Circulation
Articles in this Issue
Abstract 4365297: Investigator-Initiated Exploratory Clinical Trial of Cell-Based Angiogenic Therapy Using Injectable Cell Scaffold (ICS-001) Combined with Autologous PBMCs in Chronic Limb Threatening Ischemia
Chronic limb-threatening ischemia (CLTI), a severe complication of lifestyle-related diseases such as diabetes and chronic kidney disease, remains a highly prevalent and challenging condition. Angioge...
Abstract 4369178: Causal Proteomic Consequences of Clonal Hematopoiesis: Integrated Human Genetic and Murine Validation
Background: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic stem cells with preleukemic driver mutations, is a novel risk...
Abstract 4363128: Protein Tyrosine Phosphatase 1B as a Novel Regulator of Myofilament Function in Disease
Phosphorylation of myofilament proteins is a critical regulatory mechanism for cardiac contractility and kinetics and is known to be dysregulated in heart failure (HF). Most studies focus on kinase dy...
Abstract 4363387: Porcine Model of Biventricular Pressure-Volume Loop Assessment during Impella 5.5 Support
Introduction: The Impella 5.5 is frequently employed to provide temporary mechanical circulatory support as bridge to recovery or durable therapy. Optimization of device management...
Abstract 4364791: GLP-1 Receptor Agonists Lower Readmission Rates Without Impacting Mortality After CABG in Adults with Congenital Heart Disease
Background: Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed for type-2 diabetes and obesity, with emerging evidence of cardiovascular benefits. Howeve...
Abstract 4357278: Race and Socioeconomic Status Influence Prehospital Treatment and Diagnosis of Patients With ST-Elevation Myocardial Infarction
Prompt cardiac reperfusion reduces morbidity and mortality following an ST-elevation myocardial infarction (STEMI). Evidence demonstrates hospital-based treatment metrics for patients suffering STEMI...
Abstract 4362613: Asiatic Acid, A Novel Peroxisome Proliferator-Activated Receptor Alpha Agonist, Ameliorates Cardiac Hypertrophy By Reducing Reactive Oxygen Species Accumulation
Background: Cardiac hypertrophy is a leading cause of morbidity and mortality worldwide. Being a chronic myocardial disease, it comes with a plethora of changes inside the cellular...
Abstract 4368485: BMP3 Overexpression Attenuates Pulmonary Arterial Hypertension
Backgound: Pulmonary arterial hypertension (PAH), a rare and progressive subtype of pulmonary hypertension (PH), leads to right heart failure and, ultimately, death. PH is defined...
Abstract 4358248: Patient-specific iPSC-derived Cardiomyocytes Reveal Variable Phenotypic Severity in a <i> KCNH <sub>2</sub> </i> p.Y427H Parent-Proband Trio
Background: Type 2 Long QT Syndrome (LQT 2 ), caused by KCNH 2...
Abstract 4350593: TRAM Deletion Reprograms Neutrophils to Resolve Inflammation and Attenuate Atherosclerosis
Atherosclerosis is a leading cause of morbidity and mortality globally, and neutrophils have emerged as key players in the progression and resolution of vascular inflammation. Although neutrophils are...
Abstract 4369872: An Examination of LGBT Non-Discrimination Laws and CVD Risk Among US Veterans
Background: Over 550 Anti-LGBT (lesbian, gay, bisexual, transgender) bills were introduced at the state-level during the 2025 legislative sessions. Increased state-level anti-LGBT...
Abstract 4357297: Lyme Disease and Its Cardiovascular Complications: When Time Slowly Runs Out
Description of case: A 68 y.o. woman presented to the ER with NYHA class IV heart failure symptoms and productive cough, already evaluated by pulmonologist and initiated on cefurox...
Abstract 4356954: Causative Organism Predicts Diagnostic Utility of TTE in Bacteremia-Associated Endocarditis
Introduction: Transthoracic echocardiogram (TTE) is a critical diagnostic tool for detecting infective endocarditis (IE) in patients with bacteremia. Despite being a common sequela...
