Circulation
Articles in this Issue
Abstract 4339669: Pulmonary Valve Endocarditis with Persistent Enterococcus Faecalis Bacteremia and Multivessel Coronary Artery Disease: A Case of Surgical Valvectomy, Coronary Bypass, and Delayed Bioprosthetic Valve Replacement
Background: Infective endocarditis (IE) is a rare condition (15/100,000 in the US) with nonspecific symptoms, complicating diagnosis. Isolated pulmonary valve IE is exceptionally r...
Abstract 4372871: Thrombin-cleaved osteopontin fragments act on lung CCR2 <sup>+</sup> monocytes to elicit neutrophil retention and hypoxemia in remote lung inflammation after AKI
Background: Acute kidney injury (AKI) complicated by respiratory failure with hypoxemia is common among critically ill patients and associated with high mortality. Previously, we s...
Abstract 4370542: Strength Amidst Strain: Determinants of Resilience in Pediatric and Young Adult Fontan Circulatory Failure
Background: Resilience describes an individual’s ability to leverage internal strengths, external support, and acquired skills to maintain wellbeing amidst stressors. Individuals w...
Abstract 4371333: Diet and Exercise Adaptation to Stress Questionnaire: Development and Initial Psychometric Testing
Background: Allostatic load scores have been used to quantify the physiological pathways in the stress-metabolic relationship, reflecting cumulative physiological "wear and tear" f...
Abstract 4370685: Association Between Food Insecurity and Cardiovascular Risk Factors: A Cross-Sectional Analysis of NHANES Data
Background: Food insecurity is a growing social determinant of health in the United States, with potential implications for cardiovascular disease. However, its relationship with k...
Abstract 4373298: Cellular factor loaded dECM patch improving cardiac function of rats after myocardial ischemia
Background: Ischemic heart disease remains a global health challenge characterized by irreversible cardiomyocyte loss and pathological ventricular remodeling. This study introduces...
Abstract 4360137: Long-Range Chromatin Interaction Mapping Links SNP rs115561468 to Trimethyllysine Metabolism in Coronary Artery Disease
Introduction: Hypoxia and ischemia drive pathogenic vascular remodeling and endothelial cell (EC) dysfunction, leading to the progression of vascular diseases, such as coronary art...
Abstract 4366906: Association of Lipoprotein(a) and Interleukin-6 with Cardiovascular Risk: the Multi-Ethnic Study of Atherosclerosis and UK Biobank
Background: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease (ASCVD) risk, and vascular inflammation is one mechanism through which Lp(a) c...
Abstract 4369306: Cardiovascular and Renal Effects of Physical Training in Male Rats Under Tenofovir Disoproxil Fumarate Treatment
Tenofovir Disoproxil Fumarate (TDF), a crucial antiretroviral for HIV/AIDS and hepatitis B, causes nephrotoxicity and cardiovascular dysfunction (including blood pressure alterations) through oxidativ...
Abstract 4358384: Nitro-oleic acid (CXA-10) prevents cerebral aneurysm formation via endothelial PPARδ activation
Cerebral aneurysms (CA) affect 2-3% of the adult population and remain a potentially lethal disease as they can rupture producing subarachnoid hemorrhage (SAH). Endothelial dysfunction is highlighted...
Abstract 4358464: Prediction of Pregnancy-related Cardiovascular Outcomes Using Electrocardiogram-Derived Cardiorespiratory Fitness
Background: Early identification of women at high risk for pregnancy-related cardiovascular (CV) complications has the potential to significantly reduce maternal mortality. Peak VO...
Abstract 4371592: Long Term Air Quality and Cardiovascular Mortality in Middle Age Adults: A 25-Year Combined Analysis of CDC WONDER and EPA AQS Databases from 2000-2024
Background: Emerging evidence suggests that air pollution is a significant but under recognized contributor to cardiovascular disease (CVD) mortality, even in middle age adults. Th...
