Circulation
Articles in this Issue
Abstract 4358501: Sex Differential Association of High-Density Lipoprotein Particle Concentration and Atherosclerotic Cardiovascular Disease in Diabetes
Background: Women with diabetes have a 50% higher risk of ASCVD than men. HDL particle concentration (HDL-p) is inversely associated with ASCVD risk. Previously, we showed that wom...
Abstract 4354338: Educational Disadvantage as a Social Determinant of Health and Its Impact on Maternal Cardiovascular Outcomes in the Fourth Trimester: A Retrospective Propensity-Matched Cohort Study (2008–2023)
Background: Education and literacy are key components of the social determinants of health (SDOH) that may influence maternal cardiovascular health, particularly during the vulnera...
Abstract 4365880: Antibody-conjugated SIS3-loaded polymeric nanoparticles alleviate acute myocardial infarction- and pressure overload-induced cardiac fibrosis by targeting myofibroblasts
Background: Pathological cardiac fibrosis arising from acute/chronic myocardial injury drives ventricular remodeling, functional impairment, and elevated mortality through mechanis...
Abstract 4371590: No-Touch Saphenous Vein Grafting Reduce Occlusion Risk but Increase Leg Wound Complications in Coronary Artery Bypass Grafts: A Meta-Analysis
Introduction: Saphenous vein graft (SVG) failure remains a key limitation in coronary artery bypass grafting (CABG). The no-touch harvesting technique aims to improve graft durabil...
Abstract 4366199: Mitochondrial Transfer between Stromal Cells and Macrophages in Atherosclerotic Plaques Regulates Macrophage Phenotype Conversion toward the M2 Subtype
Background: Intercellular mitochondrial transfer has been documented to modulate cellular function in multiple disease contexts. Nevertheless, its occurrence and pathophysiological...
Abstract 4338191: Outcomes of Infective Endocarditis in Congenital Heart Disease Across Age Groups: A Systematic Review and Meta-Analysis
Background: Infective endocarditis (IE) remains a severe condition with high morbidity and mortality. Patients with congenital heart disease (CHD) are especially vulnerable due to...
Abstract 4342051: Fatty Degeneration of Nonhemorrhagic Myocardial Infarction: a Longitudinal PET/MRI Study with Histological Validation
Background: Fatty degeneration of infarcted myocardium, also known as lipomatous metaplasia (LM), is a highly prevalent phenomenon linked with high incidence of major adverse cardi...
Abstract 4365845: Low Rates Of Escalation Of Lipid Lowering Therapy Amongst Atherosclerotic Cardiovascular Disease Patients With Uncontrolled LDL-C
Background: In patients with atherosclerotic cardiovascular disease (ASCVD), guidelines recommend a reduction in low-density lipoprotein cholesterol (LDL-C) to target levels with s...
Abstract 4368444: Triglyceride in different ApoB-containing lipoproteins and risk of coronary artery disease: particle type matters
Introduction: Plasma triglyceride (TG), mostly embedded in apoB-containing particle (apoB-P), has been proposed as a potential residual risk factor for atherosclerotic cardiovascul...
Abstract 4369978: Gestational Diabetes Mellitus Is Associated with Increased Fetal Interventricular Septal Thickness and Impaired Cardiac Function in the Third Trimester
Introduction: Gestational diabetes mellitus is increasingly recognized as a risk factor for adverse fetal cardiovascular remodeling. Hyperglycemia during pregnancy may lead to alte...
Abstract 4355586: Enhancing the PREVENT Equation with a Polygenic Risk Score: Clinical Utility Evaluation
Introduction: The PREVENT risk prediction equations for primary prevention of atherosclerotic cardiovascular disease (ASCVD) was developed to overcome limitations of prior ACVD equ...
Abstract 4360118: Underestimation of Cardiovascular Risk in South Asians: A Systematic Review of Global Risk Prediction Tools (2014–2024)
Background: South Asians face a disproportionately high burden of atherosclerotic cardiovascular disease (ASCVD), often presenting at younger ages and with fewer traditional risk f...
