Circulation
Articles in this Issue
Abstract 4346601: Influence of Religiosity on Symptoms and the Quality of end-of-life Cardiovascular Disease Patients
Introduction: Religiosity is a core component of palliative care and whose roles in patients with cancer were described. However, there is a paucity of studies in cardiovascular di...
Abstract 4360523: Lifetime Earnings in Pediatric Cardiology: A Net Present Value Analysis of Academic and Private Practice Pathways
Introduction: Pediatric cardiology requires extensive training, yet the long-term financial implications across academic subspecialties and private practice remain poorly character...
Abstract 4366576: Treatment Implications of LDL-Cholesterol and Apolipoprotein B Discordance: Insights from the Very Large Database of Lipids (VLDbL) and the National Health and Examination Survey (NHANES)
Background: ApoB-containing lipoproteins, including LDL, are well-established causes of atherosclerotic cardiovascular disease (ASCVD). While typically highly correlated, apoB and...
Abstract 4343849: Assessment of Lipid-Lowering Therapy and Atherosclerotic Cardiovascular Disease Outcomes in Patients with Familial Hypercholesterolemia: Insights from the NIH <i>All Of Us</i> Dataset
Introduction: Familial hypercholesterolemia (FH) is a genetic disorder affecting 4 in 1000 people, resulting in lifelong elevated low-density lipoprotein cholesterol (LDL) and incr...
Abstract 4366298: ECMO Combined with Thrombectomy Yields Superior Outcomes in Acute High-Risk Pulmonary Embolism
Background: Extracorporeal membrane oxygenation (ECMO) is used as a rescue therapy in patients with severe high-risk pulmonary embolism (PE), but data on optimal management and esp...
Abstract 4368055: Postprandial Hypotension and Blood Pressure Variability in Type 2 Diabetes
Background: Postprandial hypotension (PPH) is a frequent but under-recognized hemodynamic disturbance in patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate...
Abstract 4339562: High-output Heart Failure in Acute Respiratory Distress Syndrome: A Secondary Analysis of the FACTT Trial
Introduction: Acute respiratory distress syndrome (ARDS) is characterized by pulmonary edema, hypoxia and systemic inflammation. The presence and clinical implications of a high ca...
Abstract 4364292: The Overlap of Atrial Fibrillation and Sudden Cardiac Death Unmasking the Hidden Role of Hypertrophic Cardiomyopathy in the US Population From 1999 to 2020
Introduction: Hypertrophic cardiomyopathy with atrial fibrillation and sudden cardiac death represents a high-risk triad. Despite advances in care, national trends in HCM-related a...
Abstract 4369277: Risk of Arrhythmia Persists Throughout Acute and Chronic Phases of Autonomic Dysreflexia following Spinal Cord Injury: A Rodent Model Study
Autonomic Dysreflexia (AD) is a potentially life-threatening overreaction of the sympathetic nervous system that commonly occurs in individuals with spinal cord injuries at or above the T6 level. This...
Abstract 4365118: Advanced Complementary Imaging Analysis of Single Ventricle Patients Using Cardiac Magnetic Resonance and Echocardiography
Introduction: The hemodynamic efficiency in patients with single ventricle (SV)-type anatomy is critical for their long-term outcomes. Conventional and novel metrics of SV function...
Abstract 4338173: Chronic Stress and Mortality Among Adults with Abnormal Ankle-Brachial Index in Rural South Africa: A Longitudinal Analysis of the HAALSA Cohort
Background: Individuals with an abnormal ankle brachial index (ABI) are at risk for peripheral artery disease (PAD), a condition linked to elevated psychological stress and mortali...
Abstract 4369684: Mitochondrial DNA Copy Number (mtDNA-CN): Associations with Mortality and Gene Expression in the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Biorepository
Introduction: Higher mtDNA-CN reflects better mitochondrial function, while lower levels indicate mtDNA release and increased inflammation. Although mtDNA-CN serves as a marker of...
Abstract Or114: Return of spontaneous circulation immediately after defibrillation detected by continuous hands-free carotid Doppler
Background: The Advanced Life Support guidelines (AHA, ERC) emphasize immediate resumption of chest compressions for 2 minutes after defibrillation for ventricular fibrillation (VF...
