Circulation
Articles in this Issue
Abstract 4359480: GLP-1 Agonist Therapy Attenuates Circulating Gut-Derived Trimethylamine N-Oxide (TMAO) and Improves Cardiac Function and Exercise Performance in Cardiometabolic HFpEF
Background: Heart failure with preserved ejection fraction (HFpEF) poses a significant global health burden, characterized by poorly understood and heterogeneous underlying mechani...
Abstract 4367769: Successful Mapping and Ablation of Incessant Ventricular Fibrillation on Mechanical Circulatory Support.
Background/Introduction: Ventricular fibrillation (VF) storm represents a life-threatening emergency with high mortality. When VF becomes incessant and refractory to antiarrhythmic...
Abstract 4372998: Mitral Mystery: A Rare Case of Nonbacterial Thrombotic Endocarditis in the Setting of Factor V Leiden
Background: Intracardiac masses present a diagnostic challenge with a broad differential that includes thrombus, tumor, and vegetation. Accurate identification is critical as manag...
Abstract 4371983: Gonococcal Endocarditis of the Native Aortic Valve: A Rare but Aggressive Cause of Valvular Destruction
Introduction: Gonococcal infective endocarditis (IE) is a rare but aggressive complication of disseminated gonococcal infection (DGI), occurring in only 1–2% of DGI cases. While DG...
Abstract 4368778: Risk factors and outcomes of postoperative atrial fibrillation in patients with congenital heart defects
Introduction: Due to significant medical advances, most patients with congenital heart disease (CHD) reach adulthood, shifting CHD from a predominantly pediatric condition to a lif...
Abstract 4370730: Increased Evidence-Based Cardiovascular Post-Stroke Diagnostic Evaluation, Identification of Stroke Etiology and Cardiology and Neurology Collaboration: Durable Impact of the American Heart Association’s Getting to the Heart of Stroke <sup>TM</sup> Initiative
Background: Nearly one million individuals in the U.S. experience acute ischemic stroke (AIS) annually and one-year recurrent stroke risk may exceed 10%. American Heart Association...
Abstract 4367814: Trends And Disparities in Atrial Fibrillation and Sleep Disorders-Related Mortality in the United States: A CDC WONDER Database Analysis
Background: Sleep disorders are associated with an increased risk of atrial fibrillation (AF) due to shared risk factors. Despite this association, the sociodemographic mortality t...
Abstract 4369130: Cardiac Sympathetic Denervation, Catheter and Surgical Hybrid Ablation Successfully Treat Refractory Ventricular Arrhythmias – a Comprehensive Heart Team Approach
Background: Although percutaneous ablation is currently the mainstay of ventricular arrhythmia (VA) management, surgical cardiac sympathetic denervation (CSD) as well as surgical e...
Abstract 4370727: Online Cognitive Behavioral Therapy for Depressive Symptoms in Rural Patients with Cardiac Disease: Impact on Hospitalizations and Mortality
Introduction: Rural areas experience marked disparities in cardiac and mental health, and in access to healthcare, with higher levels of cardiac disease and depression than urban a...
Abstract 4338157: Nicotinamide Riboside is Protective in a Mouse Model of Heart Failure with Reduced Ejection Fraction
Nicotinamide adenine dinucleotide (NAD + ) is essential for cellular functions due to its roles as a redox cofactor or substrate for many enzymes. Intriguingly,...
Abstract 4361086: GLP-1 Receptor Agonists and Clinical Outcomes in Non-Diabetic Patients with Peripartum Cardiomyopathy: A Propensity-Matched Retrospective Cohort Study
Background: Peripartum cardiomyopathy (PPCM) is a potentially fatal form of heart failure with no established targeted therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs...
Abstract 4364887: Postoperative vocal cord paralysis in pediatric patients undergoing pulmonary artery reconstruction or unifocalization
Introduction: Children undergoing pulmonary artery reconstruction (PAR) surgery for multilevel PA stenosis or pulmonary atresia and major aortopulmonary collaterals (MAPCAs) are at...
