Circulation
Articles in this Issue
Abstract Sun608: Sex Differences in Sudden Cardiac Arrest During Endurance Races: Could Acceleration Variability Account for the Disparity?
Background: Men account for over 85% of Sudden Cardiac Arrest (SCA) occurring during sport activities. This over-representation persists even after adjusting for sports participati...
Abstract 4366880: Rates of Atrial Fibrillation and Atrial Flutter in Non-diabetic Obese Adult Patients on Tirzepatide
Introduction: Atrial fibrillation and atrial flutter are the most common types of cardiac arrhythmias and a leading cardiac cause of stroke. Obesity is one of the factors that has...
Abstract 4343024: Primary Sarcomatoid Carcinoma of the Pericardium: First Reported Case and a Complex Diagnostic and Therapeutic Challenge
Introduction: Sarcomatoid carcinoma is an aggressive, poorly differentiated malignancy with both epithelial and mesenchymal features. While previously described in the lungs, kidne...
Abstract 4369177: From Voltage to Velocity: Functional Insights via Integrated Unipolar–Bipolar Mapping
Background: Accurate delineation of the atrial substrate is critical to tailoring therapy for atrial fibrillation (AF). Although bipolar voltage (BV) mapping is widely used, its fu...
Abstract 4361068: Hypertrophic Cardiomyopathy in a Patient With <i>BAG3</i> -Associated Charcot-Marie-Tooth Disease: A Rare Cardiac Manifestation
Introduction: BAG3 pathogenic variants and Charcot-Marie-Tooth (CMT) have been linked with various cardiac conditions, but rarely hypertrophic cardiomyopathy (H...
Abstract 4358752: High Dietary Inflammatory Index, Not Total Calorie Intake, Predicts Cardiometabolic Mortality in Non-Obese U.S. Adults: NHANES 2007–2018
Background: The American Heart Association has emphasized the impact of dietary patterns on cardiometabolic health. Inflammation plays a central role in the pathogenesis of cardiom...
Abstract 4364377: An Integrative Strategy Combining Genetic, Proteomic, and Clinical Data Identifies Circulating WARS as a Candidate Target for Hypertension.
Background: Hypertension (HTN) is a major cardiovascular risk factor and a leading cause of premature death, affecting ~30% of the global population. Despite available treatments,...
Abstract 4365942: Advanced Diagnosis of Hypertrophic Cardiomyopathy with AI-ECG and Differences Based on Race and Subtype
Background: Hypertrophic cardiomyopathy (HCM) often presents later in the disease course, with frequent delays in diagnoses, high rates of misdiagnoses, and underdiagnosis on a pop...
Abstract 4373702: Fetal left ventricular outflow tract obstruction and placental syncytiotrophoblast differentiation
Introduction: Placental dysfunction is an emerging contributor to neonatal morbidity and mortality in pregnancies complicated by fetal congenital heart disease (CHD). Previous work...
Abstract 4361549: Serine Synthesis Pathway Controls Cardiac Induction of Human Pluripotent Stem Cells
Introduction: With the growing understanding of cell fate decisions, metabolism is increasingly recognized as a potential signaling axis in developmental regulation. Human pluripot...
Abstract 4369846: Symptoms and Reduced Quality-of-Life Measures Correlate with Reduced Myocardial Oxygen Extraction in Atrial Fibrillation
Introduction: Atrial fibrillation (AF) is associated with decreased cardiac output through loss of atrial contribution to ventricular filling and irregular and often rapid ventricu...
Abstract 4372844: Genomic Insights into Tachycardia-Mediated Cardiomyopathy: The Impact of TTN Truncating Variants
Background: Truncating variants in the TTN gene (TTNtv) are the most common genetic cause of non-ischemic (dilated) cardiomyopathy (CM) and are implicated in atrial fibrillation (A...
Abstract 4371106: Artificial Intelligence-Based Machine Learning to Understand the Future of Declining Myocardial Infarction-Related Mortality in the United States: A Time Series Modeling Approach
Introduction: CDC data indicate a steady decline in myocardial infarction (MI) mortality in the U.S. over the past 25 years. This study aims to forecast future MI mortality trends...
