Circulation
Articles in this Issue
Abstract 4368871: Impact of Glucagon-Like Peptide-1 Agonists on Ventricular Tachycardia Ablation Outcomes: a Matched Analysis
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) have been shown to reduce major cardiac events. However, their impact on ventricular tachycardia (VT) catheter abla...
Abstract 4366483: Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository
Introduction/Background: CHIP is a risk factor for cardiovascular (CV) disease, cancer, and all-cause mortality. Previous work has shown that CHIP, and particularly larger CHIP clo...
Abstract 4370236: A Novel Retrieval-Augmented Generation Approach that Leverages Large Language Models to Parse EHR Data Enhances the Detection of Barriers in Guideline-Directed Medical Therapy Use in Heart Failure
Background: Fewer than half of eligible patients with heart failure (HF) receive all 4 guideline-directed medical therapies (GDMT), despite strong evidence of benefit. Traditional...
Abstract 4368788: The Role and Mechanism of Add3-mediated Pulmonary Artery Smooth Muscle Cell Transformation in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is pathologically characterized by the excessive proliferation of smooth muscle cells (SMCs) and pulmonary artery endothelial cells, leading to progressive narrow...
Abstract 4341683: Sex Differences in Acute Hemodynamic Response to Delta-9-Tetrahydrocannabinol Compared to Placebo: Impact of Cannabis Use Frequency
Introduction: Combusted cannabis is associated with arrhythmia and myocardial infarction in healthy young people. While acute delta-9-tetrahydrocannabinol (THC) increases heart rat...
Abstract 4365885: Covalent Peptidomimetic Targeting NEDD9 Regulates Pulmonary Endothelial Cell Phenotype
Introduction: Knockout of the gene encoding SH3-domain protein NEDD9 mitigates endothelial dysfunction, vascular fibrosis and pulmonary arterial hypertension (PAH)...
Abstract 4342919: Incidence and Early Outcomes of Hypo-attenuated Leaflet Thrombosis after Surgical Aortic Valve Replacement with Inspiris Resilia Valve
Introduction: Hypo-attenuated leaflet thickening (HALT) is a type of thrombotic lesion that has been identified frequently in recent times owing to the widespread use of transcathe...
Abstract 4363004: Time-Dependent Impact of the 2018 UNOS Heart Allocation Policy Revision on Transplantation and Waitlist Outcomes: A Landmark Competing Risks Analysis
Background: While early data following the 2018 United Network for Organ Sharing (UNOS) heart allocation policy revision showed improved transplantation rates and reduced waitlist...
Abstract 4366871: Co-existence And Prognosis of 18FDG-avidity And Genetic Cardiomyopathies
Introduction: 18FDG-PET scan has emerged as a modality for identifying inflammatory cardiomyopathies such as cardiac sarcoidosis (CS) by detecting glucose uptake. Guidelines allow...
Abstract 4344686: Impact of Diabetes and Glycemic Control on Cardiovascular Outcomes Following Left Atrial Appendage (LAA) Occlusion: A Propensity Matched Analysis.
Background: Diabetes mellitus is a known risk factor for adverse cardiovascular outcomes, particularly in patients with atrial fibrillation. While left atrial appendage occlusion (...
Abstract Sat707: Prehospital Patient Monitoring and Ventilation Management During Pediatric Out-of-Hospital Cardiac Arrest Care
Introduction: Pediatric out-of-hospital cardiac arrest (P-OHCA) is far less common than adult OHCA with limited improvement in outcomes despite decades of progress in adults. Effec...
Abstract 4369018: Outcomes Following Heart Transplantation in Patients Bridged with Extracorporeal Membrane Oxygenation alone vs with additional Impella devices: A Retrospective National Registry Study
Background: Venoarterial extracorporeal membrane oxygenation (ECMO) is commonly used as a bridge to heart transplantation in patients with cardiogenic shock. The addition of a perc...