Abstract 4370837: WE CHATT: A Pilot Study to Improve Physician-Youth Communication and Medical Decision-Making in Pediatric Advanced Heart Disease
Background: Despite increased survival rates for children with congenital heart disease (CHD), they still face high morbidity, mortality, and complex medical decision-making, parti...
Abstract 4373610: Effect of combined guideline-directed medical therapy and mitochondria-rich extracellular vesicles in a mouse infarct model
Introduction: Beta blockers, renin-angiotensin-aldosterone antagonists, and mineralocorticoid antagonists are mainstays of current guideline-directed medical therapy (GDMT) in hear...
Abstract 4344271: Healthcare Utilization and In-Hospital Outcomes of Atrial Arrhythmias in Coronary Artery Dissection: Insights from National Inpatient Sample (NIS)
Background: Coronary artery dissection (CADx), either spontaneous or iatrogenic, carries high mortality associated with it. Tachycardia induces a shear stress on the blood vessel;...
Abstract 4373396: Treatment and prognosis of aortic diseases related to Kommerell diverticulum: single-center retrospective cohort study
Background and Objective: Kommerell's diverticulum is a special type of proximal subclavian artery aneurysm that is associated with the aberrant subclavian artery. Although most pa...
Abstract 4366954: Leveraging Large Language Models to Extract Parity from the Electronic Health Record and Reveal Hidden Cardiovascular Risk Factors: A Retrospective Study of Takotsubo Cardiomyopathy
Background: Takotsubo cardiomyopathy (TTCM) is a form of heart failure first described in the 1990s that was believed to be triggered by significant emotional events or stressors -...
Abstract 4370430: Sex-Specific Association of Lipoprotein(a) Concentrations with Atherosclerotic Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis
Background: Elevated lipoprotein(a) [Lp(a)] is recognized as a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the precise magnitude of this associa...
Abstract 4358531: Selecting Statins in Primary Prevention: A Comparison by the Pooled Cohort Equation or by the Coronary Artery Calcium Score in Women and Men: The CorCal Outcomes Randomized Clinical Trial
Background: Two methods for selecting statin therapy in primary prevention patients are the pooled cohort equation (PCE), based on traditional risk factors, and coronary artery cal...
Abstract 4370571: Adverse Pregnancy Outcomes and Offspring Cardiovascular Health in Early Adulthood
Introduction: Adverse pregnancy outcomes (APOs) increase the risk for maternal cardiovascular disease, but the effect of APO exposure in utero on offspring cardiovascular health (C...
Abstract 4367471: Efficacy Prediction Score of Hypertension Digital Therapeutics: The Behavioral Modification Index (B-INDEX) Study
Background: Digital therapeutics (DTx) for hypertension are one of the most promising hypertension treatments with proven antihypertensive effects. In this study, we investigated t...
Abstract 4360441: Predictors of Stroke Risk in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis
Background: Coronary artery bypass grafting (CABG) carries a 1–5% risk of stroke, a serious complication linked to increased mortality and healthcare burden. Individual patient and...
Abstract 4368714: Post Index Atrial Fibrillation Ablation Recurrences Over 5 Years: Impact of Ablation Targets Beyond Pulmonary Vein Antra
Background: Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Adjunctive ablation beyond PVI, esp. posterior wall (PW) ablation, has been wide...
Abstract 4365867: Atherosclerotic Cardiovascular Disease Score Underpredicts Five-Year Cardiovascular Risk After Sepsis: External Validation
Background: Sepsis survivors experience substantial long-term cardiovascular (CV) morbidity and mortality. The pooled-cohort atherosclerotic cardiovascular disease (ASCVD) score es...
Abstract 4370167: Endovascular Management of Stanford B Aortic Dissection in a Young Patient with a Thoracoabdominal Aneurysm: A Viable Strategy?
Patient presentation: A 35-year-old woman arrived at the emergency department with a five-month history of intermittent interscapular pain, which evolved hours before admission int...