral small vessel disease, remains second leading cause of death and disability worldwide. Sodium-glucose cotranspor...
Abstract 4364194: Adverse Pregnancy Outcomes Are Associated with Incident Peripheral Artery Disease, Results from the Women’s Health Initiative.
Background: Women with a history of adverse pregnancy outcomes (APOs) have an increased risk for heart disease and stroke; however, data on risk for peripheral arterial disease (PA...
Abstract 4357683: Prognostic Impact of Heart Failure in Acute Limb Ischemia: A Propensity Score Matched Analysis of National Inpatient Sample Data (2016–2020)
Background: Heart failure (HF) is a known risk factor for adverse outcomes in cardiovascular diseases, but its impact on acute limb ischemia (ALI) outcomes remains underexplored. T...
Abstract 4370466: Case title: Superficial Myocardial Bridging Continuing as Intracavitary Course and Presenting as Angina-Like Chest Pain in a Young Female
Introduction: Superficial myocardial bridging (MB) and intracavitary course (IC) of the left anterior descending artery (LAD) are considered benign conditions. Small segment bridgi...
Abstract 4362263: Factors Associated with Physician Modifications to Automated ECG Interpretations
Introduction: Accurate automated diagnoses contribute to the improvement of clinical workflows and the enhancement of patient care. Commercially available automated electrocardiogr...
Abstract 4369934: Cardiac Autoimmunity in Pediatric Single Ventricle Congenital Heart Disease
Background: Heart-specific autoimmunity has emerged as a key contributor to cardiac dysfunction and heart failure. In pediatric patients with single ventricle (SV) physiology, the...
Abstract 4366535: Targeting Endothelial CD47 to Mitigate Atherosclerosis by Restoring PPARγ-Dependent Cholesterol Efflux and Efferocytosis
Introduction: CD47, an anti-phagocytic protein, is upregulated in human and murine atherosclerotic plaques. While systemic CD47 blockade reduces atherosclerosis by enhancing effero...
Abstract 4369231: Timing of Cardiovascular and Kidney Benefits with Finerenone in Heart Failure and Chronic Kidney Disease with Type 2 Diabetes
Background: The nonsteroidal mineralocorticoid receptor antagonist finerenone has been shown to reduce adverse clinical outcomes in persons with heart failure (HF) and chronic kidn...
Abstract 4365190: Automated and Accurate Deep Learning Model for Myocarditis Detection with Cardiac Magnetic Resonance Images Background
Background: Myocarditis is an inflammatory disease of the myocardium resulting from a wide range of infectious or noninfectious causes. Cardiac magnetic resonance (CMR) imaging has...
Abstract 4360892: Relationship of smoking to inflammation, coronary artery disease severity, and cardiovascular outcomes in patients with stable chest pain: Insights from the PROMISE randomized trial
Background: Smoking is related to systemic inflammation and is a major modifiable risk factor for coronary artery disease (CAD) and adverse cardiovascular (CV) outcomes. However, t...
Abstract 4371113: Differential Gene Expression Signatures Underlying Postoperative Atrial Fibrillation
Introduction: Postoperative atrial fibrillation (poAF) is a serious complication following cardiac surgery, contributing to increased ICU and hospital length of stay, heightened st...