Circulation
Articles in this Issue
Abstract 4365827: Structural and Load-Dependent Arterial Stiffness Mechanisms and Sleep-Disordered Breathing: The Multi-Ethnic Study of Atherosclerosis.
Background: Obstructive sleep apnea (OSA) is associated with increased arterial stiffness and adverse cardiovascular outcomes. Structural and load-dependent components reflect stif...
Abstract 4363984: The Andes Cardiac Magnetic Resonance Follow-up of a Fontan Cohort
Introduction/Background - Research Questions/Hypothesis: There is a notable lack of robust evidence regarding imaging follow-up in Fontan patients from resource-limited settings, w...
Abstract 4369294: Estimated Lifetime Benefits of Finerenone on Cardiorenal Morbidity and Mortality in Patients with Type 2 Diabetes and Chronic Kidney Disease
Introduction: Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improves cardiovascular and kidney outcomes in people with type 2 diabetes and chronic kidney disea...
Abstract 4363100: Temporal Trends in Cardiovascular Mortality Co Occurring With Hematological Malignancies Among US Adults Aged 25 to 85 From 1999 to 2023
Introduction: Adults with hematological malignancies remain at elevated risk of cardiovascular death. Understanding national trends and disparities may help inform cardio-oncology...
Abstract 4357987: Cardioprotective Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Patients undergoing Ventricular Tachycardia (VT) Ablation: A Propensity-Matched Cohort Study
Background: Cardiovascular disease is one of the leading causes of death in patients with type 2 diabetes mellitus (T2DM). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have p...
Abstract Sat1108: Does Out-of-hospital Cardiac Arrest Survival Differ by EMS Agency Type in the US? Insights from the CARES Registry
Background: There are limited data on whether out-of-hospital cardiac arrest (OHCA) survival differs by EMS agency type in the U.S....
Abstract 4367174: Left Ventricular Thrombus and Occluded Coronary Artery in a Patient with JAK2 V617F Mutation
Background: Left ventricular thrombus (LVT) is often associated with anterior myocardial infarction (MI) and reduced ejection fraction (EF). However, it could be present in patient...
Abstract 4368185: Serum Transthyretin Levels at Day 28 are Associated with Cardiovascular Outcomes: Insights From the ATTRibute-CM Study
Introduction: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) typically have low serum transthyretin (sTTR) levels, worsening heart failure, and increased mortality. A...
Abstract 4367009: Characterizing Conventional and Expanded Adverse Childhood Experiences’ Effect on Mental Health in Black Men with Unideal Cardiovascular Health: Black Impact
Objective: Adverse Childhood Experiences (ACEs) are traumatic exposures such as abuse, neglect, and household challenges that occur in childhood, and are associated with numerous p...
Abstract 4370389: Deciphering the source of alkaline phosphatase activity in ectopic vascular calcification
Background: Tissue-nonspecific alkaline phosphatase (TNAP) has emerged as a key contributor to vascular calcification. Prior studies have linked elevated plasma TNAP levels to incr...
Abstract 4371808: Insurance-Related Disparities in Antihypertensive Treatment Among U.S. Adults: A Decade-Long NHANES Analysis (2013–2022)
Background: Hypertension remains the most prevalent modifiable risk factor for cardiovascular disease. Although national access to care has improved, disparities in antihypertensiv...
Abstract 4343411: Coronary Microvascular Disease Modulates Long-Term Outcomes in Myocardial Infarction with Non-Obstructive Coronary Arteries
Background: Coronary microvascular dysfunction (CMD) is a common cause of angina with non-obstructive coronary arteries (ANOCA), but its role in patients with a history of myocardi...
Abstract 4359825: Cardiovascular Disease Predictive Models with Only Social Determinants and Behavioral Factors may be as Predictive as Traditional Risk Scores
Background: This study aimed to develop cardiovascular (CVD) predictive models using only social, environmental, and behavioral drivers of health. Traditional CVD risk scores incor...
