Circulation
Articles in this Issue
Abstract 4340986: Basis of Myocardial Elasticity Derived from Cardiac MRI in a Swine Model of Ischemic Heart Failure
Background: The progression of CHF after MI has been traditionally evaluated by serial changes in EF. However, mechanical parameters can provide a greater insight into cardiac func...
Abstract 4370186: Non-Bacterial Thrombotic Endocarditis and Intraventricular Small Vessel Thromboembolic Occlusion Mimicking ICI-Myocarditis in a Patient Treated with Pembrolizumab
Case Description: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with immune-related adverse events, including cardiovascular toxicity. Whil...
Abstract 4361108: Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population
To understand the genetic basis of heart failure (HF) in the Japanese population, we performed genome-wide association studies (GWASs) comprising 16,251 all-cause HF cases, 4,254 HF with reduced eject...
Abstract 4363954: Renal Congestion After Transcatheter Aortic Valve Implantation Is Associated With Adverse Outcomes in Patients With Severe Aortic Stenosis
Background: Renal congestion is recognized as an important factor related to adverse outcomes in heart failure patients. Although transcatheter aortic valve implantation (TAVI) imp...
Abstract 4364135: A Cross-scale Causal Machine Learning Framework Pinpoints <i>Mgl2</i> <sup>+</sup> Macrophage Orchestrators of Balanced Arterial Growth
Postnatal development requires precise coordination across molecular, cellular and tissue scales. However, existing methods often fail to resolve the causal hierarchies that underlie this coordination...
Abstract 4363352: Deletion of <i>Npr1</i> in Cardiomyocyte Provokes Cardiac Hypertrophy and Dysfunction in Mutant Mice
Introduction: Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) is a major biologically active natriuretic peptide (NP) receptor that synthesizes intracellular second-mes...
Abstract 4347078: Reclaiming Life Amid Constraint: The Ventricular Assist Device Experience
Background: Ventricular assist device (VAD) implantation requires adoption of complex self-management routines, including device monitoring, dressing changes, assessing for complic...
Abstract 4369483: Phenotype Based Machine Learning Approach for Enhancing Long Term Cardiovascular Disease Mortality Risk Stratification in Obstructive Sleep Apnea: A Longitudinal Cohort Study
Background: Obstructive sleep apnea (OSA) affects about 25% of middle-aged adults and more than doubles cardiovascular disease (CVD) mortality via sympathetic activation, oxidative...
Abstract 4366114: Lipin1 Protects the Ischemic Myocardium by Regulating Lipid Homeostasis
Background: Lipid metabolism plays a crucial role in in cardiovascular disease pathophysiology. Lipin1 is a key regulator of lipid metabolism. In the nucleus, lipin1 acts as a tran...
Abstract 4362727: Computational Modeling Predicts Benefits of Pro-efferocytic Therapy in Human Atherosclerosis
Efferocytosis is impaired in atherosclerosis and recognized as a hallmark of plaque vulnerability. Defective efferocytosis can be reactivated by ‘macrophage checkpoint inhibitors’. Only the key ‘don’t...
Abstract 4337522: Prognostic Impact of Right Ventricle-Pulmonary Artery Coupling in Patients with Severe Calcific Mitral Stenosis
Background: Right ventricular function is strongly associated with the mortality in mitral stenosis (MS). The ratio of tricuspid annular plane systolic excursion (TAPSE)/pulmonary...
Abstract 4366227: Cumulative LDL-C Exposure and Presence of CAC at Midlife: A Combined Predictor of Long-Term Cardiovascular Risk
Background: Emerging evidence suggests that cumulative exposure to low-density lipoprotein cholesterol (LDL-C), rather than a single measurement, may be a stronger determinant of f...
Abstract Sat1403: National Trends in Cardiac Arrest Mortality Among Adults Aged 25 and Above Living with HIV in the United States: Insights from CDC WONDER Database from 2004 to 2023
Background: Despite advances in HIV treatment, cardiac arrest remains a significant cause of mortality in people with HIV. However, national trends and disparities in cardiac arres...
