Circulation
Articles in this Issue
Abstract 4369230: Plasma Proteins Associated with the Immune Response to Anthracycline Cardiotoxicity in Patients with Hematologic Malignancies
Background: Anthracyclines such as doxorubicin (Dox) are well recognized to induce dose-dependent cardiotoxicity. However, traditional imaging and blood biomarkers of myocardial in...
Abstract 4367494: Procedural Outcomes of Transvenous Lead Extraction in Patients with Prior Sternotomy: Insights from a Large Volume US Center
Background: A history of prior sternotomy has been debated as either a protective factor or a risk for worse outcomes in patients undergoing transvenous lead extraction (TLE). The...
Abstract 4364733: Acceptability of Cardiovascular Prevention Strategies Among People With HIV: a Mixed-Methods Study
Background: People with HIV (PWH) have elevated cardiovascular risk, but acceptability of cardiovascular prevention strategies among PWH is unknown....
Abstract 4352481: Four-Dimensional Flow Magnetic Resonance Imaging-Derived Vortex Flow and Wall Shear Stress Predict Short-Term Aortic Expansion in Ulcer-Like Projections of Aortic Dissection
Background: Ulcer-like projections (ULPs) in aortic dissections are linked with aortic expansion, but predicting the progression is difficult. While earlier studies used computatio...
Abstract 4364592: Endovascular Intervention vs Surgical Bypass in Aorto-Iliac Disease
Background: Aortoiliac disease, a subset of peripheral artery disease (PAD), frequently necessitates revascularization. While surgical bypass has long been the standard of care, en...
Abstract 4366053: Impact of Functional Autoantibodies Against Endothelin-1 Receptor Type A and Angiotensin II Receptor Type 1 on Myocardial Dysfunction
Introduction: autoantibodies (AAs) activating endothelin-1 receptor type A (ETAR-AAs) and angiotensin II receptor type 1 (AT1R-AAs) are associated with microvascular obstruction, l...
Abstract 4366692: Left Atrial Lipomatous Metaplasia in Patients with Atrial Fibrillation
Background: Epicardial adipose tissue is associated with prevalent and incident atrial fibrillation (AF). The mechanism for this association has been at least partially attributed...
Abstract 4363087: Calcitonin Gene-Related Peptide (CGRP) Inhibitor Use Is Associated With Increased Cardiovascular Event Risk in Patients with Migraine: A Nationwide Study
Introduction: Calcitonin gene-related peptide (CGRP) inhibitors are increasingly used in the United States (US) for the prevention and treatment of migraine, but population-based d...
Abstract 4363130: Multi-Omic Analyses Identifies Novel Candidate Molecular Drivers of Coronary Artery Calcification
Background: Coronary artery calcification (CAC) is a strong independent predictor of CAD, yet the underlying molecular mechanisms remain incompletely understood. We aimed to identi...
Abstract 4367419: Glucagon-Like Peptide-1 Receptor Agonist Use Is Associated With Lower Risk Of Cardiovascular Event Recurrence Compared With Use Of Bupropion-Naltrexone or Phentermine-Topiramate: A Nationwide Target Trial Emulation Study
Introduction: The Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (SELECT) trial showed that the glucagon-like peptide-1 receptor agonist (GLP1-RA) semaglutide...
Abstract 4371089: Interactions Between Polygenic Risk Scores and Social Determinants of Health in Coronary Artery Disease: Insights from the UK Biobank
Background: While polygenic risk scores (PRS) and social determinants of health (SDOH) are established predictors of coronary artery disease (CAD), interactions between PRS and ind...
Abstract 4372437: Unequal Progress (1990–2021): Global Trends and Socio-Demographic Disparities in Cardiovascular Disease Attributable to High Fasting Plasma Glucose
Background: High fasting plasma glucose (HFPG) is a major metabolic risk factor driving the global burden of cardiovascular disease (CVD). However, temporal trends in HFPG-attribut...
