Circulation
Articles in this Issue
Abstract 4369237: Decoding Endocardial Fibroelastosis with Differentially Regulated miR-100-5p and miR-503-5p
Background: Endocardial fibroelastosis is a unique form of subendocardial fibrosis leading to diastolic dysfunction and heart failure. The root cause of EFE is the fibrogenic trans...
Abstract 4369344: STX-1200: A Novel CRISPR-CasX based Gene Editing Approach for Potent and Selective Reduction of Lipoprotein(a) in Multiple Preclinical Models
Background: Elevated lipoprotein(a) [Lp(a)] is a prevalent, causal risk factor for cardiovascular disease, with no approved therapies to lower its levels. Circulating Lp(a) concent...
Abstract 4367199: Seconds to Save: Recognizing Type A Intramural Hematoma Before It’s Too Late
Case Presentation: A 56-year-old woman with a history of hypertension and type 2 diabetes mellitus presented with acute, severe chest pain radiating to the back, which began while...
Abstract 4338723: The role of Phosphodiesterase 1A in aortic aneurysm and dissection
Background: Aortic aneurysm and dissection (AAD) are life-threatening diseases characterized by progressive degradation of the aortic wall. The loss of contractile phenotype in vas...
Abstract 4364631: Pump Speed Adjustment During Exercise Improves Peak Oxygen Consumption and Pump Flow Compared To Fixed Speed In Left Ventricular Assist Device Patients: A Systematic Review and Meta-Analysis
Background: Adjusting left ventricular assist devices (LVAD) pump speed during exercise may enhance hemodynamics and improve functional capacity in patients with advanced heart fai...
Abstract 4364767: Two Mechanisms, One Valve: A Structural and Hemodynamic Comparison of Rheumatic and MAC-Induced Mitral Stenosis
Background: Mitral annular calcification (MAC) and rheumatic heart disease represent two distinct mechanisms leading to mitral stenosis (MS). MAC is a common degenerative process a...
Abstract 4369224: Artificial Intelligence ECG-Extracted Features Predict Microvascular Obstruction in ST-segment Elevation Myocardial Infarction
Background: Microvascular obstruction (MVO) is a critical predictor of adverse outcomes including mortality and the development of heart failure following ST-segment Elevation Myoc...
Abstract 4351238: Use of GLP-1 is Associated with Improvement in Mortality Rates in ESKD Patients
Background: In a recent clinical trial, Semaglutide, a GLP-1 agonist, reduced the risk of clinical outcomes and death from cardiovascular causes in patients with chronic kidney dis...
Abstract 4365447: Engulfment of apoptotic mesenchymal stromal cells enhances the reparative property of macrophages
Background and Aim: Transplantation of mesenchymal stromal cells (MSCs) has been developed as a promising strategy for treating ischemic heart diseases. Transplanted MSCs will not...
Abstract 4361536: Diverging Trends in Cardiovascular Mortality: A Comparative Analysis of GBD and CDC WONDER for Five Conditions (1999–2020)
Background: Understanding cardiovascular mortality is key for shaping public health priorities. Two major sources in the U.S.—CDC WONDER and the Global Burden of Disease (GBD) stud...
Abstract 4360518: Metabolomic Signatures of Symptom Severity in Black Adults with Heart Failure
Introduction: Heart failure (HF) disproportionately affects Black adults. Despite therapeutic advancements, symptom burden remains a major driver of healthcare utilization and redu...
Abstract 4359655: Sex-Specific Outcomes of Left Atrial Appendage Occlusion Versus Oral Anticoagulation: A Systematic Review and Meta-Analysis
Background: Oral anticoagulation (OAC) is the standard for stroke prevention in atrial fibrillation (AF), but high bleeding risk or intolerance limits its use in some patients. Lef...
