Circulation
Articles in this Issue
Abstract 4363105: Glucose Homeostasis Measured By Continuous Glucose Monitor Is Associated With Cognitive Function In The Multi-Ethnic Study of Atherosclerosis
Background: Cardiometabolic disorders are a major contributor to cognitive decline and Alzheimer’s disease and related dementias; yet, gaps remain in our understanding of glucose h...
Abstract 4370902: Sex Differences in Latent Profiles of Hypertension-Mediated Organ Damage: A UK Biobank Analysis
Background: Hypertension-mediated organ damage (HMOD) can develop concurrently in the heart, the brain, the kidneys and the vasculature, yet most research still relies on counting...
Abstract 4371548: GLP-1 Receptor Agonists Use in Pregnant Women Reduce Adverse Maternal and Fetal Outcomes: A Meta-Analysis
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have recently gained prominence as both anti-diabetic medications and treatments for obesity in pregnancy. Never...
Abstract 4371570: Comparing the Safety and Efficacy of Direct Oral Anticoagulants versus Vitamin K Antagonists in Bioprosthetic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Background: Direct oral anticoagulants (DOACs) are efficient alternatives to vitamin K antagonists (VKAs). However, little is known about their efficacy and safety profile in patie...
Abstract 4361080: Daily Dietary Nutrients Predict Progression of Cardiovascular-Kidney-Metabolic Syndrome: A Machine Learning and SHAP Interpretation Study
Background: The Cardiovascular–Kidney–Metabolic (CKM) syndrome, recently proposed by the American Heart Association, underscores the interplay among metabolic, renal, and cardiovas...
Abstract 4341072: Psychological Factors, Health Behaviors, and Cardiovascular Disease Risk in Family Caregivers of Thai Older Adults with Dementia
Aims: Family caregivers of persons with dementia are at increased risk for cardiovascular disease (CVD), yet associated factors remain underexplored, particularly in Thailand’s rap...
Abstract 4345498: Acute MI Induced Papillary Muscle Rupture Causing Cardiogenic Shock Treated with Impella as A Bridge to Valve Replacement
Clinical Course: A 62-year-old male with a history of coronary artery disease presented with one month of intermittent chest pain which progressed to severe persistent chest pain....
Abstract 4347178: Late Presentation Myocardial Infarction With Dueling Mechanical Complications: Dynamic Left Ventricular Outflow Tract Obstruction (LVOTO) and Ventricular Septal Rupture (VSR)
Introduction: Post-myocardial infarction ventricular septal defect (MI-VSD) is a rare, often fatal complication of MI, regardless of treatment approach. Presentations vary from new...
Abstract 4364433: Systematic phenotyping, cause of death and genomics Analysis in Sudden Cardiac Arrest
Introduction: Sudden cardiac arrest (SCA) continues to have poor survival, with 90% of cases succumbing to sudden cardiac death (SCD). Despite international guidelines, high mortal...
Abstract 4366924: Beyond General HIV Risk: Insights on Antiretroviral Agents, Immune Status, and Cardiovascular Disease Progression in a Vulnerable Urban Cohort
Introduction: People living with Human Immunodeficiency Virus (HIV) have increased cardiovascular disease (CVD) risk, yet the specific contributions of antiretroviral therapy (ART)...
Abstract 4343730: Reference value range and clinical significance of fetal heart key parameters in early pregnancy
Objective: To evaluate the value of combined fetal heart V-angle (VSA), cardiothoracic ratio (CTR), whole heart spherical index (GSI) and axis of the heart (CAx) in predicting cong...
Abstract 4370000: Genetic Counseling Trends Amongst Cardiomyopathy Associated with Pregnancy
Background: Cardiomyopathy (CM)- including peripartum (PPCM) and other subtypes of dilated cardiomyopathy (DCM)- significantly contribute to maternal morbidity and mortality. Genet...
Abstract 4366936: Short-term Prognostic Value of Early Renal Microcirculatory Assessment Using Superb Microvascular Imaging in Acute Decompensated Heart Failure: A Prospective Study
Background: Renal hemodynamics plays a crucial role in the pathophysiology and clinical trajectory of acute decompensated heart failure (ADHF). Superb Microvascular Imaging (SMI),...