Abstract 4371611: Timing Matters: Hypertensive Pregnancy Outcomes by Admission Day
Introduction: Chronic hypertension (CHTN) in pregnancy is defined as blood pressure ≥140/90 mmHg diagnosed before pregnancy or before 20 weeks’ gestation. Clinically distinct from...
Abstract 4366423: Breaking the Barrier: RAGE Deficiency Promotes EndoMT and Male-Predominant Pulmonary Arterial Hypertension
Background: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease initiated by injured pulmonary artery endothelial cells (PAECs). Although PAH disproportionatel...
Abstract 4359066: Free Right Internal Mammary Artery vs In-situ Right Internal Mammary Artery as a Second Conduit for Coronary Artery Bypass Surgery: A Meta-Analysis
Background: In coronary artery bypass grafting (CABG), left internal mammary artery (LIMA) grafting to the left anterior descending coronary artery is the established gold standard...
Abstract 4364302: Neuroprotective Effect of Nitroxoline Against Transient Global Cerebral Ischemia in Rats Through Attenuation of Bromodomain-Containing Protein 4 and Downstream Pathway
Introduction: Bromodomain-containing protein 4 (BRD4), a member of the BET family, functions as an epigenetic reader and plays a pivotal role in regulating transcriptional response...
Abstract 4371176: Changes in Subcortical Iron Deposition in Adolescents and Young Adults with Fontan Circulation
Introduction: Fontan palliation surgery is the final step in a series of three operations to treat underdeveloped ventricles in patients with single ventricular heart disease. Font...
Abstract 4356836: Finerenone Versus Spironolactone in Patients With Heart Failure With Preserved Ejection Fraction: A Real-World Comparative Analysis
Background: Heart failure with preserved ejection fraction (HFpEF) remains a major therapeutic challenge with limited pharmacologic options that improve outcomes. While mineralocor...
Abstract 4369513: Statin Therapy For Primary Prevention Of Anthracycline-Induced Cardiotoxicity:A Systemic Review And Meta-Analysis
Introduction: One of the major adverse effects of cancer chemotherapeutic agents, particularly anthracyclines, is therapy-related cardiac dysfunction. This created a need to develo...
Abstract 4367832: Impact of Anticoagulation on Outcomes of Direct Current Cardioversion in Patients with a Left Atrial Appendage Occlusion Device
Background: Direct current cardioversion (DCCV) is a standard intervention for restoring sinus rhythm in atrial fibrillation (AF). Left atrial appendage closure (LAAC) devices prov...
Abstract 4366171: One Model Does Not Fit All: Demographic Disparities in Machine Learning-Based Prediction of 30-Day Readmission Following Acute Myocardial Infarction
Background: Machine learning (ML) models are increasingly used to predict clinical outcomes such as 30-day readmission following acute myocardial infarction (AMI). However, most mo...
Abstract 4363336: A Multicenter Observational Study of Bleeding Events in Critically Ill Surgical and Trauma Adolescents
Bleeding complications represent a significant concern in intensive care settings, with 5-6% of critically ill adults developing major bleeding and up to 85% experiencing minor bleeding events. In cri...
Abstract 4367284: Hospital Admissions With Hypertensive Emergency Increased While Admissions With Asymptomatic Elevated Inpatient Blood Pressure Decreased From 2014-2024: A Nationwide Study
Introduction: Hypertension is common in acute care settings, and there is controversy on the best management depending on severity of elevation and the presence of end-organ damage...
Abstract 4369637: Center-Based, Home-Based, and Technology-Enhanced Cardiac Rehabilitation Equally Reduce Mortality Risk in Veterans
Introduction: Cardiac rehabilitation (CR) is a class I recommendation following a cardiac event, yet fewer than 20% of eligible patients enroll. Home-based CR (HBCR), especially wh...
Abstract 4351008: Comparing Cardiovascular Outcomes in New Users of Oral Semaglutide Versus Other Noninsulin Glucose-Lowering Therapies
Background: Clinical trial and real-world evidence has shown the cardiovascular (CV) benefit from once-weekly semaglutide in people with type 2 diabetes (T2D) and atherosclerotic c...