Circulation
Articles in this Issue
Abstract 4370649: AI-Generated Semiautomated Echocardiographic-Derived Measurements Show Strong Agreement with CT for Tricuspid Annular Sizing
Background: Accurate tricuspid annular sizing is essential for procedural planning in transcatheter tricuspid valve intervention (TTVI). While contrast-enhanced, ECG-gated cardiac...
Abstract 4364333: Circulatory Support Devices in ST-Elevation MI Cardiogenic Shock Patients: Real-World Outcomes from Nationwide Inpatient Sample
Background: Recent guidelines for ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS) support the use of impeller percutaneous endovascular devices (PE...
Abstract 4371069: Adult Congenital Heart Disease and Atrial Fibrillation: A Double Burden on Cardiovascular Outcomes
Background: With 97% of congenital heart disease (CHD) patients now reaching adulthood, the risk of cardiovascular disease, including atrial fibrillation (AF), is higher compared t...
Abstract Sun603: Racial/Ethnic Disparities in Post-Arrest Cardiac Procedures for Out-of-Hospital Cardiac Arrest
Effective post-arrest care interventions are important components of the out-of-hospital cardiac arrest (OHCA) chain of survival. These can include echocardiography to identify potential cardiac etiol...
Abstract 4367850: In Vitro Investigation of the Pathophysiological Mechanisms Underlying Severe Cardiomyopathic Phenotypes Associated with Noonan Syndrome with Multiple Lentigines
Background: RASopathy-associated cardiomyopathy (RAS-CMP) is thought to involve abnormalities in cardiomyocyte differentiation and maturation. In our previous work, we identified t...
Abstract 4363341: Troponin Testing Trends in US Emergency Departments
Introduction: Little is known regarding recent temporal trends in troponin testing in US EDs. While insufficient testing risks overlooking MIs, excessive testing may contribute to...
Abstract 4358978: Dab2 Protects Endothelial Function and Promotes Atheroma Regression
Introduction: Endothelial cell dysfunction causes recruitment of inflammatory cells to the intima, initiating atheromatous plaque build-up. Atherosclerosis underlies myocardial inf...
Abstract 4364499: Performance of the Diabetes Outcomes Model in the United States (DOMUS) in a Large, Contemporary US Claims Dataset
Objectives: The Diabetes Outcomes Model in the US (DOMUS) was developed using 13 years (2005–2017) of data from Kaiser Permanente Northern California to project health outcomes and...
Abstract 4369827: Fibrillar Collagen Enrichment in Reprogrammed Pacemaker Cells Promotes Self-Organized, 3D Tissue-Like Models of the Sinoatrial Node
Introduction: The sinoatrial node (SAN) is a compact structure with rich extracellular matrix (ECM) with a high content of fibrillar collagen. We have previously demonstrated repro...
Abstract 4345218: Religious Beliefs Shape Self-Care among African Immigrant Adults with Hypertension and Diabetes
Background: Self-care behaviors (e.g., medication adherence) are key components of chronic hypertension and diabetes management. Many factors influence chronic disease management,...
Abstract 4367912: Safety and Outcomes of Class Ic Antiarrhythmic Use in Post-PCI Patients With New-Onset Atrial Fibrillation: A Nationwide Cohort Study.
Background: After percutaneous coronary intervention (PCI), newly-diagnosed atrial fibrillation (AF) poses a dual threat of thrombo-embolism and arrhythmic complications. Because C...
Abstract 4343394: Fulminant Eosinophilic Myocarditis in the Setting of DRESS Syndrome: A Case Report
Introduction: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe hypersensitivity reaction characterized by rash, fevers, eosinophilia and multi-org...
Abstract 4365971: Estrogen receptor alpha inhibits right ventricle cardiomyocyte NLRP3 inflammasome activation and restores right ventricular contractile function in low estrogen states
Background: The NLRP3 inflammasome is implicated in right ventricular (RV) dysfunction, particularly in low endogenous estrogen states found in males and postmenopausal females. We...