Abstract 4358919: Apical sparing of echocardiographic strain in transthyretin amyloidosis is not explained by reduced infiltration of amyloid as determined by technetium-99m pyrophosphate uptake
Background: Cardiac amyloidosis is classically described as having an apical sparing pattern by strain calculations on transthoracic echocardiography (TTE) which has been attribute...
Abstract 4365616: Premature Aging is Associated with Abnormal Cardiac Function in Perinatally HIV-Infected Young Adults
Introduction: Children and adolescents with perinatally acquired HIV (PHIV) are now surviving into adulthood due to improved antiretroviral therapy. However, many still face an inc...
Abstract 4363409: Visceral adipose tissue accumulation is associated with incident fatal and non-fatal cardiovascular events: evidence from population-based cohorts in Latin America
Introduction: Visceral adipose tissue (VAT) is a key contributor to adverse cardiometabolic outcomes. However, its direct measurement via imaging techniques is costly and impractic...
Abstract 4366754: Short-term Particulate Matter 2.5 Exposure and Chronic Psychosocial Stress Cause Maladaptive Remodeling in the Heart.
Background: Cardiovascular disease (CVD) remains the leading cause of death in the U.S., with major influence by environmental factors (Particulate Matter PM 2....
Abstract 4369051: Deep Learning-Guided CT Image Analysis Quantifies 18-Month Changes in Regional Muscle Atrophy in Patients with Peripheral Artery Disease
Introduction: Peripheral artery disease (PAD) is characterized by atherosclerosis of lower extremity arteries that promotes reduced muscle perfusion and skeletal muscle atrophy, wh...
Abstract 4366574: Where You Live Matters: Regional Inequalities in Cor Pulmonale Hospitalizations from 2010-2020
Introduction: Cor Pulmonale (CP) is a potentially life-threatening condition characterized by an enlarged right ventricle that could ultimately lead to failure of the right heart....
Abstract 4365637: Healthcare Resource Utilization and Costs Before and After Evolocumab Initiation Among Patients With Atherosclerotic Cardiovascular Disease: A Real-World Administrative Claims Analysis
Background: Low-density lipoprotein cholesterol (LDL-C) is an independent risk factor associated with atherosclerotic cardiovascular disease (ASCVD) and related morbidity, mortalit...
Abstract 4363407: Electroanatomic Mapping and Intracardiac Echocardiography, an Evolving Experience for Endomyocardial Biopsies
Background: Electroanatomic mapping (EAM) guidance for endomyocardial biopsies (EMB) has been suggested to be feasible and safe, but the diagnostic yield remains unclear for cardio...
Abstract 4366346: Mitral Valve-in-Valve in Rheumatic Heart Disease: Challenges in the Presence of Severe Calcification of the Surgical Bioprosthesis
Introduction: Patients with rheumatic heart disease (RHD) who undergo surgical early mitral valve replacement (MVR) may later require reintervention. Transcatheter mitral valve-in-...
Abstract 4362152: Preoperative Blood Biomarkers Outperform Clinical Variables in Predicting Poor Outcome After Neonatal Cardiopulmonary Bypass Surgery
Introduction: Neonates undergoing surgery for congenital heart disease (CHD) are at risk of death, longer intensive care unit (ICU) stays, and readmissions. Current prognostic mode...
Abstract 4368175: GLP-1 Analogues and Cardiovascular Outcomes in Heart Failure Patients: A Network Meta-Analysis
Background: Heart failure affects over 56 million globally, with sodium-glucose cotransporter-2 (SGLT2) inhibitors now integral to guideline-directed therapy. While glucagon-like p...
Abstract 4357670: Abnormal Oxygen Pulse Trajectory Differentiates Anatomic Complexity and Functional Classification in Adults with Congenital Heart Disease
Background: Cardiopulmonary exercise testing (CPET) including measures of peak oxygen consumption (V O2peak ) and peak oxygen pulse (O...