Abstract 4366661: Low-Cost Promotional Coronary Artery Calcium Screening Identifies High-Risk Patients Missed by Traditional Referral Pathways in Urban Hospital
Background: Coronary artery calcium (CAC) scoring is a key tool for risk stratification in preventive cardiology. While clinician-referred patients are typically higher-risk, some...
Abstract 4371075: Exploring the Genetics of Dilated Cardiomyopathy: A Case Report of a Novel Nonsense Mutation in the Ryanodine Receptor 2 Gene Causing Arrhythmogenic Dilated Cardiomyopathy
Introduction: Genetic mutations are a well-known cause of dilated cardiomyopathy (DCM), occurring in approximately 30% of the cases. Mutations in the ryanodine receptor 2 (RYR2) ge...
Abstract 4370123: Left Bundle Branch Area Pacing versus Biventricular Pacing in Cardiac Resynchronization Therapy: An Updated Systematic Review and Meta-Analysis
Background: Left bundle branch area pacing (LBB-P) has emerged as a physiologically targeted alternative to biventricular pacing (BiV-P) for cardiac resynchronization therapy (CRT)...
Abstract 4366664: Impact of the Lipid-Lowering Therapy on the Distribution Differences Between Lipid Fractions
Background: Diagnosis of hypercholesterolemia relies on laboratory assessment of lipid parameters. This study aimed to evaluate differences in the distribution of low-density lipop...
Abstract 4373391: Risk of Ischemic Stroke, Major Bleeding, Cardiovascular and All-cause Mortality in Patients with Atrial Fibrillation, Comparing Anticoagulation Therapy vs Left Atrial Appendage Closure: Meta-Analysis of Randomized Controlled Trials
Introduction: Clinical trials comparing anticoagulation (AC) therapy with left atrial appendage closure (LAAC) in patients with atrial fibrillation (AF) have shown conflicting resu...
Abstract 4369803: Adverse Clinical Events Due to the Safety Mode in Implantable Defibrillators
Introduction/Background: The Safety Mode (SM) in Boston Scientific pacemakers provides back-up pacing if a critical device malfunction or unexpected internal error occurs. However,...
Abstract 4343939: COVID-19 Vaccine-Induced Cardiac Inflammation: A Review of 103 Cases and Appraisal of VAERS Database
Introduction/Background: The COVID-19 vaccines has been pivotal in controlling SARS-CoV-2 transmission and reducing hospitalization and mortality. Authorized vaccines, including mR...
Abstract 4373475: Outpacing Tradition: Conduction System Pacing Demonstrates Superior Outcomes to Biventricular Pacing for HFrEF.
Background: Cardiac resynchronization therapy (CRT) improves outcomes in heart failure patients with reduced ejection fraction (HFrEF) and ventricular dyssynchrony. While biventric...
Abstract Sun904: Variability of Automated External Defibrillator Signage Across Six Continents
Introduction/Background: Despite evidence supporting their efficacy in improving out-of-hospital cardiac arrest survival, public utilization of automated external defibrillators (A...
Abstract 4368912: Sex Based Differences In In-hospital Mortality Among Patients With AMI-Related Cardiogenic Shock And HF-Related Cardiogenic Shock
Background: Sex-based disparities in cardiogenic shock (CS) remain underexplored, particularly when stratified by etiology—Acute Myocardial Infarction (AMI) versus Heart Failure (H...
Abstract 4361481: Catheter Ablation for Ventricular Tachycardia in Ischemic Cardiomyopathy: A Meta-Analysis with Reconstructed Time-to-Event and Trial Sequential Analysis
Background: Ventricular tachycardia (VT) is a major contributor to death among ischemic heart disease (IHD) patients. In this systematic review and meta-analysis, we evaluate the e...
Abstract 4367317: Leveraging De Novo UK Biobank GWAS to Identify Novel Genetic Loci at the Intersection of Atrial Fibrillation and Cancer
Background: Atrial fibrillation (AF) is a well-established complication of cancer and its treatment. However, the reverse association—cancer arising in individuals with AF—remains...