Circulation
Articles in this Issue
Abstract 4363863: Does Lipoprotein(a) Associate with In-Stent Neoatherosclerosis and Plaque Vulnerability Detected by Optical Coherence Tomography in Patients with Acute Coronary Syndrome?
Background: Recently, lipoprotein(a) [Lp(a)], a genetically determined low-density lipoprotein-like particle, has been recognized as a potential therapeutic target for residual car...
Abstract Or109: Lactate-Pyruvate Ratio is Associated with Noninvasive Optical Measures of Cerebral Oxygenation in an Experimental Pediatric Model of Cardiac Arrest
Introduction: Early and accurate prediction of neurological injury during cardiopulmonary resuscitation (CPR) is vital for guiding clinical decisions and improving outcomes followi...
Abstract 4362776: Multimodal and Serial Electrocardiogram and Chest X-ray Age Have Prognostic Significance as Biomarkers for Cardiovascular Health
Background: Estimating biological age from diagnostic tests such as electrocardiograms (ECGs) and chest X-rays (CXRs) via artificial intelligence (AI) is an emerging strategy for c...
Abstract 4369568: Hide and Seek: Post-Procedural Imaging After Catheter Ablation for Atrial Fibrillation in ACHD Patient
Atrial fibrillation occurs in a growing number of adults with congenital heart disease (ACHD); however, recommendations for procedural considerations are lacking. A 43-year-old woman...
Abstract 4366996: Forecasting the Onset of Atrial Fibrillation in the Intensive Care Unit Using Real-World Telemetry Data
Background: Paroxysmal atrial fibrillation (AF) is a common arrhythmogenic complication in the intensive care unit (ICU) associated with significant costs and morbidity. AF detecti...
Abstract Sat1308: Cardiogenic Shock: Characteristics of Patients Who Receive or Do Not Receive Mechanical Circulatory Support
Background: Cardiogenic Shock (CGS) is the most common cause of death in hospitalized patients with Acute Myocardial Infarction (AMI). This study identified the characteristics of...
Abstract 4366051: Infective Endocarditis Masquerading as MRSA Pericardial Tamponade: A Rare Diagnostic Pitfall
Background: Purulent pericarditis is a very rare manifestation of infective endocarditis (IE) with a high mortality rate, particularly in the setting of Methicillin-resistant Staph...
Abstract 4368743: Macrophage Lipid Handling Is Altered in a Mouse Model of a Human Polymorphism that Results in CD73 Loss-of-Function
Background: Atherosclerotic cardiovascular disease (ASCVD) remains the leading global cause of death. Purinergic signaling, mediated by ectonucleotidases like CD73, plays a critica...
Abstract 4369471: Impact of Diagnosis-to-Ablation Time on Clinical Outcomes in Patients with Atrial Fibrillation after Catheter Ablation: A US Retrospective Cohort Analysis
Background: Current clinical guidelines underscore the importance of rhythm control using catheter ablation but lack guidance regarding the timing of atrial fibrillation (AF) ablat...
Abstract 4338261: Astrovirus-Myopericarditis Leading to Sudden Cardiac Arrest; An Unusual Complication of Common Gastroenteritis
Case Description: A 27-year-old male with unremarkable past medical history presented with non-bloody diarrhea and nausea and vomiting of 5 days duration. While in the emergency de...
Abstract 4365727: The role of fibroblast activation protein on left ventricular geometry, growth and extracellular matrix remodeling with pressure overload
Background: Fibroblast activation protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to extracellular matrix (ECM) remodeling. However, the role...
Abstract 4365706: Integrative Transcriptional Analysis Identifies the Metabolic Signatures Between Dilated Cardiomyopathy and Hypertrophy Cardiomyopathy
Objective: Dilated Cardiomyopathy (DCM) and Hypertrophic Cardiomyopathy (HCM) are two major forms of heart diseases characterized by different pathological mechanisms. DCM is often...
