Circulation
Articles in this Issue
Abstract 4360135: Telemetry Optimization: Improving Efficiency and Adherence to Cardiac Monitoring Guidelines
Background: The American Heart Association (AHA) provides telemetry guidelines for hospitalized patients. However, 43% of telemetry orders lack an AHA-recommended indication. Telem...
Abstract 4361628: Prognostic Value of Preprocedural Pulmonary Artery to Ascending Aorta Ratio in Patients Undergoing Mitral Valve Transcatheter Edge-to-edge Repair
Background: The pulmonary artery to ascending aorta ratio (PA/Ao), measurable by chest computed tomography (CT) was associated with clinical outcomes in patients with heart failure...
Abstract 4347173: RSPO1-Mediated Macrophage Polarization Drives Ventricular Remodeling and Heart Failure after Myocardial Infarctio
Background/ Hypothesis: Macrophages exhibit remarkable heterogeneity and plasticity under diverse pathological conditions]. Precise regulation of macrophage function and phenotypic...
Abstract 4362346: Transforming Heart Failure Care with EHR-Based Alerts: Accurate Diagnosis and Improved GDMT Uptake
Introduction/Background: Guideline-directed medical therapy (GDMT) is central to managing heart failure (HF) with reduced ejection fraction (HFrEF), offering up to a 73% reduction...
Abstract 4360068: Cardio-Kidney-Metabolic Syndrome in Chronic Total Occlusion Percutaneous Coronary Intervention
Background: Cardio-kidney-metabolic (CKM) syndrome, characterized by coronary artery disease, diabetes mellitus (DM), obesity, and chronic kidney disease (CKD), is linked to poor c...
Abstract 4362832: Fibrosing Mediastinitis in Pregnancy: A Rare Case with Antepartum Hemoptysis and Airway Obstruction
Background: Fibrosing Mediastinitis (FM) is a rare, progressive disorder characterized by fibrous tissue growth in the mediastinum, the compartment containing the heart, major bloo...
Abstract 4360205: Higher Expectations for Recovery Are Associated with Greater Coping Self-Efficacy After a Cardiac Intensive Care Unit Stay
Background: Expectations for recovery following cardiac intensive care unit (CICU) hospitalization may shape how patients engage in care and cope with challenges after discharge. E...
Abstract 4358985: Right Ventricular Dysfunction Strongly Predicts Thromboembolism and Major Bleeding in Tetralogy of Fallot and Pulmonary Atresia with Intact Ventricular Septum
Introduction: Complex congenital heart disease (CHD) patients with atrial arrhythmias have higher rates of morbidity and mortality compared to less complex CHD patients. This study...
Abstract 4367371: Endogenous YAP Activation Promotes Myocardial Repair After Myocarditis by Suppressing IFN-γ/STAT1 Signaling
Background: Adult mammalian hearts have limited regenerative capacity, yet most myocarditis patients experience natural healing. Activating intrinsic cardiac healing mechanisms is...
Abstract Sun903: Out-of-hospital cardiac arrest systems of care perspectives of initiating a drone as first responder automated external defibrillator program in counties within North Carolina and Virginia
Introduction: Bystander defibrillation remains low throughout the US (1-4%). The REciprocal InnovationS TO ImpRovE Cardiovascular CARE in Rural America (RESTORe-CARE) project is de...
Abstract 4367750: Burden of Peripheral Artery Disease and its attributable risk factors from 1990 to 2021: A comparative analysis of Low versus High Socio-demographic Index (SDI) Regions
Background: Peripheral artery disease (PAD) is an atherosclerotic narrowing of peripheral arteries, particularly in the lower limbs. The burden of PAD is affected by various modifi...
Abstract 4371444: Restoring LAMP2B in the Heart via Gene-Corrected HSPCs: A Novel Therapy for Danon Disease
Background: Danon disease is a fatal X-linked lysosomal storage disorder caused by loss of lysosome-associated membrane protein 2 (LAMP2), leading to severe cardiomyopathy and inte...
