Circulation
Articles in this Issue
Abstract 4366292: Heart Rate Variability Monitoring for Early Detection of Cardiovascular Morbidities in Black Postpartum Women
Maternal mortality is three times higher in Black women compared to non-Hispanic white women. The postpartum period, the time with the least amount of health surveillance, accounts for 65% of maternal...
Abstract 4344798: Transseptal Rescue for Failure to Cross the Aortic Valve During Valve-in-Valve TAVR
Introduction/Background: Retrograde aortic valve crossing is a fundamental step in transcatheter aortic valve replacement (TAVR). With the expansion of TAVR programs, rare but chal...
Abstract 4364786: Computed Tomography Cardiac Angiography Guided vs Invasive Angiography Alone in Patients with Prior Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis
Introduction: Patients with previous coronary artery bypass grafting (CABG) commonly need invasive coronary angiography (ICA). However, ICA in these patients is technically challen...
Abstract 4370467: Downregulation of CCR6 in severe coronary artery disease impairs marginal zone B cell mediated atheroprotective IgM production
Introduction: Oxidized low density lipoproteins (OxLDL) present in atherosclerotic plaques. Epidemiological studies demonstrate that IgM antibody against malondialdehyde LDL (MDA-L...
Abstract 4367973: Post–COVID-19 Pediatric Myocarditis Shows Higher Adjusted Mortality and Greater Response to IVIG With Steroids in Tertiary Care LMIC Setting
Introduction: Myocarditis is a rare but potentially life-threatening inflammatory condition of the myocardium, especially in children. Its spectrum ranges from mild symptoms to ful...
Abstract Sun1008: GATM Identified as a Potential Drug Target for Cardiac Arrest Through Multi-Omics Mendelian Randomization Integrating GWAS, eQTL, and pQTL Data
Background: Targeted therapy for cardiac arrest remains a significant clinical challenge. Multi-omics Mendelian randomization (MR) analysis provides a novel framework for identifyi...
Abstract 4369150: AI-enabled Plaque Phenotype Analysis of Coronary Computed Tomography Angiography Findings in Patients with Nonacute Chest Pain using FFR <sub>CT</sub> : Results from the PRECISE Trial
Introduction: Advances in coronary computed tomography angiography (CCTA) have enhanced the possibilities for assessment and quantification of coronary artery disease (CAD). Using...
Abstract 4363343: Papillary Muscle Anatomy in Hypertrophic Cardiomyopathy: Comparison to Normal and Impact on Outcomes of Septal Myectomy
Background: Several studies have described anteroapical displacement of the anterolateral papillary muscle (PM) in patients with hypertrophic cardiomyopathy (HCM), implying a role...
Abstract 4366602: Altered Left Ventricular Hemodynamic Forces in Transposition of Great Arteries Following Arterial Switch Operation
Introduction: As patients with d-looped transposition of the great arteries (d-TGA) reach adulthood following the arterial switch operation (ASO), clinical focus has shifted toward...
Abstract Sun801: A Porcine Model of Cardiac Arrest Without Pre-Arrest Fluid Loading, Sternal Molding, or Epinephrine
Introduction: A large fraction of investigators studying cardiac arrest use piston-based sternal compression CPR ( PBSC-CPR ). Many use one...
Abstract 4359840: A First-In-Human Phase 1 Study of the Safety, Tolerability, and Pharmacodynamics of REGN7544, a Novel Natriuretic Peptide Receptor 1–Blocking Monoclonal Antibody
Background: The cardiac hormones atrial natriuretic peptide and brain natriuretic peptide activate natriuretic peptide receptor 1 (NPR1), leading to the generation of cyclic guanos...
Abstract 4371009: Preexisting Inflammatory Disorders are Associated with Hypertensive Disorders of Pregnancy
Background: Hypertensive disorders of pregnancy (HDP) are characterized by dysregulated inflammatory responses at the cellular level and increased expression of pro-inflammatory cy...
