Circulation
Articles in this Issue
Abstract 4368696: <i>Pichia kudriavzevii</i> : An Unexpected Cause of ICD Vegetation in an Immunocompetent Patient
Background: Fungal endocarditis is uncommon, making up an estimated 1-3% of cases. Risk factors for this are prosthetic heart valves, prior heart surgery, and IV drug use. Fungal s...
Abstract 4366264: The importance of social and clinical variables as risk factors for 30-day readmissions following acute myocardial infarctions
Background: Hospital readmissions are costly, burdensome to patients, and are often preventable. Patients recovering from an acute myocardial infarction (AMI) face varying risks of...
Abstract 4365166: Computational Simulations of Coronary Artery Bifurcation Stenting Using Realistic Plaque Distribution and Materials
Background: Percutaneous coronary intervention (PCI) of bifurcated coronary lesions is associated with higher complication and restenosis rates due to complex vessel geometry and p...
Abstract 4371441: Functional Capacity, Average Daily Step Count, and Angina among Women with Coronary Microvascular Dysfunction Compared to Obstructive Coronary Artery Disease and Healthy Control
Background: Approximately 50% of women with ischemia but no obstructive coronary artery disease have coronary microvascular dysfunction (CMD), a condition associated with adverse c...
Abstract 4364291: Latexin Promotes Neointimal Hyperplasia by Enhancing SMC Proliferation and Macrophage Migration through Activation of MAPK Signaling
Background: Neointimal formation remains a primary cause of cardiovascular diseases such as atherosclerosis and restenosis, despite advancements with drug-eluting stents. Latexin (...
Abstract 4367513: Towards Apple Watch-based Remote Monitoring of Stroke Patients for New Onset Atrial Fibrillation
Background: New-onset atrial fibrillation (AFib) increases the risk of recurrent stroke. Early identification of stroke survivors at short-term risk may guide monitoring and preven...
Abstract 4357761: Declining Mortality from Myocardial Infarction in Young and Middle-Aged Americans and the Impact of the COVID-19 Pandemic
Background: Acute myocardial infarction (AMI) represents a significant component of cardiovascular disease (CVD) mortality among the young and middle-aged populations of the United...
Abstract 4358170: The Impact of Inflammatory Cumulative Burden on the Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) has been a significant global public health challenge, with chronic inflammation playing a central role...
Abstract 4366949: Relations Of Inflammatory Biomarkers With Incident Clinical Peripheral Artery Disease In Older Adults
Background: Peripheral artery disease (PAD) is a vascular condition marked by arterial narrowing that affects 8.5 million adults in the U.S. Contributions of circulating biomarkers...
Abstract 4368953: Comparative Safety and Efficacy of Acoramidis Versus Tafamidis in Transthyretin Amyloid Cardiomyopathy: A Systematic Review
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is an under-diagnosed and life-threatening progressive infiltrative cardiomyopathy characterized by the abnormal depositi...
Abstract 4337093: Association between atherogenic index of plasma and long-term prognosis in patients with Cardiovascular–kidney–metabolic syndrome stages 4: a retrospective cohort study involving 7,672 individuals.
Background: The atherogenic index of plasma (AIP) is closely associated with various metabolic disorders, cardiovascular diseases, and chronic kidney disease, and it has also been...
Abstract 4368911: Role of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in a hPSC Model of First Heart Field-Derived Ventricular Development
Background: Hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) is a marker of the first heart field (FHF) but is absent in the second heart field (SHF) during ear...
Abstract 4364992: To Cath or Not to Cath? A Loeys-Dietz Clinical Dilemma
Loeys-Dietz syndrome (LDS) is a connective tissue disorder that affects the arterial system causing aneurysms, tortuosities, and dissections. Spontaneous coronary dissection (SCAD) in this population...
Abstract Sat702: Increasing Biomarkers of Systemic Inflammation after Pediatric Cardiac Arrest are Associated with Hospital Mortality: A Preliminary Report from a Prospective Cohort Study
Introduction: Post-cardiac arrest syndrome (PCAS) includes a sepsis-like inflammatory state. Best characterized in adults, elevated levels of plasma biomarkers including interleuki...
Abstract 4363321: Association of Left Atrial Dysfunction With Ventricular Arrhythmias in the ARIC Study
Introduction: Left atrial (LA) myopathy indicated by worsening LA function has been well-established as a predictor of atrial fibrillation (AF) and other atrial arrhythmias. Howeve...
Abstract 4339614: Ischemic Stroke in Atrial Fibrillation and Hypertrophic Cardiomyopathy: Insights From a Large Propensity Score Matched Analysis
Background: Incidence of ischemic stroke (CVA) in patients with atrial fibrillation (AF) and hypertrophic cardiomyopathy (HCM) is not well known....
Abstract 4365250: Intravascular Imaging-guided Percutaneous Coronary Intervention in Patients With High Platelet Reactivity
Introduction: High platelet reactivity (HPR) phenotype, as well as complex coronary artery lesion increases the incidence of atherothrombotic events after percutaneous coronary int...
Abstract 4371446: A Trauma-Informed Approach to Patient Care
Introduction/Background: Advanced care planning (ACP) is a prophylactic decision-making process on potential palliative and end of life health care, which strengthens individualize...
Abstract 4367574: Equity in Transplantation: Evaluating Outcomes in Cancer-Associated Cardiomyopathy
Background: With improved cancer survival, therapy-related cardiomyopathies have become a leading cause of end-stage heart failure requiring heart transplantation (HT). However, po...
Abstract 4371827: Geographic and Racial Disparities in Stroke-Related Mortality from Infective Endocarditis Among Young Adults (1999–2023): A CDC WONDER Analysis
Introduction: Stroke is a common complication of infective endocarditis (IE). Previous studies have explored trends in IE-related mortality; however, trends in IE and stroke-relate...
Abstract 4371433: Cardiovascular Outcomes Associated with GLP-1 Receptor Agonists in Obese Adults Without Diabetes: A Propensity-Matched Real-World Study
Background: Obesity is a well-established risk factor for atrial fibrillation (AF) and adverse cardiovascular outcomes. Glucagon-Like Peptide 1 receptor agonists (GLP-1 RAs), initi...
Abstract 4361462: RN0361, an siRNA Directed Against ApoC3 Demonstrates Potent and Durable Reduction of ApoC3 and Triglyceride Over 6 Months in the Clinic
Background: Apolipoprotein C3 (ApoC3) plays a significant role in regulating triglyceride levels and is becoming recognized as a contributor to cardiovascular disease (CVD) risk, p...
Abstract 4372926: Left Ventricular Diastolic Collapse in a Loculated Malignant Pericardial Effusion
Background: Acute cardiac tamponade occurs when rising intrapericardial pressure compresses the heart, most commonly affecting right-sided chambers. However, in postoperative or ma...
Abstract 4360533: Implementation of a Multicomponent Intervention Increases Acute Myocardial Infarction Diagnosis and Evidence-Based Treatment in a Tanzanian Emergency Department
Introduction: The burden of acute myocardial infarction (AMI) is growing in Tanzania, but AMI is frequently misdiagnosed, and uptake of evidence-based AMI care is suboptimal, leadi...
Abstract 4362311: Slow Coronary Flow is Associated with Left Ventricular Diastolic Dysfunction and Left Atrial Dilation
Introduction: Slow coronary flow (SCF) is a coronary microvascular disorder characterized by delayed opacification of coronary vessels on angiography in the absence of obstructive...