Circulation
Articles in this Issue
Abstract 4370381: Intersecting Challenges: Clinical and Economic Outcomes of Heart Failure in Patients Undergoing CAR-T Therapy
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a breakthrough treatment for refractory hematologic malignancies. However, its cardiac risks and hemod...
Abstract 4365195: Temporary Atrial Pacing to Lower Left Ventricular Filling Pressures in Restrictive Cardiomyopathy: A Case Report
Introduction: An 85-year-old man presented to the hospital with acute on chronic diastolic heart failure secondary to transthyretin cardiac amyloidosis. He has a known history of g...
Abstract 4365683: Mapping the Myocardial Amyloid Burden in Transthyretin Cardiomyopathy: A Large-Scale Study Using Cardiac Magnetic Resonance and Extracellular Volume in 1,400 Patients
Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive disease driven by amyloid accumulation in the myocardial extracellular space. CMR-derived extracellular...
Abstract 4370885: Outcomes of Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes and Heart Failure with Preserved Ejection Fraction: A Retrospective Cohort Analysis
Background: Semaglutide, a GLP-1 receptor agonist, has demonstrated benefit in patients with heart failure with preserved ejection fraction (HFpEF). Tirzepatide, a dual GIP/GLP-1 r...
Abstract 4360714: Insights from RNA-Sequencing and Mendelian Randomization in Endometriosis and Cerebral Small Vessel Disease
Background: Endometriosis increases risk of cognitive impairment, coagulopathy, and ischemic and hemorrhagic stroke. Endometriosis affects ~10% of reproductive-age women globally,...
Abstract 4363477: The Paradoxical Embolus – A Case of Simultaneous Massive PE and RCA STEMI in the Setting of Provoked Venous Thromboembolism and Patent Foramen Ovale
Case Presentation: A 53-year-old woman with a history of recent left patellar fracture and tobacco use presented with sudden-onset chest pain and shortness of breath. ECG showed ST...
Abstract 4367416: GLP-1 Receptor Agonists and Mortality Outcomes in Patients with Left Ventricular Assist Devices: A Propensity-Matched Cohort Study from the TriNetX Global Network
Background: Patients with left ventricular assist devices (LVADs) experience high mortality and infection-related complications. While Glucagon-like peptide-1 receptor agonists (GL...
Abstract 4367627: Catastrophic Antiphospholipid Syndrome Mimicking Acute Coronary Syndrome: A Diagnostic Challenge with Critical Clinical Implications
Case Description: A 66-year-old male with a history of non-obstructive coronary artery disease [Image 1], unprovoked pulmonary embolism, hypertension, and diastolic heart failure p...
Abstract 4343242: CXCL1 and CXCL2 act downstream to ATF6 and GRP78 in hypoxia-induced retinal neovascularization
Background: Retinal neovascularization is a significant contributor of vision loss. One of the chemokines found to be elevated in the vitreous samples of diabetic retinopathy patie...
Abstract 4347061: Impact of Preexisting Atrial Fibrillation on Mortality and Cardiovascular Outcomes in Kidney Transplant Recipients
Background: Atrial fibrillation (AFib) is common in kidney transplant recipients and may adversely affect outcomes. In the general population, AFib increases thromboembolism, bleed...
Abstract 4366888: Implanted Vagus Nerve Stimulators Show Reduced Risk of Developing Atrial Fibrillation and Supraventricular Tachycardia
Introduction: Implanted vagus nerve stimulators (VNS) have become an established therapy for treatment-resistant epilepsy and major depressive disorder (MDD), and the scope of its...
Abstract 4373036: Comparative Evaluation of US- and China-developed Large Language Models for Bilingual Coronary Heart Disease Patient Education
Background: Coronary heart disease (CHD) remains the leading global cause of mortality and imposes substantial clinical and socioeconomic burdens. Patient education significantly i...
