Circulation
Articles in this Issue
Abstract 4363344: Very High-Risk Coronary Artery Calcium Score Without Excess Epicardial Fat Volume might not be Associated with Significant Obstructive Coronary Artery Disease
Background: Calcium score has been recommended to be utilized in addition to ACC/AHA risk score for optimizing risk category if needed particularly in the intermediate risk group....
Abstract 4367551: Delayed Post-Infarction Ventricular Septal Defect: A Case Report Highlighting Diagnostic Challenges and Choice of Surgical Management
Background: Post-Myocardial Infarction Ventricular Septal Defect (PIVSD) is a rare and life-threatening mechanical complication following acute myocardial infarction (MI). It prese...
Abstract 4366513: Therapeutic Precision vs. Cardiac Risk: A Meta-Analytic Review of Osimertinib in NSCLC
Introduction: Targeted therapies have revolutionized cancer treatment by focusing on specific oncogenic drivers. Osimertinib, a third-generation EGFR inhibitor, was developed to ov...
Abstract 4372358: The His651Arg Mutation in <i>β-Myosin</i> gene Causes Dilated Cardiomyopathy (DCM)
Background: Inherited dilated cardiomyopathy (DCM) is a structural heart disease characterized by pathological enlargement of the heart. DCM can be caused by a mutation in...
Abstract 4371820: Trends and Disparities in Maternal Hypertensive Disorders Among High-Income Nations from 1990–2021: A Benchmarking Global Analysis
Background: Maternal hypertensive disorders (MHD), a leading cause of maternal and perinatal morbidity and mortality, remain a critical public health issue even in high-income coun...
Abstract 4367905: Medicare utilization and reimbursement patterns of remote monitoring for hypertension across primary care, nephrology, and cardiology
Background: Remote physiologic monitoring (RPM) codes are increasingly being used to manage hypertension. Internists commonly perform hypertension monitoring and RPM-related billin...
Abstract 4365558: The Impact of an Investigational First-In-Class Fully Human Natriuretic Peptide Receptor 1-Blocking Monoclonal Antibody REGN7544 on Systolic Blood Pressure and Hypovolemic and Hypotensive Disorders in Mice
Introduction: Natriuretic peptide receptor 1 (NPR1) activation by atrial and brain natriuretic peptides (ANPs and BNPs) reduces BP through vasorelaxation and decreased intravascula...
Abstract 4360798: Sex-differences in associations of continuous glucose monitoring metrics with hypertension and elevated blood pressure among individuals without diabetes
Background: Prediabetes and diabetes are associated with increased risk for hypertension (HTN) and cardiovascular disease, especially in women. Relations of glycemic variability an...
Abstract 4368167: Intestinal Microbiota-derived Phenylacetic acid Accelerates Perivascular Adipose Tissue Senescence and Atherosclerosis in Aging
Background: The microbially produced phenylalanine–derived metabolite Phenylacetic acid (PAA) contributes to endothelial senescence in aging. However, the effects of PAA on perivas...
Abstract 4372525: Widening Income-Based Disparities in Cardiovascular Mortality Among Working-Age US Adults 1999-2023
Background: After decades of progress, cardiovascular (CV) mortality among younger US adults is rising, but little is known about how these patterns vary by income....
Abstract 4361141: Impact of Aortic Insufficiency Severity on ECPELLA-provided Hemodynamic Support and Left Ventricular Unloading: A Triadic In Vitro–In Vivo–In Silico Analysis
Introduction: The combination therapy of venoarterial extracorporeal membrane oxygenation (VA-ECMO) and transaortic valve micro-axial flow pump catheter (Impella), so-called ECPELL...
Abstract 4367478: Enhanced Safety and Efficacy of Watchman FLX Versus Watchman 2.5 in Percutaneous Left Atrial Appendage Occlusion: An Updated Comprehensive Meta-Analysis
Background: Percutaneous left atrial appendage occlusion (LAAO) offers stroke prevention for patients with non-valvular atrial fibrillation. While the Watchman 2.5 device has been...
