Circulation
Articles in this Issue
Abstract 4346108: CKD and Acute Myocardial Infarction-related mortality among US adults over the age of 65: Insights from CDC WONDER (1999–2020)
Background: This study investigates trends in acute MI-related mortality in adults aged 65 and older with CKD, focusing on overall, geographic, and racial disparities from 1999 to...
Abstract 4363934: Trends in the Incidence, Prevalence, and Outcomes of Heart Failure for Medicare Beneficiaries: A Retrospective Cohort Study
Background: The prevalence of heart failure (HF) is expected to increase with the aging of the U.S. population. A national evaluation of the epidemiology of HF among Medicare benef...
Abstract 4357221: Monocyte to Lymphocytes Ratio as a Superior Predictor of Major Cardiovascular Events compared to hs-CRP in Patients with Angina and Nonobstructive Coronary Artery Disease
Background: An increasing recognition of angina and nonobstructive coronary artery disease (ANOCA) underscores the importance of this patient group. While inflammation is a well-es...
Abstract 4345594: Emergence and Applications of FDA-Cleared Artificial Intelligence in Cardiovascular Care
Introduction: Artificial Intelligence and machine learning (AI/ML) technologies are rapidly expanding in the field of medicine, as well as cardiology. Studies within cardiovascular...
Abstract 4365790: Therapeutic Gaps in Lipid Management Among Patients with Prior ASCVD Hospitalized with Acute Myocardial Infarction: Insights from the NCDR Chest Pain-MI Registry
Background: Lipid-lowering therapy (LLT) is essential for secondary prevention in patients with atherosclerotic cardiovascular disease (ASCVD). However, real-world data on LLT use,...
Abstract 4362745: Uncontrolled hypertension is associated with high healthcare resource utilization: Observations from the EnligHTN study
Background: Despite the availability of various treatment options, uncontrolled hypertension (HTN) remains prevalent, significantly increasing risks of cardiorenal disease and mort...
Abstract 4368661: <u>Increased SIRT1 Expression in Internal Mammary Artery Vascular Smooth Muscle Cells Prevents Pro-Inflammatory Phenotype</u>
Background: Atherosclerosis (AS) is a chronic inflammatory disease that predominantly affects the coronary vascular bed, while sparing select vascular territories such as the inter...
Abstract 4359588: AI-Augmented Interpretation of Coronary CT Angiography Reports: A Large Language Model-Based Framework
Introduction: Coronary CT angiography (CCTA) is a valuable clinical tool for evaluation of coronary artery disease. However, the standardized framework, Coronary Artery Disease Rep...
Abstract 4364674: Black Impact: A Community Based Lifestyle Intervention to Improve Cardiovascular Health and Psychosocial Stress in Black Men.
Background: Cardiovascular disease (CVD) is the leading cause of death in Black men, contributing to the shortest life expectancy among U.S. race/sex groups. Black men have the low...
Abstract 4360915: Association Between Direct Oral Anticoagulant Dose and Risk of Stroke/Systemic Embolism, Major Bleeding, or All-Cause Mortality in Patients with Ischemic Stroke and Atrial Fibrillation
Background: Direct oral anticoagulants (DOACs) are recommended for stroke prevention in patients with atrial fibrillation (AF); however, inappropriate dosages may increase risk for...
Abstract 4367492: Shared Circulating Proteins of Heart Failure and Dementia Risk: The Atherosclerosis Risk in Communities (ARIC) Study
Introduction: Heart failure (HF) and dementia have overlapping risk factors and bidirectional epidemiologic associations, suggesting shared biological pathways. Limited data exist...
Abstract 4371026: Rural–Urban Disparities in Cardiac Disease Outcomes: An EHR-Based Cohort Study in Missouri
Background: Cardiovascular disease remains the leading cause of death in the U.S., and rural residents have more difficult access to the same medical care that urban residents have...
