Circulation
Articles in this Issue
Abstract 4366791: Trends and Disparities in Metabolic Syndrome-related Mortality in the United States (2000–2019): A Nationwide Analysis
Background: Metabolic syndrome (MetS) is a well-established risk factor for cardiovascular events and is associated with increased all-cause mortality. Given limited data available...
Abstract 4370641: Association of Catheterization Timing with In-Hospital Outcomes in OHCA Patients with NSTEMI: A National Analysis
Background: The optimal timing of cardiac catheterization in patients experiencing out-of-hospital cardiac arrest (OHCA) presenting with non-ST-elevation myocardial infarction (NST...
Abstract 4369552: Role of the Polycystin-1 C-Terminus in Regulating Cardiomyocyte Protein Synthesis
Introduction: Polycystin-1 (PC1) is a large transmembrane protein expressed across the body. While PC1 mutations are responsible for ~85% of autosomal dominant polycystic kidney di...
Abstract 4361433: Sex-Stratified Trends in Mortality from Cardiogenic Shock–Complicated Acute Myocardial Infarction: A 25-Year National Analysis Using CDC WONDER (1999–2023)
Background: Cardiogenic shock (CS) remains the most lethal complication of acute myocardial infarction (AMI), with high mortality despite advances in revascularization and mechanic...
Abstract 4365977: Gestational Diabetes Mellitus Impairs Endothelin-1-Mediated Vasoconstriction in Fetal Placental Arteries
Introduction/Background: Gestational diabetes mellitus (GDM) is the most common metabolic complication during pregnancy. It increases the risk for endothelial dysfunction, hyperten...
Abstract 4367472: Longitudinal Proteomic Signatures of Age-Related Blood Pressure Progression and Cardiovascular Risk in a Multi-Ethnic Cohort
Background: Hypertension (HTN) is a leading cause of cardiovascular disease (CVD) worldwide. While the prevalence of HTN increases with age, the biological mechanisms underlying it...
Abstract 4360339: When Drainage Backfires: Pericardial Decompression Syndrome in an ESRD Patient
Introduction: End stage renal disease (ESRD) patients may develop pericardial effusion due to fluid overload from inadequate dialysis. Large effusions, when drained, can cause peri...
Abstract 4369574: A Polypill Strategy for Lipid Lowering and Anti-Platelet Therapy After Acute Coronary Syndrome: A Pilot Randomized Controlled Trial
Background: Medication non-adherence following acute coronary syndrome (ACS) is a critical implementation gap in socioeconomically disadvantaged patients. The SECURE trial demonstr...
Abstract 4369500: MicroRNA-1’s Biophysical Function is essential for Postnatal Cardiac Maturation
Background: MicroRNA-1 (miR1) plays a critical role in maintaining cardiac homeostasis. Full knockout of miR1 results in postnatal lethality. While prior studies have primarily foc...
Abstract 4339911: Trends in Mortality of Ischemic Heart Disease and Cardiac Arrhythmias in the Adult Population: CDC Data Analysis (1999–2020)
Background: Ischemic heart disease (IHD) is the leading cause of Sudden Cardiac Death (SCD), primarily due to cardiac arrhythmias. An estimated 180,000–450,000 SCDs occur annually...
Abstract Sat706: Effectiveness of Bag-Mask Ventilation in Pediatric Out-of-Hospital CPR
Background: Pediatric out-of-hospital cardiac arrests (OHCA) have high morbidity and mortality. More than 5000 children have a nontraumatic OHCA annually in the United States and s...
Abstract 4346738: Genome-wide vQTL Analysis of Blood Lipid Traits
Background: Blood lipid levels are among the leading causal risk factors for cardiovascular disease. While genome-wide association studies (GWAS) have identified numerous loci asso...
Abstract 4367923: Aorta to Ilio-femoral Bypass During Total Arch Replacement with Frozen Elephant Trunk Facilitates Second-Stage Thoracoabdominal Aortic Repair with Normothermic Iliac Perfusion
Background: Thoracoabdominal aortic repair (TAAR) is a complex, high-risk procedure frequently performed as a second-stage operation in patients with connective tissue disorders, e...
Abstract 4367268: Regulatory LncRNA H19 and mitophagy in hypoplastic left heart syndrome and in immature ischemic/reperfused rodent hearts
Introduction: Hypoplastic left heart syndrome (HLHS) is one of the most clinically challenging congenital heart diseases. The long non-coding RNA (lncRNA) H19 has been identified a...
Abstract 4370131: Ghost Catheter Fibrin Sheath Presenting with Septic Pulmonary Emboli
Background: Ghost fibrin catheter sheath (GFCS) is a connective tissue sleeve that forms around a central venous catheter and may remain after removing it, mimicking its path. This...
Abstract 4365508: Outcomes of Heart Failure Hospitalizations in Urban Teaching vs. Non-teaching Hospitals: A Nationwide Propensity Score Matched Analysis in the United States
Background: Heart failure (HF) continues to be a major cause of morbidity and mortality worldwide, placing a significant burden on healthcare systems. Differences in the outcomes o...
Abstract 4366901: The Valve That Wasn't: Unraveling a Diagnostic Mystery
Background: Dynamic left ventricular outflow tract (LVOT) obstruction can clinically and echocardiographically mimic aortic stenosis (AS). We report an elderly patient with presume...
Abstract 4364158: A Ticking Time Bomb, Acute Amiodarone-Induced Pulmonary Toxicity Leading to ARDS in a Nonagenarian: A Case Report
Amiodarone is an iodine-containing antiarrhythmic agent commonly used to manage ventricular and supraventricular arrhythmias. Despite its clinical efficacy, amiodarone has a well-documented side effec...
Abstract 4369685: Multi-Task Deep Learning for Noninvasive Rapid BNP and NT-proBNP Estimation and Classification
Background: Natriuretic peptides such as BNP and NT-proBNP remain cornerstone biomarkers for diagnosing and management of heart failure (HF). However, their measurement is done mai...
Abstract 4362966: Patient-specific IPSC-derived Cardiomyocyte Phenotypes Reflect Clinical Variation Within a Family With FLNC Cardiomyopathy
Background: Truncating variants (TVs) in the filamin C gene ( FLNC ) have been associated with familial cardiomyopathies. However, phenotype...
Abstract 4365838: Survodutide for the Treatment of Obesity: Baseline characteristics of the SYNCHRONIZE Cardiovascular Outcomes Trial
Background: Dual agonism of glucagon and glucagon-like peptide-1 (GLP-1) receptors is effective in reducing body weight and fat mass, but its cardiovascular (CV) effects are unknow...
Abstract 4365970: Geospatial Mapping Reveals Racially Patterned Cardiometabolic Risk in Chicago Pharmacy Deserts
Introduction: Pharmacy deserts, areas where residents lack nearby access to pharmacies, are a structural barrier to healthcare. Prior work has documented racial disparities in phar...
Abstract 4358901: Circulating extracellular vesicle-derived CAPG as a novel molecule associated with pathophysiology and outcomes in heart failure
Introduction: Extracellular vesicles (EVs) facilitate the transportation of active biomolecules, including proteins, and play crucial roles in intercellular and interorgan communic...
Abstract 4360351: TGM2-Dependent Histone Serotonylation Is a Novel Cardioprotective Epigenetic Mechanism in HFpEF Pathogenesis
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, and its pathophysiology is not fully understood. Histone serotonylation has recent...
Abstract 4370568: Beyond Understanding: Trust and Clinician Engagement Drive Willingness to Participate in Research
Background: Despite national efforts to diversify clinical trial populations, participation remains low, particularly among historically underrepresented groups. While educational...