Abstract 4361607: A RARE CARDIAC COMPLICATION OF LEGIONNAIRES' DISEASE: LEFT VENTRICULAR APICAL THROMBUS WITH SEVERE CARDIOMYOPATHY
Introduction: Legionnaires’ disease, caused by Legionella pneumophila, primarily manifests as severe pneumonia but can lead to rare cardiac complications. Left ventricular (LV) thr...
Abstract 4371690: Equalizing the Odds: Valve Surgery and Mortality in Infective Endocarditis Among IVDU and Non-IVDU Populations
Background: Infective endocarditis (IE) is a serious infection of the heart valves and endocardium with substantial morbidity and mortality. Intravenous drug use (IVDU) is a major...
Abstract 4364524: Echocardiographic Variables Associated with Postnatal Compromise and Mortality in Prenatally Diagnosed Tetralogy of Fallot with Absent Pulmonary Valve, a Fetal Heart Society Collaborative Study
Background: Tetralogy of Fallot with absent pulmonary valve (TOF/APV) is a rare congenital heart defect with a broad spectrum of outcomes. A multicenter study of prenatally diagnos...
Abstract 4369983: Outcomes of Heart Failure with Preserved Ejection Fraction in Pregnancy: A Propensity-Matched Analysis
Introduction: Heart failure with preserved ejection fraction (HFpEF) accounts for the majority of heart failure admissions in women; however, its impact during pregnancy is underex...
Abstract 4363281: Mitral Annular Calcification, Coronary Artery Calcification, and Risk of Incident Atrial Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: Atrial fibrillation (AF) is a prevalent arrhythmia associated with significant morbidity and mortality. Coronary artery calcification (CAC) and mitral annular calcifica...
Abstract 4366416: Polyvascular Disease Is Associated With Increased Platelet Activity, Hyperreactive Platelet Transcriptome and Cardiovascular Events
Background: Many patients with peripheral artery disease (PAD) have concomitant coronary artery disease (CAD). Patients with concomitant PAD and CAD, known as polyvascular disease,...
Abstract 4367553: Effectiveness of a Food Pharmacy Program on reducing systolic and diastolic blood pressure in a safety net clinic network
Introduction: Poor diet is a major contributor to hypertension incidence and poor control, contributing to 45% of cardiometabolic deaths. Black and African American communities fac...
Abstract 4367018: Impact of downtime on surgical outcomes of acute type-A aortic dissection presenting with cardiopulmonary arrest
Background: We analyzed patients with acute type-A aortic dissection (ATAAD) presenting with cardiopulmonary arrest (CPA) to establish whether the timing of operative treatment and...
Abstract 4343806: The features of return-to-work anxiety after implantable cardioverter-defibrillator implantation among the Japanese working population
Backgrounds: The patients with implantable cardioverter defibrillator (ICD) have been shown to be anxious, whereas the features of return-to-work anxiety after ICD implantation amo...
Abstract 4350932: Incomplete Adoption of 2022 American Heart Association Guidelines for Intravenous Iron in Heart Failure with Reduced Ejection Fraction with Iron Deficiency: A TriNetX-Based Retrospective Study
Background: On Apr. 1, 2022, the AHA/ACC/HFSA released guidelines recommending intravenous (IV) iron for patients with heart failure with reduced ejection fraction (HFrEF) and iron...
Abstract 4367913: The Highly Electronegative HDL Subfraction, H5, Promotes Cell Dysfunction via Ferroptosis
Background: Ferroptosis is a regulated, iron-dependent form of cell death characterized by the accumulation of lipid peroxides and oxidative stress. The process is closely linked t...
Abstract 4369174: Spatial Multi-omics Profiling of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and diastolic dysfunction. Coronary microvascular dysfunction (CMVD) occurs in most H...
Abstract 4370635: Machine Learning Approach for Ultrasound-Based Calf Muscle Blood Flow Analysis in Peripheral Arterial Disease Diagnosis
Introduction: The ankle-brachial index (ABI) is the most common method for detecting peripheral arterial disease (PAD), but its sensitivity is limited, especially in patients with...