Circulation
Articles in this Issue
Abstract 4359241: Cholesterol Management in US Individuals with ASCVD within the Family Heart Database <sup>®</sup> during 2022/23: Current State of Care and Opportunities for Improvement
Background: Individuals with atherosclerotic cardiovascular disease (ASCVD) have increased risk of recurrent events and need optimized low density lipoprotein-cholesterol (LDL-C) l...
Abstract 4369820: Role of an Electrophysiology Study in predicting Major Adverse Ventricular Arrhythmias and Related Events in patients with a Systemic Right Ventricle
Background: Patients with systemic right ventricle (sRV), including congenitally corrected transposition of great arteries (cc-TGA) and dextro-transposition of great arteries (d-TG...
Abstract 4367410: Association Between COVID-19 and In-Hospital Mortality in Patients with Peripheral Arterial Disease and Acute Limb Ischemia: Analysis of National Inpatient Sample (2020-2022)
Introduction: Peripheral arterial disease (PAD) complicated by acute limb ischemia (ALI) is a vascular emergency. The emergence of COVID-19, with its known prothrombotic effects, h...
Abstract 4367943: Fungal Pericarditis Masquerading as Sterile Effusion: A Case of Delayed Recognition
Background: Fungal pericarditis is rare, accounting for <1% of pericardial effusions. Up to 50% of cases occur in immunocompetent individuals. Overall, 30% of cases present with...
Abstract 4370915: Obesity and Potential Echocardiographic Predictors of Sudden Cardiac Death
Background: Obesity and HFpEF are associated with sudden cardiac death (SCD), independent of underlying coronary disease. Noninvasive markers of SCD risk for these patients are nee...
Abstract 4366987: Non Muscle Myosin IIC Density and Filament Length Increases in Neonatal Rat Ventricular Myocyte under Isoproterenol Stress
Background: Myh14, encoding non-muscle myosin IIC (NMIIC), is a proposed negative regulator of isoproterenol (ISO)-induced cardiac hypertrophy. ISO upregulated mRNA transcript leve...
Abstract 4370073: A Delayed Diagnosis of Anti-HMG-CoA Reductase Immune-Mediated Necrotizing Myopathy
Description of Case: A 62-year-old male with a past medical history of chronic kidney disease stage 4, hyperlipidemia, and lacunar stroke presented with a 1-month history of worsen...
Abstract 4358270: Sodium-Glucose Cotransporter-2 Inhibitor Use Is Associated with Improved Cognitive Outcomes in Older Heart Failure Patients: A Comparative Analysis Using Real-World Clinical Data
Background: Cognitive impairment is a frequent and debilitating comorbidity in older adults with heart failure (HF). Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve HF-r...
Abstract 4345914: Right Ventricular Role in Heart Failure of Mildly Symptomatic and Asymptomatic Patients with Obstructive Hypertrophic Cardiomyopathy
Background: Heart failure (HF) is the most common complication in patients with obstructive hypertrophic cardiomyopathy (oHCM), significantly impairing quality of life and prognosi...
Abstract 4344315: When Cardiac Hypertrophy Masks Fabry Disease: A Pathological and Genetic Diagnostic Challenge
Introduction: Fabry disease (FD), an X-linked lysosomal storage disorder, is caused by mutations in the GLA gene, leading to deficient alpha-galactosidase A activity and subsequent...
Abstract 4366910: Multicenter Model to Predict Right Heart Failure After HeartMate 3 Left Ventricular Assist Device Implantation
Background: Right heart failure (RHF) is a serious complication of durable HeartMate 3 (HM3) left ventricular assist device (LVAD) therapy. We aimed to evaluate the incidence, pred...
Abstract 4364734: Mapping the Gene Network Dysregulation in Ascending Aortic Aneurysm Reveals Candidate Therapeutic Targets
Introduction: Ascending aortic aneurysm is a complex multicellular disease with high mortality associated with both monogenic causes and sporadic disease. Known causative genes inc...