Abstract 4372469: Ambulatory QT Interval Prolongation and Reduced T-Amplitude Help Identify Veterans with Heart Disease
Introduction: Several ECG parameters accessible via ambulatory Holter recordings may help risk-stratify coronary heart disease (CHD) risk, but their clinical use is mostly limited...
Abstract 4373188: Optimal GDMT Use According to Frailty Status Following Diagnosis of HFrEF Among Medicare Fee for Service Beneficiaries
Background: Frailty and HF often co-exist identifying a population at increased risk for CV events. While perceived frailty may be a potential driver of clinical inertia, conventio...
Abstract 4359742: Thrombophilia Variants Do Not Predict Thrombotic Events in Congenital Heart Disease: Insights from the Pediatric Cardiac Genomics Consortium
Background: Thrombotic events are a major complication in patients with congenital heart disease (CHD), particularly those with single ventricle physiology. The contribution of inh...
Abstract 4368171: Stroke Recurrence in Patients with Cryptogenic Stroke and an Implantable Loop Recorder: Impact of Device-Detected Atrial Fibrillation
Background: The implantable loop recorder (ILR) is the most sensitive method for detecting atrial fibrillation (AF) following a cryptogenic stroke. However, to date, no study has d...
Abstract 4367057: Chronic Kidney Disease with Inflammation and Incident Coronary Heart Disease in Black Adults from the Jackson Heart Study
Background: Inflammation and chronic kidney disease (CKD) increase the risk of coronary heart disease (CHD), which disproportionately affects Black adults. However, it remains uncl...
Abstract 4357208: Discrimination in Healthcare and Incident Stroke or Myocardial Infarction
Introduction: People who experience discrimination in healthcare may be less likely to interact with the healthcare system and receive guideline-recommended care, contributing to d...
Abstract 4366125: CHK1 Activates Mitophagy to Attenuate Cardiac Senescence via Inhibiting AHSA1-Ubiquitination
Objective: As one of the classic cell cycle checkpoint proteins, Checkpoint kinase 1 (CHK1) extensively participates in various biological processes primarily through mediating a c...
Abstract 4359302: Incidence, Risk Factors, and Outcomes in Triggered Atrial Fibrillation: Insights from the VITAL-AF Trial
Introduction: Triggered atrial fibrillation (AF), defined as new-onset AF in the setting of a reversible physiological stressor, is common. However, risk factors, outcomes, and man...
Abstract 4368824: Decreased retinoic acid signaling in lung endothelial cells accelerates progression of single ventricle pulmonary arteriovenous malformations
Background: Pulmonary arteriovenous malformations (PAVMs) are vascular complications that universally develop in patients with single ventricle congenital heart disease after Glenn...
Abstract 4353854: An Electronic Health Record Multimodal Data Integration Platform for Comprehensive Analysis of Single Ventricle Physiology
BACKGROUND: Multimodal Electronic Health Record (EHR) data for congenital heart disease (CHD) is challenging to integrate and requires subspecialty expertise across several medical...
Abstract 4360783: Accentuated Effect of Transportation Noise Exposure on Cardiovascular Risk in Individuals with Anxiety and Depression
Background: Stress-related psychiatric conditions (e.g., anxiety, depression) independently increase cardiovascular disease (CVD) risk. This association is mediated by neural-immun...
Abstract 4369795: Impact of Diagnosis-to-Ablation Time on Clinical Outcomes in Patients with Atrial Fibrillation and Pre-Existing Heart Failure after Catheter Ablation: A US Retrospective Cohort Analysis
Background: Atrial fibrillation (AF) and heart failure (HF) often coexist. However, the optimal timing of catheter ablation for AF in patients with pre-existing HF remains uncertai...
Abstract 4361543: Concerning Differences in Major Amputation Trends by Hospital Medicaid Proportion, Patient Income and Race/Ethnicity
Introduction: Recent reports have identified a consistent reversal of decreasing trends in major lower extremity amputations, with multifactorial drivers from cardiovascular diseas...