Circulation
Articles in this Issue
Abstract 4367181: New Diagnosis of Hemochromatosis in Patients Undergoing Genetic Evaluation of Early-onset Atrial Fibrillation
Background: Genetic testing is now recommended for select patients with early-onset atrial fibrillation (AF). Hemochromatosis is an autosomal recessive syndrome that occurs in pati...
Abstract 4362017: Patient Preferences for Antithrombotic Therapy for Stroke Prevention in Device-Detected Subclinical Atrial Fibrillation: A Probability Trade-Off Interview Study
Introduction: Device-detected subclinical atrial fibrillation (AF) is common in patients with implanted cardiac rhythm devices. The ARTESiA trial demonstrated that in patients with...
Abstract 4367128: Hypertensive Diseases Related Mortality in middle-aged adults (25-54 years) in the United States from 1999 to 2020
Introduction: Hypertension is considered to contribute to 685,000 deaths annually in the United States as per the CDC. Nearly half of adults (119 million) have high blood pressure...
Abstract 4369020: Ablation vs. Antiarrhythmic Drugs in Atrial Fibrillation: Real-World Treatment Gaps, Outcomes, and Equity Challenges
Background: Although catheter ablation (CA) has become a cornerstone in rhythm control for atrial fibrillation (AF), real-world practice continues to lean heavily on antiarrhythmic...
Abstract 4367476: STAT3-Mediated Metabolic Adaptation is Essential for Exercise-Induced Physiological Cardiac Growth
Introduction: Physical exercise induces physiological cardiac growth and protects the heart against pathological stresses. However, the molecular mechanisms underlying these cardia...
Abstract 4363741: Seasonal Variation in New Onset Atrial Fibrillation with Phenotypic Variations in Outcomes, and Projected Trends from a Time Series Analysis
Background: Seasonal variations has been described for new onset atrial fibrillation (NOAF) affecting outcomes. Our study aimed to trend seasonal variation in AF admissions using a...
Abstract 4371842: Impact of Leadless Versus Transvenous Pacemakers on Tricuspid Valve Function: A Propensity-Matched Multicenter Time-to-Event Study (The LEADLESS-TR)
Background: Leadless pacemakers (LPMs) have emerged as an alternative to transvenous pacemakers (TVPMs), particularly in patients with certain comorbidities. However, their long-te...
Abstract 4367065: High VExUS Score Predicts In-Hospital Mortality in Acute Heart Failure: A Systematic Review and Bayesian Meta-Analysis
Background: As systemic congestion takes center stage in the prognosis of acute heart failure (AHF), the Venous Excess Ultrasound (VExUS) protocol has emerged as a compelling tool...
Abstract 4367223: Acoustic Biomarkers Harvested from 911 Calls Differ among Patients with Cardiac and Non-Cardiac Chest Pain
Introduction: More than 10 million 911 calls are made for non-traumatic CP each year, yet only 15% lead to a confirmed cardiac diagnosis. Identifying cases of cardiac chest pain (C...
Abstract 4370812: Characterizing the Continuum of Untreated Cardiovascular Risk Among Young Adults Without Established Cardiovascular Disease: Evidence from a Real-World Health System and a Population-Based Cohort
Introduction: Contemporary cardiovascular (CV) prevention frameworks prioritize individuals who meet treatment thresholds based on estimated risk or clinical indicators. However, a...
Abstract 4363216: RUNX2, IBSP, and SPP1 as Key Molecular Nodes in Calcific Aortic Stenosis: Transcriptomic Diagnostics and Emerging Therapeutic Targets.
Calcific aortic stenosis (CAS) is the most common valvular disease in the elderly, with no approved pharmacological treatment to slow or reverse its progression. This study combined a systematic liter...
Abstract 4366311: Cardiovascular-Kidney-Metabolic Syndrome: Comparing Outcomes between Sodium glucose co-transporter 2 inhibitor and Glucagon like petide 1 receptor analogue use - A Real world propensity Matched Analysis
Introduction: Cardiovascular-Kidney-Metabolic (CKM) syndrome, defined by the interplay of cardiovascular disease, chronic kidney disease, and metabolic dysfunction, is common yet u...