Abstract 4363994: Measured Fontan conduit size and functional capacity: An analysis of the FORCE registry
Total cavo-pulmonary connection (Fontan) is the final stage of single ventricle palliation. In patients with an extracardiac (EC) Fontan, the synthetic conduit connecting the inferior vena cava to the...
Abstract 4364130: Trends in Cardiovascular Mortality in Kidney Cancer Patients: Insights from CDC WONDER, 1999–2020
Background: Kidney cancer remains a significant contributor to cancer-related morbidity and mortality. Current projections estimate that the annual incidence will reach approximate...
Abstract 4357575: “Atrialized” Minimally Invasive Transcatheter Mitral Valve-In-MAC Replacement to Prevent Outflow Tract Obstruction
A 71-year-old female with a history of severe aortic stenosis status post aortic valve replacement with a 23mm bioprosthetic valve and aortic root enlargement with bovine pericardial patch 6 years pri...
Abstract 4363728: Air pollutants, road traffic noise, and risk of valvular heart disease: a UK Biobank-based prospective study
Introduction: Air and noise pollution are recognized public health concerns. However, their long-term impact on valvular heart disease (VHD) remains unclear....
Abstract 4360271: Prognostic Accuracy of the Systemic Immune-Inflammation Index for Atrial Fibrillation Recurrence Following Catheter Ablation: A Systematic Review and Meta-Analysis
Background: Atrial fibrillation (AF) recurrence remains a common and clinically significant complication following CA. Identifying reliable biomarkers for stratifying recurrence ri...
Abstract 4366789: Natural History Nomograms of Duchenne Cardiomyopathy by Cardiac Magnetic Resonance Imaging
Introduction: Duchenne Muscular Dystrophy (DMD), an X-linked disorder resulting in skeletal and cardiac myopathy, typically leads to death from 20-40 years of age. Cardiac magnetic...
Abstract 4365877: Lp(a) Screening in FQHCs: A National Implementation Science Approach
Background: Lipoprotein (a) [Lp(a)] is genetically inherited, causal and prevalent risk factor for Atherosclerotic Cardiovascular Disease (ASCVD). Despite a 10%−20% prevalence of e...
Abstract 4364972: The Kaiser Permanente Cardiovascular Health Enhancement and Monitoring for Oncology (KP CHEMO) Study
Background: There are nearly 19 million cancer survivors in the U.S., projected to reach 22 million by 2030, many at increased risk for cardiovascular disease complications....
Abstract 4370057: Comparison of non-calcified to calcified plaque ratio versus noncalcified plaque burden to predict adverse cardiovascular outcomes in the CONFIRM2 registry
Background: While the burden and morphological features of coronary atherosclerosis are both important drivers of major adverse cardiovascular events (MACE), there remains uncertai...
Abstract 4370596: Incidental Detection of Enormous Esophageal Dilation Mimicking Aortic Pathology in a Hypertensive Stroke Survivor: A Diagnostic Challenge
Background: Incidental imaging findings often lead to the discovery of silent but clinically relevant conditions. An unusually distended esophagus may mimic vascular anomalies on e...
Abstract 4359386: Divergent Remodeling from Adjacent <i>TNNC1</i> N-terminal Variants: Mechanistic Insight into Sarcomere Dysfunction in Inherited Cardiomyopathies
Mutations in TNNC1 , encoding cardiac troponin C (cTnC), are associated with dilated (DCM) and hypertrophic (HCM) cardiomyopathy. The N-terminal domain of cTnC...
Abstract 4372001: Hospital performance can overcome the impact of socioeconomic distress on failure to rescue in cardiac surgery
Background: Failure to rescue (FTR), or death after a surgical complication, is an important indicator of surgical quality and outcomes. The likelihood of FTR is closely associated...
Abstract 4370394: Thirty-Day Readmissions After Hospitalization for Takotsubo Syndrome: A Nationwide Readmissions Database Analysis
Background: Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is an acute but typically reversible condition characterized by transient left ventricular dysfunction, o...