Circulation
Articles in this Issue
Abstract 4372118: Expanding the Boundaries of Myocardial Protection — The Use of Del Nido Cardioplegia in Pediatric and Adult Cardiac Surgery Within a Controversial Landscape: A Systematic Review and Meta-Analysis of 8,471 Patients
Background: Effective myocardial protection is essential during cardiac surgery to minimize ischemia-reperfusion injury and enhance postoperative recovery. Del Nido cardioplegia (D...
Abstract 4368565: Impact of Concomitant Tricuspid Regurgitation on Outcomes Following Transcatheter Aortic Valve Replacement, 2017-2022
Background: Tricuspid regurgitation (TR) is a prevalent comorbidity among patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), affect...
Abstract Sun308: Outcomes of Extracorporeal versus conventional cardiopulmonary resuscitation for Cardiac arrest: A systematic review and metaanalysis of RCTs and Real World Studies
Background: Cardiac arrest is a major global health concern, contributing significantly to mortality rates. While conventional cardiopulmonary resuscitation (CPR) has long been the...
Abstract 4362660: Evaluating The Incidence And Risk Factors Of Ischemic Stroke After Left Atrial Appendage Closure: A Systematic Review and Meta-Analysis
Background: Left atrial appendage closure (LAAC) is increasingly used to reduce thromboembolic risk in patients with atrial fibrillation (AF) who are unsuitable for long-term antic...
Abstract 4361120: Use Of Glucagon Like Peptide 1 Receptor Agonists In Non Diabetic Patients With Dilated Cardiomyopathy
Background: Glucagon-like peptide 1 (GLP-1) receptor agonists have demonstrated cardiovascular benefits in diabetic patients. However, their role in patients with dilated cardiomyo...
Abstract 4371850: Midterm Rejection and Re-Admission Outcomes in Orthotopic Heart Transplant Recipients with a History of Methamphetamine Use
Background: Methamphetamine Use (MU) is a growing public health concern across the United States and is associated with dilated cardiomyopathy and pulmonary hypertension. For those...
Abstract 4358607: Coronary Artery Calcium and Risk of Cardiovascular Events in Immune-Mediated Inflammatory Disease from the CLARIFY No/Low-Cost CT Calcium Score Registry
Background: Immune-mediated inflammatory diseases (IMID) accelerate atherosclerosis, yet it is unclear whether coronary artery calcium (CAC) scoring captures this excess cardiovasc...
Abstract 4364329: 4D Flow MRI Allows for Enhanced Characterization of Aortic Regurgitation
Introduction: Severe aortic regurgitation (AR) is characterized by significant retrograde blood flow in the aorta and remains difficult to quantitively evaluate by echocardiography...
Abstract 4372286: Social Network Analysis for Clinical Phenotyping of Complex Relationships of Cardiac Cycle Phases Represented in Tissue Doppler Echocardiography of Patients with Heart Failure with Preserved Ejection Fraction
Background: We used Social Network Analysis (SNA) to phenotypic and clinical characterization of tissue Doppler (TD)signals representing different phases of the cardiac cycle in he...
Abstract 4366112: AI-Measured Thoracic Ascending Aortic Calcification in CAC Scans Predicts Cardiovascular Events: An AI-CVD study in the FHS Offspring Cohort
Introduction/Background: The AI-CVD initiative aims to extract opportunistic screening information from coronary artery calcium scans to improve cardiovascular disease prediction....
Abstract 4358022: Predicting Adverse Cardiovascular Events in Patients Receiving Immune Checkpoint Inhibitors
Introduction: Immune checkpoint inhibitors (ICIs) have radically altered cancer therapy. Understanding adverse cardiovascular events (ACEs) associated with ICIs and identifying pat...
Abstract 4370209: PROLONGED PROLIFERATION OF EARLY-STAGE HUMAN PLURIPOTENT STEM CELL-DERIVED VENTRICULAR CARDIOMYOCYTES REDUCES PACEMAKING FUNCTION WHILE PROMOTING MATURATION
Introduction: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold great promise for cell therapy and drug discovery. However, their inherent immaturity, characterize...