Abstract 4365717: Novel Biomarkers of Tricuspid Valve regurgitation (TR). Insights from a novel and minimally invasive large-animal model of TR
Introduction: Tricuspid regurgitation (TR) contributes to severe cardiovascular complications by causing atrial and ventricular dilation, retrograde blood flow, and abnormal cardia...
Abstract 4352129: Triglyceride Lowering with Pemafibrate to Reduce Fibrinogen - PEMA-TAS study -
Background: Hypertriglyceridemia is associated with an increased risk of adverse cardiovascular outcomes in patients with coronary artery disease (CAD). Although pemafibrate is eff...
Abstract 4368960: High-Intensity Statin Therapy Improves Outcomes Even After LDL-C Goal Achievement in Chronic Coronary Syndrome
Introduction: Current guidelines recommend a "treat to target" approach for lipid-lowering therapy in patients with chronic coronary syndrome (CCS), achieving the low-density lipop...
Abstract 4359204: Repeated Exposure to Tobacco Smoke/Aerosol Reduces Myocardial Tissue Preservation after Subsequent Acute Myocardial Infarction in Rats
Background: Tobacco products, including combustible cigarettes and e-cigarettes (e-cigs), cause a range of adverse cardiovascular effects, involving an increased incidence of myoca...
Abstract 4369397: <u>Uncovering the Role of T-Cell and Fibroblast Crosstalk in Immunotherapy-Induced Myocarditis</u>
Introduction: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate immune cells against tumor cells but can cause immune related adverse events such as myoca...
Abstract 4364485: Physics-Based Engineering for Vascular Shunts: Optimizing Performance, Blood Flow, and Clot Prevention
Background: The modified Blalock-Taussig-Thomas shunt (mBTTS) is a critical palliative procedure for infants with single-ventricle physiology, but thrombosis-related occlusion affe...
Abstract 4366927: Cost Effectiveness of Intravascular Use for Lower Extremity Deep Venous Procedures in Real World Practice
Introduction: The use of intravascular ultrasound (IVUS) to guide lower extremity deep venous stent placement is associated with improved identification of the degree of maximal ve...
Abstract 4363330: 4D Cardiac Magnetic Resonance Identifies Differences in Regional Strain Patterns Among Pediatric Heart Transplant Patients with Acute Rejection or Cardiac Allograft Vasculopathy
Background: Acute rejection (AR) and cardiac allograft vasculopathy (CAV) are leading causes of morbidity and mortality after pediatric heart transplant (PHT). Cardiac catheterizat...
Abstract 4362533: Burden of coronary artery disease in cryptogenic ischemic stroke patients aged ≥50 years: A multimodality-imaging study
Background/Purpose: Cryptogenic stroke (CS) is defined as an ischemic stroke with no identifiable cause. We investigate the burden of obstructive and non-obstructive coronary arter...
Abstract 4370903: Association Between Meeting Physical Activity Time-Intensity Guidelines and Calf Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Artery Disease
Purposes: We determined whether meeting the 2018 physical activity time-intensity guidelines was associated with better microvascular function, assessed by calf muscle oxygen satur...
Abstract Sat601: Temporal Changes in Naloxone Recommendation in Out-of-Hospital Cardiac Arrest: A Review of EMS State Protocols across the United States
Background: Naloxone administration has recently been associated with increased survival to hospital discharge for survivors of out-of-hospital cardiac arrest. However, this study...
Abstract 4370811: Domains of School Readiness in Children Ages 3 to 5 Years Born With and Without Heart Disease: A Study From the 2022-2023 National Survey of Children’s Health
Background: Children born with heart disease (HD) face academic challenges due to associated physical, neurodevelopmental, cognitive, psychosocial delays that begin in early infanc...
Abstract 4361931: Metabolic pathways differ in Black adults with heart failure with and without diabetes
Background: Black adults experience disproportionately high rates of heart failure (HF) and type 2 diabetes (DM). Comorbid HF and DM pose unique clinical challenges and are accompa...