Circulation
Articles in this Issue
Abstract 4369247: Hemolysis-induced Endothelial Necroptotic Signaling Pathways: Insights in the Mechanisms of Acute Chest Syndrome in Sickle Cell Disease
Backround: There is a life expectancy disparity of nearly 20 years in sickle cell disease (SCD) patients. Cardiovascular and pulmonary complications are major contributors to morta...
Abstract 4344258: A Machine Learning Algorithm to Detect Pediatric Supraventricular Tachycardia Risk from Baseline ECGs
Background: Atrioventricular nodal reentrant tachycardia (AVNRT) is a common form of supraventricular tachycardia (SVT) in childhood resulting from dual AV nodal physiology (DAVNP)...
Abstract 4360121: PD-1-deficient Dendritic Cells Show Reduced Lysosomal Activity in a Model of Immune Checkpoint Inhibitor-associated Myocarditis
Introduction: Although immune checkpoint inhibitors (ICIs) have transformed cancer therapy, they can cause immune-related adverse effects, including ICI myocarditis, a potentially...
Abstract 4361783: Time Since Menopause Shapes Women's Metabolome and Cardiovascular Risk
Introduction: The risk of cardiovascular disease (CVD) increases significantly after menopause in women. However, the metabolic mechanisms underlying this association remain insuff...
Abstract 4370893: Joint Associations Between Social and Psychological Health Risk and Life’s Essential 8 Among Women of Reproductive Age: Insights from the SAFE HEART Study
Background: Cardiovascular disease (CVD) is a leading cause of morbidity among women of reproductive age. Social and psychological adversities may worsen cardiovascular health, but...
Abstract 4363028: Recurrences of the Infective Endocarditis: are we looking hard enough? Results from the Polish Infective Endocarditis Registry (POL-ENDO
Background: Patients with prior infective endocarditis are associated with an increased risk of recurrence. Aims:...
Abstract 4365556: Heart of the Desert: How Food Inaccessibility Fuels Cardiac Mortality
Background: Food deserts - areas with limited access to affordable, nutritious foods - are increasingly recognized as contributors to adverse cardiovascular outcomes. Prior individ...
Abstract 4368041: Perioperative Outcomes of Non-Cardiac Surgery Early after Transcatheter Aortic Valve Implantation
Introduction: Approximately 17.2 million inpatient noncardiac surgeries (NCS) are performed annually in the US. Risk assessment prior to NCS is critical to mitigate perioperative m...
Abstract 4338227: Glycemic Status Modifies the Prognostic Value of the Cardiometabolic Index for Cardiorenal Outcomes: Evidence From a Population-Based Cohort Study
Background: The Cardiometabolic Index (CMI) is linked to cardiovascular and metabolic diseases, but its prognostic value for cardiorenal syndrome (CRS) and the modifying role of gl...
Abstract 4368563: Progression of Fontan Associated Liver Disease (FALD) Leads to a Metabolic Transformation in Hepatocytes
Background: Single-ventricle congenital heart disease is a rare and lethal cardiac abnormality that disrupts normal circulation in neonates. The cavopulmonary redirection of blood...
Abstract 4369530: Automated Aortic Valve Calcification Scoring: Multicenter External Validation of a Deep Learning Algorithm
Introduction/Background: Aortic valve calcification (AVC) quantification is recommended by guidelines as an imaging biomarker for aortic stenosis (AS) severity and progression yet...
Abstract 4365494: Mitochondrial Perinuclear Polarity Distribution Promotes Mammalian Heart Regeneration
Background: Irreversible myocardial injury and replacement fibrosis following myocardial infarction (MI) constitute key drivers of cardiac dysfunction. Consequently, promoting endo...
Abstract Or105: <i>“If it Can Help Someone, Then They Want to Do It”:</i> Demonstrating Feasibility of End-of-Life Studies to Support Development and Validation of Cardiac Arrest Detection Technologies with Consumer Smartwatches
INTRO: Most out-of-hospital cardiac arrest (OHCA) cases are unwitnessed, leading to poor survival. Wearable devices have been proposed to notify first responders that an OHCA has o...
Abstract Sat502: Exploring Nurse Emergency Responder Confidence with Advanced Resuscitation Training
Training for nurse emergency responders (NER) vary nationally. Many NER do not receive training outside of basic or advanced life support certifications. At a Level 1 Academic Trauma Center (L1ATC), e...
Abstract 4365560: Management of Mechanical Mitral Valve Thrombosis Using Multimodal Imaging and Thrombolysis
Case Description: A 66 year old female with past medical history of rheumatic heart disease requiring mechanical mitral valve (MV) replacement on warfarin, HFpEF (EF 60%), atrial f...
Abstract 4367334: Amiodarone Use in Left Ventricular Assist Devices Patients Is Associated with Increased Risk of Mortality and Adverse Events: A Real-World Analysis from the TriNetX Platform
Background: Amiodarone is commonly prescribed to manage arrhythmias in Left Ventricular Assist Devices (LVADs) patients. However, its safety profile in this population remains uncl...
Abstract 4337300: Evaluating the Atherogenic Index of Plasma as a Prognostic Indicator for Readmission Risk in Heart Failure Patients: A Retrospective Cohort Study
Aims: Among patients who are hospitalized with heart failure (HF), about 50% have readmissions within 6 months. The impact of atherogenic index of plasma (AIP) and low-density lipo...
Abstract 4362601: Twenty-Five Years of Angina Mortality Among Elderly Adults: CDC WONDER-Based Insights
Background: Angina Pectoris is a potentially life-threatening cardiovascular condition associated with significant morbidity, and mortality in adults aged >65 years. We assessed...
Abstract 4368269: Association between Glucagon-like peptide-1 receptor agonists and risk of Arrhythmias: A Contemporary Real-World Analysis
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially designed to treat type 2 diabetes mellitus, have demonstrated the potential to mitigate obesity-related...
Abstract 4358353: Three-Dimensional Echocardiographic Evaluation of Right Ventricular Dysfunction in Chronic Obstructive Pulmonary Disease
Introduction: Right ventricular (RV) dysfunction is a significant contributor to morbidity in chronic obstructive pulmonary disease (COPD), yet often remains underdiagnosed. Advanc...
Abstract 4371146: Risk Factors for Cardiovascular Disease patients at Health Care for the Homeless clinics versus Community Health Centers
Background: Cardiovascular disease (CVD) is the number one cause of mortality in the United States and those experiencing homelessness are at a higher risk for developing CVD. The...
Abstract 4364593: Protective Role of Larp6 in Atherosclerosis: Promoting Features of Plaque Stability and Smooth Muscle Cell Survival
Introduction: Acute plaque rupture followed by luminal thrombosis is a major cause of myocardial infarction and sudden cardiac death. Vulnerable plaques are characterized by a thin...
Abstract 4365687: Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
Background: The arteriovenous fistula (AVF) is a requirement for hemodialysis therapy in end-stage kidney disease (ESKD) patients. A consequence of AVF creation is compensatory car...
Abstract 4371471: Speech-Based Smartphone App Improves Adherence to Remote Monitoring in Rural Heart Failure Patients
Background: Heart failure is a major driver of hospitalizations and readmissions in older adults. Remote patient monitoring (RPM), including tracking blood pressure, weight, heart...
Abstract 4339510: Human induced pluripotent stem cells derived nanovesicles for cardiomyocyte proliferation
Background: It is well-known that cardiomyocytes (CMs) in adult mammalian hearts lose capacity to proliferate. Although cardiogenic potential of human induced-pluripotent stem-cell...