Abstract 4367835: Macrophage-Targeted Theranostic Photoactivation Drives Inflammation Resolution and Stabilization of Atherosclerotic Plaques through Autophagy, Efferocytosis, and TGF-β-mediated Fibrotic Replacement
Introduction: Atherosclerosis is fundamentally driven by chronic, unresolved inflammation within arterial plaques. Photoactivation, which employs light-activated agents to generate...
Abstract 4368540: A Spatially Resolved Transcriptomic Signature of Atherosclerotic Plaque Stabilization and Regression
Introduction: Major adverse cardiovascular events (MACE) in those with atherosclerotic cardiovascular disease (ASCVD) continues to be a leading contributor to death worldwide, driv...
Abstract 4369920: Wireless Battery-Free Continuous EKG Monitoring Platform with Therapeutic Stimulator Using Dual Recording-Stimulating Electrodes
Background: Heart-failure with preserved ejection fraction (HFpEF) now accounts for ~50% of heart-failure admissions and carries a 5-15% incidence of sustained ventricular tachycar...
Abstract 4347654: Trends in Stroke Mortality and Burden Due to High Blood Pressure: A Comparison of the U.S. and High Sociodemographic Index Countries
Background: Stroke remains a leading cause of death and disability globally. High blood pressure (BP), particularly elevated systolic levels, is a major modifiable risk factor for...
Abstract 4363999: Sex-Specific Cardiac Remodeling, Mitochondrial Dysfunction, and Transcriptomic Changes in Elderly Baboon Offspring Following Prenatal Synthetic Glucocorticoid Exposure
The theory of developmental origins of health and disease suggests prenatal stressors, like synthetic glucocorticoids (sGC) administered to enhance fetal lung maturity, may predispose offspring to car...
Abstract 4362667: Examination of ICU-Acquired Weakness in Patients with Acute Aortic Dissection
Background: Post-intensive care syndrome (PICS) encompasses cognitive, psychiatric, and physical impairments that may persist following ICU and hospital discharge. Despite its clin...
Abstract 4371287: Elevated Pulse Pressure Is Independently Associated With Increased Risk of Gastrointestinal Bleeding in Anticoagulated Atrial Fibrillation Patients
Background: Pulse pressure (PP), the difference between systolic and diastolic blood pressure, reflects arterial stiffness and vascular aging. Its role in predicting gastrointestin...
Abstract 4365011: Safety and Efficacy of Istaroxime in Acute Heart Failure Related Pre-Cardiogenic Shock: An Updated Systematic Review and Meta Analysis of Randomized Controlled Trials
Background: Acute heart failure (AHF) with pre-cardiogenic shock carries substantial morbidity and mortality. Istaroxime, a novel intravenous inotrope that enhances both cardiomyoc...
Abstract 4357489: Indirect Echocardiographic Markers of Procedural Success in Mitral Transcatheter Interventions: A Case Series
Introduction: Standard echocardiographic measures of mitral regurgitation (MR) severity, such as vena contracta width (VCW) and effective regurgitant orifice area (EROA), are often...
Abstract 4353865: Proteomics Discovery and Epicardial Adipose Tissue: PROMISE Clinical Trial Substudy
Background: Epicardial adipose tissue (EAT) is a metabolically active tissue. EAT volume and density (a marker of tissue inflammation), which can be quantified using cardiac comput...
Abstract 4373361: High-fat diet unmasks latent arrhythmogenic remodeling in Mc4r-knockout mice: Insights from a genetic model of obesity-induced atrial fibrillation
Background: While high-fat diet (HFD)-induced obesity is widely used to model obesity-associated atrial fibrillation (AF), the electrophysiological mechanisms in genetic obesity re...
Abstract Sun1101: Development of a Dedicated Campus Response Team to Standardize Resuscitation Care Across Inpatient and Outpatient Emergency Responses
Introduction: Academic medical centers frequently operate across expansive geographic areas including inpatient units, outpatient clinics, and office buildings. While hospital-base...