Abstract 4362224: Enhancing Mobility in Mechanical Support: A Retrospective Analysis of Axillary IABP Use
Introduction/Background: The axillary approach for intra-aortic balloon pump (IABP) placement offers an alternative to femoral access, with the advantage of preserving mobility dur...
Abstract 4366468: The Novel ErbB4 Agonist JK07 Modulates Gene Expression in Key Cardiac Cells. Insights from Single-Nuclei Transcriptomics in a Murine Heart Failure Model
Background: Heart failure (HF) involves complex interactions among cardiac cell types that drive disease progression. The neuregulin (NRG-1)/ErbB pathway is critical for cardiac re...
Abstract 4366850: Concomitant Infection in Cardiogenic Shock: Hospitalization Outcomes and Temporary Mechanical Circulatory Support Usage
Background: Cardiogenic shock (CS) is a condition in which cardiac dysfunction results in extensive hypoperfusion. While CS alone is life-threatening, it can be further exacerbated...
Abstract 4366587: Chronotherapy in Hypertension: A Meta-Analysis of the Cardiovascular Effects of Bedtime Versus Morning Antihypertensive Administration
Introduction/Background: With the prevalence of cardiovascular comorbidities in the current era, anti-hypertensive therapy has become a mainstay in clinical practice. However, the...
Abstract 4373253: Exposure to Fine Particulate Matter and Risk of Ventricular High-Rate Events in Patients with Cardiac Implantable Electronic Devices
Background: Subclinical arrhythmias such as atrial high-rate episodes (AHREs) and ventricular high-rate episodes (VHREs), detected by cardiac implantable electronic devices (CIEDs)...
Abstract 4364754: Prevalence of Non-Coronary Incidental Findings Identified on CT Coronary Artery Calcium Scans Performed on Patients Enrolled in the CorCal Study. Do we need to keep track of them?
Background: Coronary Artery Calcium CT scans provide a coronary artery calcium score that may be very useful in ascertaining a patient’s future cardiovascular risk. However, beside...
Abstract Sun607: The impact of safety net hospital status on survival among in-hospital cardiac arrest patients in a US registry
Background: Safety net hospitals (SNH) are a vital part of the US health care system, providing care to many of the most vulnerable patients who may have limited access to care. Th...
Abstract 4344032: Lp(a) is Associated with Coronary Inflammation in People with HIV with Undetectable HIV RNA
Background: People with HIV (PWH) remain at elevated risk for cardiovascular disease despite control of traditional risk factors and effective antiretroviral therapy. Vascular infl...
Abstract 4363308: Cerebral blood flow, Hemodynamics, Brain Injury and Association With Neurodevelopmental Outcome in Single Ventricle Patients After Fontan: A Pilot Study Utilizing Classification and Regression Tree (CART) Analysis
Background: We have previously demonstrated that single ventricle patients (pts) who have undergone the Fontan are known to exhibit brain injury (BI) and abnormalities in cerebral...
Abstract 4371025: Healthcare Expenditure on Cardiovascular-Kidney-Metabolic Health in Young Adults Aged 20 to 44 from 2010 to 2019
Background: Cardiovascular-kidney-metabolic (CKM) syndrome comprises interconnected conditions such as heart disease, kidney disease, diabetes, and obesity. These conditions often...
Abstract 4366248: GJA1 Internal Translation Regulates Acute Exercise-Mediated Cardiac Preconditioning
Regular physical activity is critical to maintain cardiovascular health. Endurance exercise reduces ischemic injury in the heart. Both ischemic preconditioning (IPC), and acute exercise preconditionin...
Abstract 4370874: A Suppression-and-Replacement Platform Identifies Pathogenic Variants in the <i>LMNA-</i> Encoded Lamin A/C Ig-Like Domain as Drivers of Nuclear Distortion and Aggregation
Background: Pathogenic variants in LMNA -encoded lamin A/C cause a genetic cardiomyopathy marked by conduction disease, atrial and ventricul...