Circulation
Articles in this Issue
Abstract 4363205: The Effect of the COVID-19 Public Health Emergency on Cardiovascular Care and Cardiac Rehabilitation Access and Use
Background: The COVID-19 Public Health Emergency (PHE) disrupted access to cardiac procedures and cardiac rehabilitation (CR) nationwide. Less is known about the long-term impacts...
Abstract 4368827: Impact of Timing of Repeat Catheter Ablation on Long-Term Atrial Fibrillation Recurrence: Insights from the ITHACA Database
Background: Recurrent atrial fibrillation (AF) following catheter ablation remains a significant clinical challenge, affecting 20–40% of patients. While current guidelines recommen...
Abstract 4369518: Between Risk and Return: Predicting Gaps In Care For Those With Congenital Heart Disease Through Machine Learning and Social Risk Modeling
Introduction/ Background: Lifelong continuity of care is essential for individuals with congenital heart disease (CHD). Despite guidelines recommending uninterrupted follow-up, gap...
Abstract 4361963: 4D Flow MRI Evaluation of Cardiovascular Risk-Related Alterations in Heart-Brain Hemodynamics in Cognitively Healthy Aging Adults
Background: Cardiovascular (CV) risk factors such as hypertension have been linked to accelerated cognitive decline with aging but underlying hemodynamic mechanisms are unclear. Ao...
Abstract 4359272: Associations Between Food Insecurity and Life’s Essential 8 Metrics Among Women of Reproductive Age in the SAFE HEART Study
Introduction: Food insecurity, a critical social determinant of health, that affects many women of reproductive age, particularly those living in communities at high risk for cardi...
Abstract 4355277: Decoding Mechanosensitive Genes in Cardiac Fibroblasts via 3D Hydrogel Models of Fibrosis
Cardiac fibrosis arises from the abnormal activation of cardiac fibroblasts (CFs) in response to both chemical and mechanical stressors. While extracellular matrix (ECM) stiffness is a key determinant...
Abstract 4359716: Downregulation of Cytosolic Connexin-43 in Left Ventricular Myocardium of Dogs with Chronic Heart Failure and Recovery After Treatment with β3-Adrenergic Receptor Antagonist
Background: Cytosolic Connexin-43 (Cx43) plays a crucial role in the formation of gap junctions. Proper levels, localization, function, and interactions of Cx43 with other proteins...
Abstract 4360589: A New Comprehensive Parameter Residual C-Reactive Protein And Neutrophil Risk Predict Adverse Events In Chinese Patients After Percutaneous Coronary Intervention: a National Multi-Center Prospective Cohort Study
Objectives: High-sensitivity C-reactive protein (hsCRP) and the neutrophil-lymphocyte ratio (NLR) are independent and validated inflammatory markers that predict cardiovascular eve...
Abstract 4363062: BRCC3 inhibition of EndoMT via deubiquitination of Smad7: Implication in Atherosclerosis
Background: Endothelial-to-mesenchymal transition (EndoMT), driven by the TGF-β/Smad2/3 signaling, contributes to endothelial dysfunction and atherosclerosis. BRCC3 is a K63-depend...
Abstract 4370502: Navigating the Cold Front: Challenges in Cardiac Surgery for Cold Agglutinin Disease
Background: Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia that poses critical challenges during cardiopulmonary bypass (CPB). Exposure to hypothermia during c...
Abstract 4368907: Anasplasmosis with a Twist: Polymorphic Ventricular Tachycardia and Sudden Cardiac Arrest
Introduction: Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum, is a tick-borne illness ranging in manifestation from mild febrile syndromes to life-threa...
Abstract Sun407: Race and ethnicity based disparities in hypotension and treatment after OHCA
Introduction: Minority out-of-hospital cardiac arrest (OHCA) patients suffer from worse outcomes, and research suggests that differences in hospital care may significantly contribu...
