Circulation
Articles in this Issue
Abstract 4357628: Gaps in Stroke Risk Documentation for Veterans with Incident Atrial Fibrillation
Background: Documentation of atrial fibrillation (AF)-associated stroke risk with the CHA 2 DS 2 -VA...
Abstract 4367134: Sex Disparities in Acute Myocardial Infarction in Japan: A 40-Year Study from the Miyagi (Regional) AMI Registry
Background: In the U.S., acute myocardial infarction (AMI) mortality remained higher in women than in men after 1984 but declined markedly in the past decade. However, long-term se...
Abstract 4372672: Severe Pulmonary Hypertension in a Young Adult with Congenital Diaphragmatic Hernia: A Challenging Case of Multifactorial Developmental Lung Disease.
Background: Pulmonary hypertension (PH) associated with congenital diaphragmatic hernia (CDH) remains a major cause of morbidity and mortality, particularly in survivors with persi...
Abstract 4366701: The Role of Venous Excess Ultrasound (VExUS) in Predicting AKI and Diuresis in Acute Decompensated Heart Failure
Introduction: Venous Excess Ultrasound (VExUS), a novel Doppler-based scoring system to evaluate venous congestion, may provide insight into how and when to diurese patients with a...
Abstract 4367076: Trends in Cardiovascular Mortality by Educational Attainment in the United States, 2010-2023
Background: Educational attainment is an important socioeconomic marker. Recent trends in cardiovascular (CV) mortality by educational attainment are unknown. This study examines C...
Abstract 4365578: Finerenone and liver fibrosis assessed by fibrosis-4 (FIB-4) index in patients with heart failure and mildly reduced or preserved ejection fraction: Results from the FINEARTS-HF trial
Background: Liver fibrosis is increasingly recognized as a comorbidity in heart failure (HF), driven by venous congestion, hypoperfusion, systemic inflammation, and metabolic distu...
Abstract 4369163: Elevated levels of estimated low-density lipoprotein triglycerides is associated with risks for atherosclerotic cardiovascular disease and type 2 diabetes
The relationship between LDL-C and the risk of developing T2D has been a subject of significant research interest. Observational studies and clinical trials have suggested that lower LDL-C levels, par...
Abstract 4369085: Impact of Family History and Polygenic Risk Scores on Cardiometabolic Disease Risk
Introduction: Cardiometabolic diseases (CMD) remain a leading contributor to global morbidity and mortality. While both family history (FH) and polygenic risk scores (PRS) are esta...
Abstract Sun1104: When in Doubt Shout it Out; Increasing Knowledge of Rapid Response Team Utilization
Introduction/Background: After recognizing delays in calling Rapid Response Team (RRT) this project idea was formed to increase clinicians’ knowledge and comfortability regarding i...
Abstract 4363716: The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: A multicenter randomized study (HYPIC trial)
Introduction: Chronic inflammatory cardiomyopathy (infl-CMP) is a persistent cardiac disorder that often arises from the progression of acute myocarditis. This condition is marked...
Abstract 4339808: Impact of Left Atrial Strain on Outcomes of Severe Mitral Regurgitation due to Severe Mitral Annular Calcification
Background: Mitral annular calcification (MAC) is a progressive degenerative condition characterized by calcium deposition along the mitral valve annulus. It is increasingly preval...
Abstract 4370599: Global Trends in Congenital Heart Disease Mortality: A 31-Year Analysis from the Global Burden of Disease Study (1990–2021)
Introduction: Congenital heart diseases (CHDs) are among the most common birth defects worldwide and represent a growing global health concern. These conditions range from common d...
Abstract 4364513: Comparison of ChatGPT-4o and OpenEvidence for Clinical Decision Support in Transcatheter Tricuspid Valve Interventions
Background: Artificial intelligence (AI) tools are increasingly used to support clinical decision-making. However, data on their performance in complex, subspecialty areas such as...
Abstract 4365980: Real-World analysis of systemic vascular resistance using a cuffless photoplethysmography-based device for 24-hours ambulatory blood pressure monitoring across diverse patient groups
Introduction: Photoplethysmography-based (PPG) devices represent a significant advancement in noninvasive cardiovascular monitoring. These cuffless technologies enable assessment o...
Abstract 4371052: A Rare Manifestation of Drug-Induced Lupus: Hydralazine-Induced ANCA Vasculitis and Persistent Pericarditis
Introduction: Drug induced lupus (DIL) is an autoimmune reaction triggered by medication, mimicking systemic lupus erythematosus with symptoms like arthralgia, fever, and malar ras...
Abstract 4364017: Left Atrial Passive Strain Rate by Cardiac Magnetic Resonance Imaging Better Reflects Left Ventricular Diastolic Function Than Left Atrial Reservoir Strain: A Cross-Sectional Study in a Post-COVID-19 Cohort
Introduction/Background: Left ventricular (LV) diastolic function is a key prognosticator in both disease and the general population. Given the physiological atrioventricular coupl...
Abstract 4346086: Sex differences in the outcomes of rheumatic mitral stenosis in multicenter registry
Background: While sex differences have been observed in various valvular heart diseases, data on rheumatic mitral stenosis, the most common form globally, remain limited....
Abstract 4346181: The Impact of Genotype on Phenotypic Severity and Survival in Pediatric Dilated Cardiomyopathy: a report from the Pediatric Cardiomyopathy Registry
Introduction: Monogenic causes of dilated cardiomyopathy (DCM) are commonly identified in children. While DCM frequently presents with symptomatic heart failure (HF), whether an id...
Abstract 4357414: Towards More Sensitive Detection of Cardiovascular Proteolytic Signals: A Substrate Phage-Display Based Approach
Introduction: Dysregulated protease activity is a key early contributor to cardiovascular diseases, with neutrophil serine proteases (NSPs) implicated in the pathogenesis of stroke...
Abstract 4370063: Immune and Inflammatory Dysregulation Across the Single Ventricle Spectrum: A New Frontier for Therapeutic Innovation&Intervention
Introduction: While heart failure (HF) is a leading cause of death and indication for transplant in single ventricle congenital heart disease (SV) patients, the molecular mechanism...
Abstract Sat404: TRIM3-Mediated Ubiquitination of GPX4 Exacerbates Neuronal Ferroptosis After Cardiac Arrest
Background: Ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a key role in neuronal injury after cardiac arrest (CA) and cardi...
Abstract 4369712: Metabolomic Profiling in a Murine Model of HFpEF Reveals Fuel Metabolism Alterations and Accumulation of Gut-Derived Metabolites
Background: HFpEF is a highly prevalent yet poorly understood syndrome that lacks disease-modifying therapies. While dysregulation of fuel substrate metabolic pathways is recognize...
Abstract 4357964: Comparing Traditional and Newer Definitions of Obesity in Relation to Incident Cardiovascular Disease and Cancer Risk: A Prospective Cohort Study
Background: Traditional body mass index (BMI)-based obesity definition (BMI ≥30 kg/m 2 ), while indicative of health risks, shows variable v...
Abstract 4370982: Disparities in Demographic Representation in Heart Failure Clinical Trials: A Systemic Analysis of Enrollment Patterns and Their Impact on Health Equity
Introduction: Heart failure with reduced ejection fraction (HFrEF) remains a leading cause of morbidity, mortality, and healthcare expenditures in the U.S. Despite its disproportio...
Abstract 4373182: Trends and Disparities in Mortality Due to Congenital Circulatory Anomalies in the United States: A Nationwide Analysis from 1999 to 2020
Background: Congenital circulatory anomalies remain a significant cause of mortality in the United States, especially among infants and young children. Understanding long-term mort...