Abstract 4369519: Establishing functional benchmarks and pharmacological readiness of Mantarray-Engineered Heart Tissues across multiple hiPSC-derived cardiomyocyte lines
Human induced pluripotent stem cell (hiPSC)-derived engineered heart tissues (EHTs) have significant potential for advancing our understanding of cardiac physiology, modeling diseases, screening drugs...
Abstract 4365668: Diagnostic Performance of Cardiac Magnetic Resonance Imaging versus Fluorodeoxyglucose Positron Emission Tomography for Cardiac Sarcoidosis: A Systematic Review and Meta-Analysis
Background: Cardiac sarcoidosis (CS) is a rare, but potentially life-threatening manifestation of systemic sarcoidosis. While both cardiac magnetic resonance imaging (CMRI) and flu...
Abstract 4339114: Hyperglycemic adipocyte-derived exosomes aggravate oxidative stress, lipid peroxidation and mitochondrial dysfunction of brain microvascular endothelial cells in ischemic stroke
Background: Type 2 Diabetes Mellitus, a risk factor for ischemic stroke (IS), is characterized by hyperglycemia and adipose tissue (AT) dysfunction. AT excert endocrine and paracri...
Abstract 4364145: Social Risk Factors and Advanced Cardiovascular-Kidney-Metabolic (CKM) Syndrome in U.S. Adults: Evidence from NHANES 2005–2018
Introduction: Cardiovascular-Kidney-Metabolic (CKM) Syndrome is a growing public health concern linked to increased morbidity and mortality. The sociopolitical and economic environ...
Abstract 4335891: Disparities in Blood Pressure Readings Among Sheltered Women Experiencing Homelessness: Insights from a Student-Run Free Clinic
Background: Hypertension disproportionately affects marginalized populations, including women experiencing homelessness (WEH), who face barriers to healthcare and chronic disease m...
Abstract 4369410: Angiotensin Converting Enzyme Gene Polymorphisms (ACE-I/D) Do Not Predict Exercise-Induced Cardiac Remodeling or Performance in Adolescent Male Athletes
Background: Angiotensin Converting Enzyme (ACE) Insertion/Deletion (I/D) polymorphisms have been extensively studied to determine their contributions to athletic power, strength an...
Abstract 4365862: Dual Burden of Cancer and Stroke: Long-term Cardiovascular Risk in Survivors of Post-cancer Stroke
Background: Cancer survivors are at increased risk for cardiovascular disease (CVD), yet the long-term impact of new-onset stroke occurring after cancer diagnosis remains poorly ch...
Abstract 4369259: Cardiovascular Health Characterization Using Life’s Essential 8 Score in Perimenopausal Women: An NHANES Analysis
Background: An accelerated increase in cardiometabolic risk has been observed in women during the perimenopausal period, likely due to hormonal fluctuations that affect cardiovascu...
Abstract 4362684: Trends and Disparities in Aortic Dissection Mortality in the United States: A Retrospective Analysis
Background: Aortic dissection (AD) is a potentially life-threatening cardiovascular condition associated with significant morbidity, and mortality in adults aged >25 years. We a...
Abstract 4366209: Left Atrial Appendage Occlusion vs Anticoagulation Following Atrial Fibrillation Ablation: A Propensity-Matched Comparative Outcomes Study
Background: Anticoagulation remains the standard of care following catheter ablation for atrial fibrillation (AF). However, the role of left atrial appendage occlusion (LAAO) as an...
Abstract 4370980: Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk
Background: Vascular smooth muscle cells (SMC) contribute to heritable coronary artery disease (CAD) risk and undergo complex cell state transitions to multiple disease related phe...
Abstract 4339586: Aspirin Versus P2Y12 Inhibitors as Monotherapy for Secondary Prevention in Coronary Artery Disease: A Systematic Review and Meta-analysis
Background: Coronary artery disease (CAD) is a leading cause of global morbidity and mortality. While acetylsalicylic acid (ASA) has long been the cornerstone of antiplatelet thera...
Abstract 4367184: Association of natriuretic peptide concentration with lifetime risk of heart failure in adults with diabetes mellitus: a pooled cohort analysis
Background: Natriruetic peptide (NP) screening is recommended for HF prevention in diabetes mellitus (DM), with NT-proBNP >125 pg/mL considered abnormal. However, evidence suppo...