Abstract 4370855: Biventricular Cardiac Metastasis of Cutaneous Melanoma: Imaging-Guided Treatment Strategy with Check-Point Inhibition and Debulking Surgery
Background: Melanoma frequently spreads hematogenously, yet cardiac metastases remain under-recognized and carry high mortality. Early identification and coordinated cardio-oncolog...
Abstract 4366988: Vascular Recovery from Ischemia: Role of mRNA Base Modification
Background: We have described the role of angiogenic transdifferentiation as a response to ischemia. Specifically, in the setting of ischemia, a subset of tissue fibroblasts transd...
Abstract 4373134: Impact of Hyper-Polypharmacy on Cardiovascular Outcomes in Patients With Acute Coronary Syndrome: Analysis Form the ATLAS ACS 2-TIMI 51 Trial
Background: Polypharmacy is increasingly prevalent among patients with acute coronary syndrome (ACS) due to the burden of multimorbidity and guideline-recommended therapies. Howeve...
Abstract 4369381: Regulation of Nav1.5 Channel Surface Expression and Function by Sorbs2 in Atrial Cardiomyocytes
Background: Voltage-gated Nav1.5 channel, encoded by SCN5A , is essential for initiation and propagation of action potentials (AP) in atria....
Abstract 4362785: In vivo generation of CAR-M via LNP-mRNA targeting macrophages for immunotherapy in cardiac repair
Background: Inflammatory response is a crucial mechanism in the development and progression of heart failure following ischemic cardiac injury, partly because the delayed clearance...
Abstract 4365747: Postoperative Outcomes for Patients with Single Ventricle and Major Aortopulmonary Collaterals
Background: In single ventricle (SV) cases with pulmonary stenosis or atresia, where pulmonary blood flow is supplied by major aortopulmonary collateral arteries (MAPCAs), early un...
Abstract 4361637: Cognitive Impairment Impedes the Acquisition of Self-Care Management Skills in Patients with Heart Failure
Background: Cognitive impairment (CI) is prevalent among patients with heart failure (HF) and is associated with adverse outcomes. Effective self-care management is crucial in prev...
Abstract 4367267: Trends in Stroke-Related Mortality Among U.S. Patients with Hyperlipidemia, 1999–2020: A CDC WONDER Analysis
Background: Stroke-related mortality has been rising in the United States. Understanding its association with modifiable risk factors, such as hyperlipidemia (HLD), is critical for...
Abstract Or113: Rescue Breathing Makes a Difference: Superior Neurological Outcomes with Conventional CPR in Drowning-Related Cardiac Arrest
Introduction: The effectiveness of compression-only cardiopulmonary resuscitation (CPR) has been well-documented in cardiac-origin out-of-hospital cardiac arrest (OHCA). However, f...
Abstract 4365966: Who’s Left Behind? Exploring the Digital Divide in Health App Use Among Adults with Hypertension and Diabetes
Background: Mobile health applications (apps) offer promising tools for managing chronic conditions like hypertension and diabetes. However, disparities in access and use—often ref...
Abstract 4364249: Mitral Valve Prolapse and Ventricular Arrhythmia Risk in <i>TTN</i> -Mediated Cardiomyopathy
Introduction: Titin truncating variants (TTNtv) are a common cause of dilated (DCM) and non-dilated left ventricular cardiomyopathy (NDLVC). Mitral valve prolapse (MVP) occurs comm...
Abstract 4367324: Artificial Intelligence ECG Model To Reduce False-Positive STEMI Alerts in the Emergency Department
Introduction: Current STEMI alert pathways triggered in the emergency department often result in high false-positive rates and frequent cancellations by cardiology. AI-based ECG an...
Abstract 4371243: Analysis of Discrepancies Between Radiologist and AI CCTA Readings Across Clinical Thresholds
Background: CCTA informs clinical decisions with stenosis thresholds that guide treatment, testing, and insurance approval. AI-based tools may reduce interpretative variability, bu...