Circulation
Articles in this Issue
Abstract 4370376: Prevalence and Post-Discharge Outcomes of Acute Noncardiac Organ Failure among Non-Acute Myocardial Infarction Cardiogenic Shock: A Nationwide Cohort Analysis
Introduction: Noncardiac organ failure is a frequent complication in non–acute myocardial infarction (non-AMI) cardiogenic shock (CS), which accounts for a substantial proportion o...
Abstract 4365305: An Unusual Presentation of Cerebellar Stroke Following the Removal of Microaxial Flow Pump
Introduction: With the rise in Microaxial Flow Pump (MAFP) usage for acute myocardial infarction (AMI) related cardiogenic shock, early recognition of MAFP complications is critica...
Abstract 4369137: Elevated Coronary Angiography-Derived Index of Microvascular Resistance Predicts Poor Prognosis in Angina with Non-Obstructive Coronary Artery Disease
Background: Angina with non-obstructive coronary artery disease (ANOCA) prognosis requires improved prediction tools. The prognostic role of coronary angiography-derived index of m...
Abstract 4373072: Evaluating the Outcomes and Complications of Implantable Cardioverter Defibrillator Therapy in Hypertrophic Cardiomyopathy
Background: Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death in patients with hypertrophic cardiomyopathy (HCM). However, ICD implant...
Abstract 4366799: Genetic and Brain MRI Markers Reveal Cardiovascular Burden Across Brain Disorders
Background: Cardiovascular disease (CVD) impairs not only cardiac function but also induces structural and functional changes in the brain. However, the specific brain regions most...
Abstract 4370544: Novel Strategies for Inferential Error Management in Reused Clinical Datasets
Introduction: The use of publicly available datasets and large-scale registries, such as the Society of Thoracic Surgeons (STS) National Databases and the Medicare database, has re...
Abstract 4371331: Redlining, Segregation, and Disparities in Heart Health: Structural Racism as a Driver of Adverse Cardiovascular Outcomes
Background: Systemic barriers such as residential segregation and redlining exacerbate cardiovascular health disparities by restricting access to healthcare, socioeconomic opportun...
Abstract 4343009: Development and Validation of an Echocardiographic Nomogram for Identifying Cardiac Amyloidosis in Patients with Left Ventricular Hypertrophy
Backgraound: Echocardiography is the principal non-invasive imaging modality for screening cardiac amyloidosis. This study aimed to establish a cohort of CA-associated left ventric...
Abstract 4357158: Neutrophil Elastase: A Novel Therapeutic Target for Heart Failure with Preserved Ejection Fraction
Introduction: Heart failure with preserved ejection fraction (HFpEF) is a multifarious syndrome, accounting for over half of clinical heart failure patients. Neutrophil elastase (N...
Abstract 4360368: <u>SYSTEMIC INFLAMMATION AND CARDIOVASCULAR EVENTS AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE</u>
Background: Patients with chronic kidney disease (CKD) present high risk of new or recurrent cardiovascular events despite traditional risk factor management....
Abstract Sun605: Gender Modifies The Survival Benefit of Cardiopulmonary Resuscitation after Out-of-Hospital Cardiac Arrest: Multicenter, Cohort Study, The SOS-KANTO 2017 Study
Background: cardiopulmonary resuscitation (CPR) is crucial for survival in patients with out-of-hospital cardiac arrest (OHCA). Therefore, it is imperative to study factors that ma...
Abstract 4347921: Long-Term Survival in Pediatric Heart Transplantation: A PHTS-SRTR Linkage Study
BACKGROUND: There is a growing population of adult survivors after pediatric heart transplantation (HTx). Little is known about long-term outcomes, particularly after transition to...
Abstract Sat501: Retention of Practical and Cognitive Skills in Advanced Life Support Among Professionals in Public Hospitals of Chile
Background: Despite advances in education and resuscitation science, adult cardiac arrest survival rates remain suboptimal. The American Heart Association® states that training pro...
