Circulation
Articles in this Issue
Abstract 4342694: Body Composition and Physical Activity Predictors of Vascular Health in Premenopausal and Postmenopausal Asian Women: A Comparative Analysis
Background: Menopause is associated with adverse changes in vascular function that significantly increase vessel stiffness and cardiovascular disease (CVD) risk. Given the rising C...
Abstract 4372928: Outpatient Cardiac Rehabilitation after Transcatheter Mitral Valve Repair is Associated with Reduced Mortality and Heart Failure Decompensation
Background: Transcatheter mitral valve repair (TMVr) is increasingly being used to treat severe mitral regurgitation in patients at high surgical risk. While cardiac rehabilitation...
Abstract 4358030: Development and Validation of a Clinical Polygenic Risk Report for Cardiometabolic Disease in a US-Based Health System
Background: As genomic data becomes more readily available, there is growing demand for tools to translate genetic risk into actionable insights for patients. We introduce a novel...
Abstract 4368562: Self-Efficacy Partially Mediates the Association Between Shared Decision Making and Self-Reported Health Status Among US Adults and Those Living with Cardiometabolic Diseases
Background: Shared decision-making (SDM) is recommended to improve health outcomes among adults with cardiometabolic diseases (CMD). Prior studies have suggested that SDM may impro...
Abstract 4368767: Persistent Statin Underutilization in Cancer Survivors for Primary Prevention NHANES (2013-2020)
Background: Cancer survivors are at an increased risk of cardiovascular disease (CVD) due to shared risk factors and the cardiotoxicity of cancer therapies. While statins are widel...
Abstract 4361539: Long-term Outcomes of Leadless versus Transvenous Single-chamber Pacemaker in Elderly Patients
Background: Leadless pacemaker has emerged as a promising alternative to traditional transvenous pacemaker (PM) among elderly patients who are at high risk of complications....
Abstract 4370667: Right Ventricular Free Wall Strain and Clinical Outcomes in Transthyretin Amyloid Cardiomyopathy and Effect of Vutrisiran: the HELIOS-B Study
Introduction: Right ventricular dysfunction is common among patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and is associated with worse prognosis. In HELIOS-B, vutris...
Abstract 4366573: Neonatal Resource Utilization following False Positive Prenatal Diagnosis of Coarctation of the Aorta
Introduction: Prenatal diagnosis of coarctation of the aorta (COA) is challenging and associated with high false positive rates. Postnatal confirmation of the diagnosis is frequent...
Abstract 4367357: Enrollment strategies that yield a representative and generalizable trial population for hypertension research.
Background: Clinical trial participants often do not represent patients with hypertension in the real world, which limits the generalizability of findings. In our pragmatic multice...
Abstract 4360506: Effect of Fluid Restriction in Heart Failure: A Meta-Analysis of Randomized Controlled Trials
Background: Optimal fluid management is central to heart failure (HF) care, yet the clinical efficacy of fluid restriction remains inconclusive. This updated systematic review and...
Abstract 4367119: Maternal Vascular Endothelial Growth Factor Signaling and Hospital Length of Stay Association in Hypoplastic Left Heart Syndrome Post Stage One Palliation
Background: Neonates with critical congenital heart disease (CHD) have significant variability in outcomes not explained by traditional risk factors. Previous work showed that preg...
Abstract 4367590: Sex Differences in Long-Term Outcomes Following Transcatheter Closure of Patent Foramen Ovale
Introduction: Limited data suggest that closure of a patent foramen ovale (PFO) may be more effective in preventing stroke in men than in women. We aimed to assess sex-based differ...
Abstract 4345167: A Contemporary Machine Learning-Based Risk Stratification for Mortality and Hospitalization in Heart Failure with Preserved Ejection Fraction Using Multimodal Real-World Data
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous condition with high morbidity and mortality. Risk stratification of patients with HFpEF is imp...