Abstract 4367381: Among Older Adults With Atrial Fibrillation, First Anticoagulant Prescription Is Not Associated with Reduced Hazard of Ischemic Stroke but Is Associated with Increased Hazard of Major Bleeding: A Nationwide Study
Introduction: Sevferal trials have demonstrated that oral anticoagulation reduces ischemic stroke risk in patients with atrial fibrillation (AF), the most common cardiac arrythmia...
Abstract 4372833: Study on the Mechanism of Protocatechualdehyde in Improving Sepsis-Induced Cardiomyopathy by Targeting Mitochondrial ROS and Inhibiting the GSDMD/STING Pathway in Macrophage
Background: Sepsis-induced cardiomyopathy (SICM) is a major cause of high morbidity and mortality in septic patients. In SICM, macrophage infiltration and aberrant immune activatio...
Abstract 4367808: Age at Pulmonary Valve Replacement is not Associated with Reverse Right Ventricular Remodeling in Patients with Tetralogy of Fallot
Introduction: Pulmonary regurgitation and ensuing volume load in repaired tetralogy of Fallot (rTOF) leads to remodeling of the right ventricle (RV) and which has been associated w...
Abstract 4356951: Adverse Outcomes Following Atrial Fibrillation Ablation in Patients With Connective Tissue Disease: A Propensity-Matched Real-World Analysis
Background: Connective tissue diseases (CTDs) are systemic autoimmune disorders associated with elevated cardiovascular risk, including atrial fibrillation (AF). While catheter abl...
Abstract 4369233: Endothelial-specific Suppression of Canonical Wnt Signaling Promotes Fatty Acid Metabolism and Protects Against Endothelial Hyperpermeability
Introduction: Dysregulated endothelium contributes to the pathogenesis of cardiovascular disease. Endothelial cell (EC) metabolic pathways are pivotal regulators of inflammation an...
Abstract 4370263: Cost-Effectiveness of AI-Enabled Coronary Plaque Analysis for Management of Stable Coronary Artery Disease
Introduction: Recent clinical studies have established that non-calcified plaque in the coronary arteries plays a greater role in risk of myocardial infarction (MI) than calcified...
Abstract 4366828: Does Qualitative Coronary Artery Calcium on Prior Chest CT Add to Risk Stratification of Chest Pain in the Emergency Room?
Background: Chest pain patients with moderate elevations of high sensitivity troponins (i.e., between the 99th percentile and what is considered “positive”) benefit from additional...
Abstract 4364284: A Machine Learning-Derived Socio-Environmental Risk Score More Accurately Predicts Cardiovascular Events and Better Addresses Health Inequities than Social Deprivation Index
Introduction: The American Heart Association’s PREVENT equation now includes zip-code level Social Deprivation Index (SDI), highlighting the growing role of socio-environmental (SE...
Abstract 4370250: Regulatory Profiling of LMNA Identifies Therapeutic Targets for LMNA-Associated Dilated Cardiomyopathy
Introduction/Background: LMNA (encoding gene lamin A/C) cardiomyopathy is associated with high morbidity and mortality. LMNA loss-of-function variants frequently lead to dilated ca...
Abstract 4364909: Emotional Disorders: A Potential Bridge Connecting Oral Health and the Progression of Heart Failure
Background: Heart failure (HF) is impacted by non-traditional factors like emotional disorders(anxiety/depression). Oral health's link to cardiovascular disease is growing, with or...
Abstract 4347224: The Chinese Medicine Xinfuli Granules in Chronic Heart Failure with Reduced Ejection Fraction: A Single-Center, Randomized Controlled Trial
Objective: As an integral component of complementary and alternative medicine systems, Traditional Chinese Medicine (TCM) has presented novel therapeutic possibilities for the clin...
Abstract 4336717: A Case Report of Cardiac Tamponade due to Mycoplasma Pneumoniae-induced Pericarditis - A Rare Complication of a Commonly seen Bacterial Infection
Case Description: A 69-year-old female with rheumatoid arthritis (RA) on methotrexate, rituximab, and prednisone presented with pleuritic chest pain, fever and cough. Vitals were s...