Abstract 4357245: Sex-Based Troponin Kinetics from Symptom Onset In Suspected Acute Coronary Syndrome Patients Undergoing Coronary Angiography
Background: Cardiac troponin I (cTnI) is a critical diagnostic biomarker in evaluating acute coronary syndrome (ACS), particularly in non-ST-segment elevation (NSTE). Serial cTnIs...
Abstract 4368865: Ly6C-Targeted LNP Delivery of CAR-ABCA1 mRNA Reprograms Macrophages for Enhanced Efferocytosis and Cholesterol Efflux in Atherosclerosis
Introduction: Atherosclerosis (AS) is a chronic inflammatory disease characterized by lipid accumulation and defective clearance of apoptotic cells in plaques. Traditional LDL-C-lo...
Abstract 4369984: Collateral Injury of the Conduction System During Catheter Ablation of Ventricular Tachycardia: Incidence and Impact on Outcome
Background: Patients with recurrent ventricular tachycardia (VT) undergoing catheter ablation have risk of collateral injury to the conduction system (CICS), particularly if the ta...
Abstract 4364515: A Systems-Level Intervention Improved Alignment of Initial Hypertension Pharmacotherapy with Clinical Practice Guidelines at a Veterans Affairs Medical Center
Introduction: ACC/AHA clinical practice guidelines recommend initial dual-agent pharmacotherapy for Stage II HTN (BP >140/90), with growing evidence favoring single-pill combina...
Abstract 4368425: Comparison of Self-Expandable and Balloon-Expandable Valves in Conduction Outcomes Following TAVR: A Meta-Analysis of 35,946 Patients
Background: Conduction disturbances, including high-degree atrioventricular block (HAVB) and the need for permanent pacemaker implantation (PPI), have been reported following trans...
Abstract 4372722: Unveiling S1PR1 Internalization in Left-Sided Trabecular development
Introduction: Congenital heart disease (CHD) is the most common birth defect and a major cause of neonatal mortality. Over half of CHD cases remain genetically unexplained. The lip...
Abstract 4370029: Imaging Markers of Myocardial Fibrosis in Mitral Valve Prolapse Across Stages of Mitral Regurgitation Severity
Background: Mitral valve prolapse (MVP) is associated with mitral regurgitation (MR), which can lead to adverse cardiac remodelling due to volume overload. In addition, mechanical...
Abstract 4368942: Electronegative VLDL Drives Maturity-Dependent Cellular Dysfunction on Human Cardiomyocytes
Background: Lipid overload-induced cardiomyocyte dysfunction is a key contributor to heart failure and other cardiometabolic diseases. Very-low-density lipoprotein (VLDL), the main...
Abstract 4369528: Macrophage Cu Transporter CTR1 deficiency Impairs Post-Ischemic Revascularization by Promoting cGAS-STNG Pathway and Pro-Inflammatory Macrophage Phenotypes
Background: Macrophage plays a critical role in promoting perfusion recovery and revascularization through anti-inflammatory polarization and metabolic reprogramming, required for...
Abstract 4366982: Sex and Racial Discordance in Referrals for Coronary Artery Calcium Screening at a Large Urban Center
Background: Coronary artery calcium(CAC) scoring is a non-invasive tool for detecting subclinical atherosclerosis. In 2022, RUSH University Medical Center launched a low-cost CAC s...
Abstract 4366746: Association of Body Size and Shape Metrics with Atherosclerotic Cardiovascular Disease and Mortality: Ethnic Differences in a Nationally Representative Cohort of U.S. Adults
Background: BMI is widely used to assess adiposity and cardiometabolic risk, yet its utility varies by race/ethnicity. Alternative indices such as Body Roundness Index (BRI) and A...
Abstract 4339399: Incidence and predictors of Monomorphic Ventricular Tachycardia in Three Major Subcutaneous ICD Trials
Background: The subcutaneous ICD (S-ICD) is currently contraindicated for patients (pts) who have monomorphic ventricular tachycardia (MVT) that can be terminated by anti-tachycard...