Abstract 4365167: Dampening inflammation by disrupting PDE4B attenuates coronary atherogenesis preventing heart failure
Background: Despite historical success of launching cholesterol-lowering drugs, coronary atherosclerotic disease (CAD) remains a leading cause of mortality and morbidity worldwide....
Abstract 4370706: Calsarcin-1 modulates the muscle LIM protein/Z-disc complex in familial hypertrophic cardiomyopathy
Introduction: Hypertrophic cardiomyopathy (HCM) is a hereditary disorder of cardiac muscle and is typically caused by mutations in genes encoding sarcomere proteins. Despite calsar...
Abstract 4370019: Does Obesity Paradox Influence Outcomes Following Percutaneous Left Atrial Appendage Occlusion? A Propensity-Score Matched Analysis of the TriNetX Global Collaborative Network Database
Background: Percutaneous left atrial appendage occlusion (LAAO) has demonstrated promising results in reducing the risk of stroke in patients with atrial fibrillation who are not c...
Abstract 4373224: Improving the Content Validity for the Kansas City Cardiomyopathy Questionnaire in Hypertrophic Cardiomyopathy
Background: Given the importance of understanding the impact of treatment on patients’ symptoms, function, and quality of life, the Kansas City Cardiomyopathy Questionnaire (KCCQ)...
Abstract 4365095: Not So Relaxin: Preeclampsia Risk After Frozen Embryo Transfer with Absent Corpus Luteum
Introduction: Assisted reproductive technologies have become increasingly common and have been associated with a higher risk of preeclampsia. Data suggests that programmed (medicat...
Abstract 4369739: Refining Prediction of Cerebrovascular Events in ATTR-CM with Sinus Rhythm to Guide Preventive Anticoagulation
Background: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) face a significant risk of cerebrovascular events, even when in sinus rhythm (SR). However, no validated to...
Abstract 4362440: Effectiveness of chest pain center accreditation on the hospital outcome of acute aortic dissection: a nationwide study in China
Background: The National Chest Pain Center Program (NCPCP) is a nationwide, quality enhancement program aimed at raising the standard of care for patients experiencing acute chest...
Abstract 4368766: Timing of Onset of Peripartum Cardiomyopathy: Risk Factors and Clinical Outcomes
Background: Peripartum cardiomyopathy (PPCM) is a rare but serious form of heart failure in young women, defined by new-onset LVEF <45% near the end of pregnancy or postpartum....
Abstract 4362957: TT-10–loaded Nanoparticles Promote Cardiomyocyte Proliferation and Improve Recovery from Myocardial Injury in Pig
Background: Adult mammalian cardiomyocytes (CMs) exhibit limited regenerative capacity after myocardial infarction (MI). Yes-associated protein (YAP) has been shown to stimulate CM...
Abstract 4365801: Finerenone Reduces Sudden Death across the Spectrum of Cardio-Kidney-Metabolism: the FINE-HEART Pooled Analysis
Background: Mineralocorticoid receptor antagonists (MRAs) mechanistically may alter pathways of cardiac fibrosis and electrical stability. The non-steroidal MRA finerenone has been...
Abstract 4369371: Endocardial to epicardial blood flow ratio predicts the placebo-controlled efficacy of the coronary sinus reducer
Background: The coronary sinus reducer (CSR) has placebo-controlled evidence of angina benefit from two randomised placebo-controlled trials. The characteristics of patients with m...
Abstract 4370972: Impact of Aortic Annular Area on Outcomes Following Balloon-Expandable vs. Self-Expandable Valve-in-Valve Transcatheter Aortic Valve Replacement
Background: Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) is an increasingly preferred strategy for managing failed surgical bioprosthetic valves, especially in...
Abstract Sat708: Pediatric Airway Opening Index: Novel Description and Association with Cardiac Arrest Physiology and Outcomes
Introduction: Pediatric cardiopulmonary resuscitation (CPR) guidelines provide primitive ventilation guidance (observe chest rise, target a ventilation rate). Calculated from capno...