Circulation
Articles in this Issue
Abstract 4339097: Circadian Troponin Dynamics Reveal Sex-Specific Signals for Acute Coronary Syndrome Management
Introduction: The circadian variation of high-sensitivity cardiac troponin has been established, but whether sex-based differences in these rhythms affect early acute coronary synd...
Abstract 4360074: NFATC1 Regulates NKX2-5–Dependent Transcription and Chromatin States in Atrial Cardiomyocytes
Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with significant morbidity and mortality, yet its molecular mechanisms remain incompletely understood. We identified...
Abstract 4366703: Development of a Machine Learning-Based Prediction Model for Health-Related Quality of Life in Patients with Coronary Artery Disease
Background: Coronary artery disease (CAD) is the leading cause of mortality globally. As a chronic condition, CAD requires long-term management, and evaluating patients’ health-rel...
Abstract 4371189: Wrong Turn: Isolated Right-Sided Aortic Arch in the setting of non-ST Elevation Myocardial Infarction
Background: An isolated right-sided aortic arch is a very rare vascular anomaly that usually goes undiagnosed unless symptomatic at birth or during imaging during hospitalization....
Abstract 4364163: Polygenic Risk Score for Abdominal Aortic Aneurysm in Patients with Cardiometabolic Disease: Analysis of 40,000 Patients from 3 TIMI Trials
Background: Abdominal aortic aneurysm (AAA) is a common and potentially fatal condition when rupture occurs. Current US guidelines recommend screening by ultrasound in men aged 65–...
Abstract 4358615: Association of Framingham 10-year Cardiovascular Disease Risk Scores with Incident Probable Dementia and Cognitive Impairment in the SPRINT trial
Background: Cardiovascular disease (CVD) and cognitive impairment share several risk factors, which may explain the link between higher 10-year Framingham CVD risk score (FRS) and...
Abstract 4368019: High Visit-to-Visit Systolic Blood Pressure Variability Predicts Adverse Outcomes in Kidney Transplant Recipients: A Nationwide Cohort Study
Background&Objective: Visit-to-visit blood pressure variability (VVBPV) has emerged as an independent predictor of cardiovascular and renal outcomes, but its prognostic signifi...
Abstract 4364269: SSC5D Exacerbates Post-Myocardial Infarction Cardiac Dysfunction via p38/MAPK-Mediated Inflammatory Activation
Background: Myocardial infarction (MI) elicits a robust inflammatory response that is essential for myocardial repair but can also lead to adverse remodeling when excessive. Scaven...
Abstract 4357847: Takayasu arteritis presenting as hemorrhagic cerebrovascular accident
Description: A 24-year-old female presented to the emergency department with acute onset of right-sided hemiparesis accompanied by right facial drooping. Neurological examination r...
Abstract 4370675: Healthcare Costs following Lamotrigine, an Antiepileptic Agent with a Potential Ventricular Conduction Delaying Profile
Objective: While prior studies have examined the clinical risk of arrhythmias associated with lamotrigine (LTG), potentially due to a delay in cardiac conduction, it remains unknow...
Abstract 4370550: Device-Related Thrombosis on Watchman Implant: A Case Study Highlighting the Importance of Hypercoagulable Workup
68-year-old female with history of non-valvular atrial fibrillation who was unable to tolerate anti-coagulation due to multiple episodes of GI bleeds. She underwent left atrial appendage occlusion wit...
Abstract 4370336: Traumatic Ventricular Septal Defect Following Blunt Chest Trauma: A Rare but Life-Threatening Diagnosis
Description of Case: A 33-year-old previously healthy male presented with profound shock following a motor vehicle accident. Initial trauma workup revealed a sternal fracture and a...
Abstract 4364623: Development of a Multi-Agent System for Cardiovascular Diagnostic
This paper presents a multi-agent AI system designed to provide accurate diagnostic and personalized treatment recommendations for heart attack, heart failure, cardiac arrhythmia, coronary artery dise...
Abstract 4363481: Prognostic value of Markis classification in patients with coronary ectasia after an acute coronary syndrome: a single-center retrospective cohort study
Introduction: Coronary ectasia (CE) is defined as a diffuse dilatation of the coronary arteries, in which the diameter is ≥50% greater than that of the adjacent segment. In a conse...
Abstract 4359354: Impact of Mavacamten and Disopyramide on Left Ventricular Mechanical Dispersion and Ventricular Arrhythmia in Obstructive Hypertrophic Cardiomyopath
Background: Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by left ventricular (LV) hypertrophy and outflow tract (LVOT) obstruction, increasing the risk of life-t...
Abstract 4368270: Primary Cardiac Synovial Sarcoma arising from the Right Ventricle
Introduction: Primary cardiac synovial sarcoma (PCSS) is an extremely rare cardiac tumor, representing less than 1% of all primary cardiac tumors and approximately 5% of cardiac sa...
Abstract 4368255: Postoperative Atrial Fibrillation or Flutter Following Mitral Valve Surgery for Primary Mitral Regurgitation
Background: New-onset postoperative atrial fibrillation or flutter (POAF) is a known complication following mitral valve surgery in patients with mitral valve prolapse (MVP) and mi...
Abstract 4366689: Sex Disparities in Cardiac Rehabilitation: Referral, Enrollment, and Completion among STEMI Patients
Cardiac rehabilitation (CR) is recommended for ST-elevation myocardial infarction (STEMI) patients, yet is commonly underutilized. Past research suggests that disparities exist in CR referrals and par...
Abstract 4360052: Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress
Background: Cardiovascular disease and cancer are the two leading causes of morbidity and mortality worldwide. Metabolic dysregulation of cancer cells extends beyond the tumor micr...
Abstract Sun504: Early Novel Biomarkers Associated with Neurological Outcome in Out-of-Hospital Cardiac Arrest
Introduction: After out-of-hospital cardiac arrest (OHCA) with return of spontaneous circulation (ROSC), hypoxic-ischemic brain injury is the leading cause of severe disability and...
Abstract 4371102: Trends and In-Hospital Outcomes of Mechanical Circulatory Support in Heart Failure–Related Cardiogenic Shock: Insights from National Inpatient Sample (2016–2022)
Background: Cardiogenic shock (CS) remains a life-threatening complication in heart failure (HF), often requiring rapid hemodynamic support. Mechanical circulatory support (MCS) de...
Abstract 4365496: AI image analysis to aid echocardiographic surveillance in patients with breast cancer receiving cardiotoxic chemotherapies: A pilot proof-of-concept study
Background: Echocardiography (TTE) is used for cardiac surveillance in patients with breast cancer (BC) receiving potentially cardiotoxic therapies. There is significant variabilit...
Abstract 4372912: Advances in Imaging for Early Detection of Subclinical Atherosclerosis: A Systematic Review
Background: Early identification of subclinical atherosclerosis permits timely preventive intervention to reduce cardiovascular events. Although carotid intima-media thickness (CIM...
Abstract 4365553: Death-Associated Malfunctions in Boston Scientific ICDs: Insights from Postmarket Device Event Reports (2022–2024)
Background: Implantable cardioverter-defibrillators (ICDs) reduce mortality in patients at risk for sudden cardiac death, but postmarket surveillance is essential for detecting rar...
Abstract Sat205: Association of Cardiopulmonary Resuscitation Strategies with Diffuse Optical Measurements of Cerebral Hemodynamics
Introduction: Hemodynamic-directed cardiopulmonary resuscitation (HD-CPR) targets blood pressure (BP) goals during resuscitation and has shown improved outcomes compared to convent...