Abstract 4364113: Cardiorenal Protective Effects of Anti-diabetic Drugs in Early Stage Cardiovascular-Kidney-Metabolic Syndrome: A Multicenter, Time-Varying Analysis
Introduction: There is a lack of direct real-world comparisons of specific anti-diabetic agents (ADAs) concerning their cardiovascular and renal effects in the early stages of Card...
Abstract 4366164: Heart Failure-Associated SNPs Are Enriched in Estrogen-Related Receptor Binding Regions
Introduction: Estrogen-related receptors (ERRs) are nuclear receptors essential for postnatal cardiac maturation. Our recent studies have shown that ERRs are necessary for coordina...
Abstract 4364628: Relationship between heart function, fibrosis and AT <sub>1</sub> receptors in the heart and the kidneys of a mouse model of doxorubicin-induced cardiomyopathy
Introduction: Ivabradine (IVAB) is an effective heart-rate lowering drug used in patients with heart failure. However, its potential protective effect in the context of doxorubicin...
Abstract 4370676: Rising Burden of Hypertensive Emergency Hospitalizations in Young Adults: Insights from the National Inpatient Sample
Background: Hypertensive emergency burden in young adults is poorly characterized despite rising risk factors. We evaluated trends, characteristics, and mortality predictors in adu...
Abstract 4361550: A Dangerous Right Turn: Primary Right Heart Failure in Mechanically Ventilated Patients—-Prevalence, Inpatient Outcomes, and High Use of Advanced ICU Therapies— A Nationwide Analysis
Introduction: Invasive mechanical ventilation (IMV) is often required in critically ill patients. Primary right heart failure (RHF) is increasingly recognized in this population. S...
Abstract 4369879: Gender-Specific Differences in Large Vessel Occlusion Outcomes: A National Inpatient Sample Analysis
Background: Large vascular occlusion (LVO) strokes account for a significant proportion of ischemic strokes, with considerable morbidity and death. While sex-based differences in s...
Abstract 4364364: Incidence and Clinical Significance of Immune-mediated Myocarditis after Gene Replacement Therapy: a Systematic Reviewew and Meta-Analysis
Introduction: Although adeno-associated (AAV) gene-replacement therapy is a potential transformative therapy for severe genetic diseases, their cardiac-immunotoxicity may pose chal...
Abstract 4371149: Racial Disparities in Catheter Ablation for Atrial Fibrillation and Heart Failure
Introduction: Contemporary trial data and professional guidelines support a rhythm control strategy with catheter ablation for patients with comorbid atrial fibrillation (AF) and h...
Abstract 4372728: Adiposomal microRNAs Mediate Vascular Dysfunction in Obesity-Associated Type 2 Diabetes
Background: Adipose tissue-derived extracellular vesicles (adiposomes) are key mediators of intercellular communication and play a critical role in metabolic disease progression, i...
Abstract 4340531: Interleukin-1 Blockade in Patients With ST-Segment-Elevation Myocardial Infarction: a Pooled Analysis of Randomized Clinical Trials of Anakinra and Goflikicept
Background: STEMI triggers an intense inflammatory response and Interleukin-1 (IL-1) is associated with adverse cardiovascular outcomes, including heart failure (HF). IL-1 blockade...
Abstract 4367773: Predicting Peak Heart Rate from Resting 12-Lead ECGs in Patients Undergoing Stress Testing using Deep Learning
Introduction: Cardiovascular stress testing is crucial for the evaluation of ischemic cardiomyopathy and inducible arrhythmias. Inappropriate heart rate (HR) response during stress...
Abstract 4363693: Cutting Through Calcification: A Comparison of Laser and Orbital Atherectomy Using Pedal Access in Peripheral Artery Disease
Background: Atherectomy is widely used in treating peripheral artery disease (PAD), especially for heavily calcified femoropopliteal and tibial lesions. However, procedural risks r...
Abstract 4365527: Forkhead Box O3 is required for normal cardiac immune cell composition and protects from maladaptive right ventricle remodeling upon pressure overload and pulmonary hypertension
Introduction: The Forkhead box O (FOXO) transcription factor FOXO3 plays a pivotal role in longevity, as single nucleotide polymorphisms (SNPs) in FOXO3 are associated with healthy...