Abstract 4372519: A Hypertrophic Cardiomyopathy-Based Model Estimate of the Prevalence of Danon Disease in the United States
Introduction/Background: Danon disease (DD) is an ultra-rare X-linked disorder caused by LAMP2 protein deficiency. It frequently manifests as hypertrophic cardiomyopathy (HCM), alo...
Abstract 4368845: Greater Involvement in Shared Decision-Making is Associated with Better Self-Reported Health in US Adults and Those Living with Cardiometabolic Conditions
Background: Shared decision-making (SDM) has been recommended to promote person-centered outcomes among adults with cardiovascular diseases. Yet, the associations between SDM and s...
Abstract 4344136: The Genetic Basis of Early Mortality in Neonates with Single Ventricle Disease: An NC-DEFINE Prospective Observational Cohort Study
Background: Single ventricle disease (SVD) is the most severe form of congenital heart disease. Despite surgical advances improving survival, heart failure (HF) remains a key contr...
Abstract 4363968: Impact of Glucagon-Like Peptide-1 Receptor Agonists on 5-Year Risk of Major Amputation and Cardiovascular Outcomes in Diabetic Patients with Chronic Limb-Threatening Ischemia
Background: Type 2 diabetes mellitus (T2DM) is a major risk factor for chronic limb-threatening ischemia (CLTI). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstra...
Abstract 4357647: VC108, a GPR39 Blocker, Increases Coronary Blood Flow and Inhibits the Vascular Effects of 15-Hydroxyeicosatetraenoic Acid
Background: We previously showed that GPR39 is present in cardiac arteriolar vascular smooth muscle cells (VSMCs) and that 15-hydroxyeicosatetraenoic acid (15-HETE) is the endogeno...
Abstract 4370189: Hypoxemia Beyond the Heart: A Case of Hepatopulmonary Syndrome Masquerading as Cardiac Dyspnea
Hepatopulmonary syndrome (HPS), a serious yet underrecognized cause of hypoxia in patients with liver disease, can mimic cardiopulmonary pathology. Multimodal cardiac imaging plays a critical role in...
Abstract 4343571: Sex-Specific Metabolomic Signatures Following LVAD Implantation in Ischemic and Non-Ischemic Cardiomyopathies.
Background: Changes in metabolic pathways have been described in patients with heart failure (HF) and reduced ejection fraction. Selected patients with end-stage HF are candidates...
Abstract 4365953: Multi-Omics Approach Identifies SMPD1 as a Therapeutic Target Potentially Mediating Aortic Aneurysm via Ceramide Metabolism
Introduction: Aortic aneurysms (AAs), including thoracic (TAA) and abdominal (AAA) types, are associated with a high risk of dissection and rupture, with no pharmacological therapi...
Abstract 4367804: Dietary 15-Hydroxyeicosatetraenoic Acid Causes Pulmonary Hypertension By Promoting Stearoyl-CoA Desaturase-1 Mediated Pulmonary Artery Endothelial Cell Dysfunction
Background: Pulmonary hypertension (PH) is a fatal pulmonary vascular disease characterized by progressive increase in pulmonary arterial pressure, which leads to right ventricular...
Abstract 4370244: Prevalence of Common ECG Findings in a Typical East African Cohort
Introduction/Background: People with HIV (PWH) in high-income countries experience an increased risk of ischemic heart disease and arrythmia. Little is known, though, about the rel...
Abstract 4348439: Re-evaluating the Reliability of Size as a Biomarker for Monitoring Paraganglioma Activity
Case Description: A 38-year-old woman with a history of hypertension presented in 2016 with right-sided abdominal pain. Imaging revealed a 1.7 x 2.3 cm left periaortic mass near th...
Abstract 4363637: Different Criteria of Prediabetes and Cardiovascular Risk and Mortality: A Prospective Cohort and Mendelian Randomization and Imaging Study in the UK Biobank
Background: Prediabetes, an intermediate metabolic state preceding diabetes, independently accelerates cardiovascular pathology through dysglycemia-driven mechanisms. This study ev...