Abstract 4344879: Diagnostic Performance of the ATTR-CM Mayo Score in Black and Hispanic individuals: Findings from SCAN-MP
Background: The Mayo transthyretin amyloidosis cardiomyopathy (ATTR-CM) score was developed to screen for ATTR-CM and guide referral for 99mTc-pyrophosphate imaging. However, its p...
Abstract 4367548: Non-Inferior Safety of Same-Day Discharge Following Percutaneous Left Atrial Appendage Closure: An Updated Meta-Analysis
Background: Same-day discharge (SDD) protocols are increasingly adopted in structural heart interventions due to their potential to reduce hospital length of stay and associated cl...
Abstract 4336880: Integrative Genomic and Transcriptomic Analysis of Hypertension in a Taiwanese Population
Background: Hypertension is a leading risk factor for cardiovascular disease and is highly prevalent in Asian populations. However, most genome-wide association studies (GWASs) and...
Abstract 4365334: The Associations of Energy Intake with All-cause Mortality among Adults with Cardiometabolic Diseases: A National Prospective Cohort Study
Background: Dietary risks, including energy intake, contribute to disease burden. We examined associations of energy intake with all-cause mortality in American adults with cardiom...
Abstract 4361155: Serum Iron Predicts Long-Term Cardiovascular Outcomes in Diabetic Patients with Coronary Artery Disease, Independent of Iron Status
Background: Iron status is crucial in the pathophysiology of coronary artery disease (CAD) and diabetes, with both iron deficiency and overload linked to adverse outcomes. However,...
Abstract 4365864: Post-Discharge Outcomes and Healthcare Costs for Patients Hospitalized for Heart Failure with Transthyretin Amyloid Cardiomyopathy: Findings From GWTG–HF
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with high risk for heart failure (HF) hospitalization. However, little is known regarding post-discharge ou...
Abstract 4361500: Atherosclerotic Cardiovascular Diseases, Myocarditis and Atrial Fibrillation Among Patients on Immune Checkpoint Inhibitors
Introduction: Cardiovascular events are increasingly reported in patients on immunotherapy with myocarditis being the most common. There is growing evidence suggesting that immune...
Abstract 4360103: Regulation by N-acetyl lysyltyrosylcysteine amide of the immunomodulatory network improves cardiac function in type 2 diabetic mice
Introduction: Diabetic cardiomyopathy (DCM) is associated with the development of overt heart failure driven by complex, interdependent pathophysiological mechanisms. Although a se...
Abstract 4371264: Sex-Based Differences in Atrial Fibrillation Catheter Ablation among Patients with Heart Failure
Introduction: Clinical trial data and professional guidelines support rhythm control strategies over rate control in patients with comorbid atrial fibrillation (AF) and heart failu...
Abstract 4367547: Plasminogen Activator Inhibitor-1 Governs Arterial Aging
Background: Plasminogen activator inhibitor-1 (PAI-1), encoded by SERPINE1 , contributes to age-related cardiovascular diseases (CVD) and ot...
Abstract 4359292: Aldosterone dysregulation is associated with uncontrolled hypertension: Insights from the real-world BREAKTHROUGH Hypertension Study
Background: Association between serum aldosterone levels and uncontrolled hypertension in a real-world diverse population remains understudied....
Abstract 4371727: A systematic review and meta-analysis comparing the effect of remote ischemic preconditioning on patients with intermittent claudication
Introduction: remote ischemic preconditioning has been shown to enhance skeletal muscle resistance to ischemia. This type of ischemia is a key contributor to intermittent claudicat...
Abstract 4369656: Intersecting Inequities: Mapping Racial and Social Vulnerability Hotspots in U.S. Cardiogenic Shock Mortality
Backround: Cardiogenic shock [CS] remains highly lethal. Whether county-level structural vulnerabilities, as captured by the CDC Social Vulnerability Index [SVI], modify racial mor...