Abstract 4369847: Trends in Substance Use-Related Mortality Among Adults With Heart Failure in the United States from 1999 to 2020: A CDC WONDER Analysis
Introduction: Substance use (SU) contributes to adverse cardiovascular outcomes, including myocardial toxicity, arrhythmia, and hemodynamic stress, which can lead to the developmen...
Abstract 4370302: Causes and Predictors of Mortality in Adults with Congenital Heart Disease: A Single Center Study
Backround: Advances in surgical and medical care of children born with congenital heart disease (CHD) has improved survival into adulthood. However, cardiac and non-cardiac morbidi...
Abstract 4362734: Racial and Ethnic disparities in heart transplantation and in-hospital mortality in patients admitted with end-stage heart failure (ESHF) in 2021: A Nationwide Analysis
Background: Heart transplant is considered the gold standard for the management of end-stage heart failure. Black patients have historically been known to have a higher mortality r...
Abstract 4364208: Sweet Taste Receptors Alter Contractility and Calcium Handling in Cardiomyocytes
GPCR-based taste receptors are expressed in taste buds where they mediate perception of bitter, umami, and sweet taste qualities. Bitterness is recognized by type II taste GPCRs (TAS2R), while umami a...
Abstract 4343268: ALOX15 mediates thrombin-induced myristoylation, trafficking and interaction of PARs leading to platelet activation and hemostasis
Background: Platelets express 12-lipoxygenase (ALOX12) and 12/15-lipoxygenase (ALOX15) which exhibit positional specificity in the oxygenation of polyunsaturated fatty acids such a...
Abstract Or115: Time to Bystander CPR and Survival Outcomes in Pediatric Out-of-Hospital Cardiac Arrest
Background: Bystander cardiopulmonary resuscitation (CPR) is a key link in the chain of survival for out-of-hospital cardiac arrest (OHCA). In adults, bystander CPR administered at...
Abstract 4366400: Malnutrition Attenuates the Protective Obesity Paradox in Atherosclerotic Cardiovascular Disease
Background: Obesity is associated with lower mortality in individuals with established ASCVD, a phenomenon known as the obesity paradox. Malnutrition is a robust and consistent pre...
Abstract 4369367: MDA-LDL levels and Histological Investigation of IVUS and Thrombus Aspiration Tissue in Patients undergoing Emergency Percutaneous Coronary Angioplasty for ACS
Background: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is believed to play a critical role in plaque destabilization. However, there is limited evidence regarding t...
Abstract 4357602: Vascular characteristics of idiopathic myocardial fibrosis in non-ischemic sudden cardiac death.
Background: Vascular remodeling, both neovascularization and lymphangiogenesis, associated with myocardial fibrosis following ischemic injury is well recognized. The presence of va...
Abstract 4366162: Electrical Stimulation Enhances Contractile Performance of Tissue-Engineered Pulsatile Conduits with hiPSC-Derived Cardiomyocytes
Single ventricle congenital heart defects (SVCHDs) are characterized by the presence of only one functional ventricular chamber. The Fontan procedure, a common palliative intervention, reroutes venous...
Abstract 4343116: Metagenomic Profiling of Gut Microbiome Among the Risk Groups of Atherosclerotic Coronary Artery Disease
Introduction: Several studies have shown that alterations of gut microbiome are associated with various diseases, such as atherosclerosis. Published literature often compared the g...
Abstract 4363438: My Heart Will Go On: A Rare Case of Massive Candida Auris Pericardial Effusion
A 40-year-old male with past medical history of Methicillin-resistant staphylococcus aureus endocarditis treated with open valve replacement of tricuspid valve and resection of aortic valve vegetation...
Abstract 4369582: Ablation for Atrial Fibrillation: A Comprehensive Meta-Analysis of Randomized Controlled Trials with Reconstructed Time-to-Event Data
Introduction: Catheter ablation is widely used for rhythm control in atrial fibrillation (AF), yet outcomes vary across trials and patient populations. No prior study has combined...