Abstract 4337457: Tok Protease Activity Regulates Cardiac Morphogenesis via Slit Fragmentation
Congenital heart defects (CHDs) affect nearly 1% of live births in the United States, yet the developmental mechanisms that guide early heart formation remain poorly understood. Mutations in the evolu...
Abstract 4370592: Outcomes of Open Cardiac Surgery in Patients with Preoperative Iron Deficiency Anemia: A Propensity-Matched Multicenter Retrospective Analysis
Introduction: Iron deficiency anemia (IDA) may adversely affect perioperative outcomes due to impaired oxygen delivery and reduced immune function. However, data on the specific im...
Abstract 4364396: Modulation of Myocardial Histidyl Dipeptide Synthesis Alters Cardiac Function During Heart Failure
Background: Cardiomyocytes produce histidyl dipeptides such as carnosine (β-alanyl-L-histidine) and anserine (β-alanyl-N π -methylhistidine)...
Abstract 4338116: FibriCheck Detection Capabilities for Atrial Fibrillation: A Multicenter Validation Study
Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with significant morbidity, mortality, and healthcare spending. Despite medical advan...
Abstract 4357397: Repetitive Ventricular Response During Radiofrequency Ablation of Left Posterior Fascicular Ventricular Tachycardia: A Reliable Indicator of Success or Mere Observation?
Background: Idiopathic left posterior fascicular ventricular tachycardia (LPF-VT) is commonly treated with radiofrequency ablation (RFA), where non-inducibility of VT post-ablation...
Abstract 4347552: Statin Use Mitigates Androgen Deprivation Therapy-Associated Coronary Atherosclerosis in Prostate Cancer: A Secondary Analysis of the REVELUTION Randomized Clinical Trial
Introduction: Prostate cancer (PCa) is the most common cancer in men. Androgen deprivation therapy (ADT) is the primary systemic therapy for PCa, with over 500,000 men in the US be...
Abstract Sat503: Booster Training and Self-Efficacy of ICU Staff for Resuscitation of Postoperative CABG Patients
Background: Deaths related to surgery are more likely in the postoperative period than during surgery itself with cardiac arrest occuring in up to 8% of post-op cardiac patients. H...
Abstract 4361877: Bismuth Nanoparticle-Infused Bioresorbable Graft Enables Multimodal Computed Tomography and Photoacoustic Imaging-Based Monitoring and Promotes Vascular Regeneration
Background: Bioresorbable polymeric grafts lack capabilities for non-invasive long-term monitoring, leading to late detection of complications like stenosis or aneurysm. Hence, we...
Abstract 4365649: Sortilin inhibition mitigates the severity of calcific aortic valve disease in a minipig model
Introduction: Calcific aortic valve disease (CAVD) is a progressive condition that leads to aortic stenosis, heart failure, and premature death. Emerging evidence indicates that ox...
Abstract 4371696: Pulsed Field Ablation Is Not Functionally Benign: Left Atrial Impact Mirrors Radiofrequency Ablation
Introduction: Pulsed field ablation (PFA) offers a non-thermal approach to atrial fibrillation ablation, aiming to preserve tissue structure and function. However, its effects on l...
Abstract 4369038: Remote Patient Monitoring Is Associated with a 30.6% Reduction in Annual Total Cost of Care Among Hypertension and Diabetes Patients
Background: Remote patient monitoring (RPM) has emerged as a promising strategy to improve outcomes and reduce costs among high-risk chronic disease populations. However, real-worl...
Abstract 4357514: Adiponectin and Adiponectin/Leptin Ratio Associate with Cardiometabolic Risk in South Asian Americans: Updates from the MASALA Study
Introduction: South Asian Americans face a disproportionately high burden of atherosclerotic cardiovascular disease (CVD) compared to other racial/ethnic groups. Adipokines, which...
Abstract 4339871: Inflammasome-mediated Galectin-3 release limits its protective role in macrophage lysosomal damage response during atherosclerosis
Galectin-3 (Gal3) is a β-galactoside-binding lectin widely recognized as a secreted inflammatory biomarker in cardiovascular disease, with significantly elevated circulating levels in patients with at...