Abstract 4363107: Hypertension Outcomes Following Cardiac Rehabilitation in a Safety-Net Population
Background: Cardiac rehabilitation (CR) is a proven intervention to reduce cardiovascular morbidity and mortality; however, its effect on blood pressure (BP) has not been studied i...
Abstract 4372137: Cardiometabolic Risk Factor Control in the Progression from Pre–Heart Failure to Clinical Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Pre–heart failure (pre-HF) is associated with a significantly increased risk of progression to clinical heart failure (HF). However, the independent and collective asso...
Abstract 4340246: Tackling Telemetry: A Resident Run Initiative to Reduce Unnecessary Telemetry Use
Background: Telemetry is a valuable tool for close clinical monitoring. However, when used in non-indicated settings, it contributes to alarm fatigue, increased healthcare costs, a...
Abstract 4371222: Electrocardiographically Subtle Inferior Myocardial Infarction: The Importance of Troponin, Clinical Context, and Artificial Intelligence
Case Description: Occlusion myocardial infarctions (OMI) can present with minimal ECG changes, making diagnosis challenging without high clinical suspicion. STEMI criteria have lim...
Abstract 4362827: Urine biomarkers predict declining kidney function and risk of cardiovascular disease
Introduction/Background: Urine biomarkers of kidney function may predict the progression of kidney dysfunction and risk of cardiovascular disease....
Abstract 4367563: Association Between Embolic Protection Device Use and Periprocedural Outcomes in Carotid Artery Stenting
Introduction: Carotid artery stenting (CAS) is increasingly used in carotid revascularization. While embolic protection devices (EPDs) are recommended during CAS to reduce the risk...
Abstract 4368721: Myocardial Inflammation and Complete Heart Block in Anti-NXP-2 Dermatomyositis: An Unrecognized Cardiac Manifestation
Introduction: Dermatomyositis (DM) is a rare autoimmune myopathy with multisystem involvement including skin and skeletal muscle. Cardiac conduction abnormalities are rarely report...
Abstract 4371065: Health-Related Priorities and Social Needs Among Socially Vulnerable Mothers at Risk for Cardiovascular Disease
Background: Cardiovascular disease (CVD) risk factors are highly prevalent and rising among women of reproductive age. Mothers of young children (ages 0–5) face unique barriers to...
Abstract 4371781: Long-term Prognostic Value of the Ratio of Red Blood Cell Distribution Width to Albumin in Patients With Acute Decompensated Heart Failure Patients
Backgrounds: Previous studies have shown that the ratio of red cell distribution width to serum albumin level (RAR) is an integrative and new inflammatory marker. RAR is associated...
Abstract 4365304: Prolonged QT Interval After Cryptogenic Stroke and Risk of Recurrent Stroke in the ARCADIA Trial
Introduction: Prolonged QT interval has been associated with first stroke of any type in the general population. Whether QT prolongation predicts recurrent stroke is unknown....
Abstract Sun1007: Profiling Gene Expression of the Hippocampus in a Rat Model of Ventricular Fibrillation Cardiac Arrest Resuscitated With eCPR and the Effects of Hypothermic Temperature Control
Introduction: The impact of global ischemia and reperfusion on the brain has been extensively studied in animal models of cardiac arrest (CA) and resuscitation. Although therapeuti...
Abstract 4364301: Beyond the Valve: Rethinking the Role of SGLT2 Inhibitors in Aortic Stenosis — A Systematic Review and Meta-Analysis of Mortality and Heart Failure Outcomes
Background: Aortic stenosis (AS) is the leading cause of valvular heart disease in the United States, affecting 5% of individuals over the age of 65. To date, there has been no med...
Abstract 4370474: Ischemia-Induced tRNA-Derived Small RNA Mitigates Cardiac Fibrosis via Enhancing Autophagic Flux
Heart failure (HF) is an increasingly prevalent cause of morbidity and mortality in the United States, with a projected prevalence of 8.7 million by 2030. Cardiac fibrosis, which develops following mo...