Abstract 4367457: Caught Between a Clot and a Bleed: Using Transcranial Doppler Microemboli Monitoring to Determine Anticoagulation Management in a Stroke Patient with Mitral Valve Thrombus and Intracranial Hemorrhage
Description of Case: A 47-year-old female with history of thrombophilia (PAI-1 4G/4G genotype), Barlow syndrome with native leaflet repair then mechanical mitral valve (MV) replace...
Abstract 4365680: Discontinuation of PCSK9 Inhibitor Therapy and Its Impact on Cardiovascular Outcomes in a Japanese Cohort
Background: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors have been shown to effectively lower low-density lipoprotein cholesterol (LDL-C) and reduce the risk of...
Abstract 4343615: Improvements in Cardiometabolic Risk Factors by Body Weight Reduction with Tirzepatide in Adults with Obesity and Prediabetes: A Post Hoc Analysis of the 3-year SURMOUNT-1 study
Background: In the 3-year SURMOUNT-1 study in people with obesity and prediabetes, tirzepatide treatment was associated with significant and consistent body weight reduction, lower...
Abstract 4368666: Prognosis of right bundle branch block in heart failure patients: a reconstructed time-to-event meta-analysis
Background: The growing epidemiologic burden of heart failure (HF) poses a significant public health challenge. The development of conduction abnormalities influences HF outcomes,...
Abstract 4365820: Inhibition of a Cardioprotective miR Family by Cardiomyocyte KLF5 via 3 Circular RNAs
Introduction: Our lab previously demonstrated the cardiotoxic effect of the transcription factor Krüppel-like factor (KLF) 5 in ischemic cardiomyopathy (ICM) in humans and mice. In...
Abstract 4370942: Deep Learning–Based Continuous QT Monitoring Identifies High-Risk Prolongation Events After Class III Antiarrhythmic Initiation
Background: The QT interval is a critical marker for life-threatening arrhythmic risk. Class III antiarrhythmics require inpatient QTc monitoring during initiation, but patients ar...
Abstract 4369970: Predictive Value of Coronary Artery Calcification on the baseline PET/CT or Chest CT for MACE and Mortality in Lung Cancer
Background: Lung cancer is classified into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC – including adenocarcinoma, squamous cell, and large cell carcinoma)....
Abstract 4365796: Cumulative Life-course Blood Pressure Burden and Steepness of Increase Are Associated with Reduced Myocardial Perfusion in Older Age: Insights from MyoFit46
Background: High blood pressure (BP) leads to coronary artery disease. Aim: We explored the impact of...
Abstract 4366800: Renal Function, Atrial Cardiopathy, and Their Joint Association with Mortality in the General Population
Background: Growing evidence suggests that left atrial dysfunction, or atrial cardiopathy, significantly increases mortality risk. Similarly, impaired renal function is a well-esta...
Abstract 4358836: Biological Age and Accelerated Aging as Novel Risk Indicators in Acute Myocardial Infarction
Background: The prevalence of cardiovascular disease increases exponentially with advancing age. However, biological age may differ from chronological age, and the mechanisms contr...
Abstract 4365777: Ubiquinol (coenzyme Q10) and Alpha Lipoic Acid (ALA) Improves Mitochondrial Function in Out- of-Hospital Cardiac Arrest Patients.
Introduction: Out-of-hospital cardiac arrest (OHCA) is associated with severe metabolic and acid-base disturbances, driven in part by mitochondrial dysfunction. Impaired mitochondr...
Abstract 4372750: Trends in Statin Prescribing for Primary Prevention in the United States
Introduction: Cardiovascular disease remains the leading cause of morbidity and death in the US, with coronary disease being the leading cause of death. Statins are a cornerstone o...
Abstract Sat304: Predicting In-Hospital Cardiac Arrest Using Serum Electrolytes and Hemoglobin: A Machine Learning Approach
Background: Limited laboratory (lab) values are recently used to predict in-hospital cardiac arrest (IHCA) by machine learning models. The temporal characteristics of lab values in...