Abstract 4364722: Arterial Duplex Ultrasound Impacts Endovascular Outcomes: Unintended Consequences of Patient Harm From the 2023 and 2025 Amputation Reduction and Compassion Act
Background: The Amputation Reduction and Compassion (ARC) Act of 2023 and 2025 supports arterial duplex ultrasound (DUS) as an initial screening tool to detect and treat peripheral...
Abstract 4345250: Vascular Remodeling In A Murine Model Of COPD-PH Induced By Exposure To Cigarette Smoke During Hypoxic Conditions
Background: The severity of chronic obstructive pulmonary disease (COPD) is significantly worsened by the development of pulmonary hypertension (PH), a complication associated with...
Abstract 4340505: Dissecting The Origins Of An Incidental Aortic Pseudoaneurysm
Background: An aortic pseudoaneurysm (APA) is a contained rupture of the aortic wall that is often asymptomatic and detected as an incidental imaging finding. APAs can result from...
Abstract 4371266: FRAGILITY INDICES OF LIPID-LOWERING RANDOMIZED CONTROLLED TRIALS
Introduction: Lipid lowering therapies have value in reducing adverse atherosclerotic cardiovascular disease (ASCVD) events and are recommended in primary and secondary prevention...
Abstract 4368981: Early GLP-1 Receptor Agonist Initiation Reduces Major Cardiac and Renal Events in Older Adults with Type 2 Diabetes Without Prior Cardiovascular or Renal Disease: A Target Trial Emulation
Background: GLP-1 receptor agonists (GLP-1 RAs) are known to reduce cardiovascular risk in type 2 diabetes. However, their effectiveness in primary prevention, particularly among o...
Abstract 4369151: Localized Calcium Depletion at The Spindle Poles Is Essential For M-Phase Progression In Cardiomyocytes
Introduction: Cardiomyocyte proliferation is fundamental to heart development and regeneration. Although calcium release from the sarcoplasmic reticulum (SR) is well-known to drive...
Abstract 4361974: Safety Outcomes in Heart Failure Patients Undergoing Colonoscopy Screening for Cardiac Transplant Evaluation
Age-appropriate colon cancer screening is recommended for cardiac transplant evaluation. Patients with advanced cardiomyopathy may require inpatient evaluation and inotropes or mechanical circulatory...
Abstract 4363995: Primary Graft Dysfunction in Pediatric Transplant: Insights from the Organ Procurement and Transplantation Network
Introduction: We describe the incidence of primary graft dysfunction (PGD) in the pediatric heart transplant population. This has been difficult to quantify because of uncertain de...
Abstract 4359604: Model-Based Evaluation of LDL-C Lowering for Laroprovstat (AZD0780), An Oral Small Molecule PCSK9 Inhibitor, and Rosuvastatin
Introduction: Approximately 70% of patients who are at high or very high risk for an atherosclerotic CV event fail to achieve their treatment targets. Laroprovstat (AZD0780), an or...
Abstract 4358887: Trends and Disparities in Acute Myocardial Infarction Related Mortality Among Adults with Chronic Kidney Disease in the United States, 1999–2023
Background: Acute myocardial infarction (AMI) in patients with chronic kidney disease (CKD) is a major health concern in U.S. adults. This study examines trends and disparities in...
Abstract 4369061: Protective Effects of Carnosineon Skeletal Muscle Function and Physical Endurance During Heart Failure
Background: Exercise intolerance is a cardinal symptom of heart failure contributing to poor quality of life and increased mortality. Extensive evidence shows skeletal muscle abnor...
Abstract 4365964: GLP-1 Eligibility and Use Among the Medicaid Population
Introduction: The use of glucagon-like peptide-1 receptor agonist (GLP-1RA) has transformed the management of cardiovascular kidney metabolic syndrome, but the large number of indi...