Abstract 4359912: Standard Modifiable Risk Factors and Severity of Coronary Artery Disease in Very Young Patients with Myocardial Infarction
Introduction: Myocardial infarction (MI) in individuals ≤35 years is poorly characterized. The prevalence of standard modifiable cardiovascular risk factors (SMuRFs) and their impa...
Abstract 4366008: Disaggregating Cardiovascular-Kidney-Metabolic Mortality among Asian Subgroups in the United States
Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a growing cause of mortality, shaped by both biological and social determinants of health. Given the heterogeneity wit...
Abstract 4365476: The Klotho Protein Reduces Vascular Calcification via Suppressing GPX4-mediated Ferroptosis in Vascular Smooth Muscle Cells
Objectives: Chronic kidney disease (CKD) patients exhibit elevated cardiovascular risk linked to vascular calcification—pathological calcium-phosphate deposition impairing vascular...
Abstract 4369768: Parental Education and Cardiovascular Risk Factors in South Asian Young Adults in the United States: The MASALA-2G Second Generation Study
Introduction: Social determinants of atherosclerotic cardiovascular disease (ASCVD) risk factors in second generation, young adult South Asians have not been investigated. Individu...
Abstract 4368699: IVUS-Guided Management of Suspected Left Main Compromise During High-Risk TAVR
Background: Acute coronary obstruction (ACO) is a rare but potentially fatal complication of transcatheter aortic valve replacement (TAVR), particularly in patients with high-risk...
Abstract 4371987: Fenestrated Endovascular Aneurysm Repair (FEVAR) versus Chimney Endovascular Aneurysm Repair (Ch-EVAR) vs Open Surgical Repair for the Treatment of Abdominal Aortic Aneurysm (AAA): A Systematic Review and Network Meta-Analysis of Intra-operative Mortality and Renal Failure
Introduction: Abdominal aortic aneurysms (AAA) come with significant treatment challenges. While open surgical repair (OSR) has been the traditional approach, fenestrated endovascu...
Abstract 4370374: Association of TTR-Targeted Therapies with Cardiovascular Outcomes in Transthyretin Amyloid Cardiomyopathy: A Real-World Analysis
Background: Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a progressive, infiltrative disease caused by deposition of misfolded transthyretin (TTR) amyloid fibrils in the myoca...
Abstract 4357547: Epicardial fat thickness as a marker of coronary artery disease in diabetics: A single center study.
Background: Epicardial fat thickness (EFT) has emerged as a potential marker for coronary artery disease (CAD) due to its proximity to coronary vessels and its pro-inflammatory pro...
Abstract 4365681: Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α
Background/Significance: Exercise training induces physiological cardiac hypertrophy, mitochondrial biogenesis and myocardial function. In skeletal muscle, the transcriptional coac...
Abstract 4366302: Specific Fungal Species Supplementation Augments Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension
Introduction: Right ventricular dysfunction (RVD) is the greatest predictor of outcomes in pulmonary arterial hypertension (PAH). Inflammation is a major driver of RVD. The intesti...
Abstract 4359746: Safety and Feasibility of Hyperkalemic Cardioplegia with Diazoxide in Cardiac Surgery: CPG-DZX Trial
Introduction: Adenosine triphosphate-sensitive potassium (K ATP ) channel opener diazoxide (DZX) is cardioprotective in multiple translation...
Abstract 4358540: Machine Learning For Precision Phenotyping and Genomic Discovery for Heart Failure with Preserved Ejection Fraction
Introduction: Heart failure with preserved ejection fraction (HFpEF) affects over 32 million people globally, and has a 30% mortality within one year of first hospitalization. Curr...
Abstract 4367824: The Dual Threat: BRASH Syndrome Triggered by Beta Blockers and Calcium Channel Blockers
Case Description: BRASH syndrome is characterized by the following: bradycardia, renal failure, atrioventricular blockade, shock, and hyperkalemia. Due to its overlapping features,...