Abstract 4371662: Sex-Specific Differences in Outcomes of Cardiogenic Shock Among Patients with Diabetes Mellitus: A Systematic Review
Introduction: Cardiogenic shock (CS) is a life-threatening condition characterized by reduced tissue perfusion due to cardiac pump failure. In patients with diabetes mellitus (DM),...
Abstract 4368236: Safety of Intracardiac Echocardiography Use in Transcatheter Aortic valve Replacement in comparison to Transesophageal Echocardiography: A National Inpatient Sample study
Introduction: Transesophageal echocardiography (TEE) has been widely used for imaging guidance during Transcatheter aortic valve replacement (TAVR) . However, the use of intracardi...
Abstract 4366827: Large Language Models Detect Ventricular Tachycardia Recurrence in Clinical Notes and Enable Prediction of Clinical Outcomes at Scale
Introduction: Predicting recurrence in patients with Ventricular Tachycardia (VT) remains challenging, and manual screens of clinical notes are laborious. Advances in natural langu...
Abstract 4369171: Relationship between cholesterol efflux capacity measured by a clinical applicable immobilized liposome-bound magnetic beads method and the lipid-to-protein composition of cholesterol acceptor
Introduction/Background: Cholesterol efflux capacity (CEC) is one of the atheroprotective functions exerted by cholesterol acceptors such as high-density lipoproteins (HDL) or apol...
Abstract 4364057: Structured Workflow Integration Improves Polyneuropathy Screening and Multidisciplinary Care for Patients with Hereditary Transthyretin Amyloidosis
Background: Patients with hereditary transthyretin amyloidosis (ATTRv) are often referred for cardiac evaluation, resulting in a primary focus on transthyretin amyloid cardiomyopat...
Abstract 4373350: Efficacy of GLP-1 Receptor Agonists VS SGLT2 Inhibitors on Cardiovascular Outcomes in Women with Type 2 Diabetes and Premature Coronary Artery Disease: A Propensity Score Matched Analysis
Background: Premature Coronary artery disease (CAD) in women is typically defined as coronary artery disease before age 55. This condition is becoming increasingly recognized, howe...
Abstract 4347320: JAK3 Promotes TIA1-Mediated Phase Separation to Drive Neointimal Hyperplasia in Vein Grafts
Vein graft failure remains a major challenge after coronary and peripheral bypass surgeries, primarily due to neointimal hyperplasia driven by vascular smooth muscle cell (SMC) phenotypic switching. T...
Abstract 4342014: Association of ACKR1 Genotype with Cancer Risk in Participants with African Ancestry in the ARIC study
Background: Individuals of African ancestry typically express a null variant in the Duffy antigen receptor for chemokines (DARC), encoded by the ACKR1...
Abstract 4366118: Assessing Social and Clinical Determinants of Hospital Length of Stay Among Emergency Department Patients with Acute Heart Failure
Introduction: Acute Heart Failure (AHF) is the leading cause of hospitalization in adults over 65. Prolonged hospital stays increase morbidity and costs. While clinical severity is...
Abstract 4349014: A Perfect Storm: Simultaneous Pulmonary Embolism, STEMI, and Stroke via Paradoxical Embolism in a Hospitalized Patient on DVT Prophylaxis
Background: Simultaneous cardio-cerebral embolism is rare, and its co-occurrence with pulmonary embolism (PE) is exceedingly uncommon. This triad often results from paradoxical emb...
Abstract 4370671: TERRA Downregulation and Pathway Alterations in a Murine Model of Neurohormonal Heart Failure
Heart failure (HF) remains a leading cause of mortality worldwide, exacerbated by age-related myocardial degeneration. Our prior work demonstrated that cardiomyocyte telomere shortening, a hallmark of...
Abstract 4357468: Predictive Utility of Genomics, Inflammation, Cholesterol, and Lipoprotein(a) in Assessing Coronary Artery Disease Risk Across Age and Sex
Background: Coronary artery disease (CAD) polygenic risk score (PRS), low-density lipoprotein cholesterol (LDL-C), lipoprotein(a) [Lp(a)], and high-sensitivity C-reactive protein (...