Circulation
Articles in this Issue
Abstract 4367786: Countywide Burden of Sudden Death Caused by Aortic Dissection and Rupture: From the POstmortem Systematic InvesTigation of Sudden Cardiac Death (POST SCD) Study
Background: The total burden of lethal acute aortic dissection (AD) and subsequent aortic rupture causing sudden cardiac death (SCD) is unknown as previous SCD studies presume card...
Abstract 4359695: Left Main Coronary Artery Obstruction from Mediastinal Mass: High-Risk PCI as Salvage Therapy
Description of Case: A 76-year-old female with a past medical history including HTN, DM, HLD, bilateral breast cancer (status post bilateral mastectomy and radiation), and prior th...
Abstract Sun704: Identifying Resuscitative Transesophageal Echo Targets to Improve CPR Quality and Resuscitation
Background: Resuscitative Transesophageal Echo (rTEE) may enhance CPR quality and identify reversible causes impacting survival....
Abstract 4366984: Targeting the Extracellular cAMP Pathway in Idiopathic Pulmonary Fibrosis
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival period of 3-5 years from the onset of respiratory symptoms. The hallmark of IPF...
Abstract 4365576: Forecasting Ischemic Heart Disease Burden in Southeast Asia: A Temporal Trend Analysis from 1990 to 2019 and Projections to 2050: A Bayesian Age-Period-Cohort Modelling from GBD 2021 Study
Background: Ischemic heart disease (IHD) remains the leading cause of mortality worldwide, with a rising toll in low- and middle- income countries. Southeast Asia, which is undergo...
Abstract 4368371: Efficacy of Sodium-Glucose cotransporter 2 Inhibitors among Cardiac Amyloidosis patients: A Meta-analysis
Background: Sodium-glucose cotransporter 2 inhibitor has shown its cardio-renal protective effects in previous clinical studies. However, its effect on cardiac amyloidosis patients...
Abstract 4366518: Disparities and Trends of Myocardial Infarction-Associated Hospitalizations in the United States
Background: Cardiovascular disease is one of the leading causes of hospitalizations in the United States. However, the prevalence of those hospitalized due to myocardial infarction...
Abstract 4362599: Demographics and Disparity Trends of Cardiovascular Death in Older Adults in the United States: Insights from CDC-wonder Database 1999–2020
Background: Cardiovascular diseases include a range of disorders damaging the heart and blood vessels, including coronary artery disease, cerebrovascular disease, rheumatic heart d...
Abstract 4371006: Identification of High Risk Cases in Coronary Artery Calcium (CAC) Scans based on CAC Score and AI-driven Cardiometabolic Biomarkers: An AI-CVD Study within the Multi-Ethnic Study of Atherosclerosis (MESA)
Introduction: Coronary artery calcium (CAC) scans contain more information than currently reported. The AI-CVD initiative aims to extract actionable opportunististic infomration fr...
Abstract 4354328: What’s On Shelf Shapes What’s in Heart: Retail Food Environment and County-Level Cardiac Mortality in the United States, A Nationwide Ecological Study
Background: Emerging evidence links the local food environment to chronic disease outcomes, yet its relationship with cardiac mortality remains under explored at the population lev...
Abstract 4371376: Real-World Effectiveness of Intravenous Iron Therapy in HFrEF: A Multicenter Propensity-Matched Study
Background: Randomized trials, including AFFIRM-AHF, show that intravenous (IV) iron improves functional status and reduces hospitalizations in patients with heart failure with red...
Abstract 4361781: Evaluation of the PREVENT Risk Assessment Tool and Visceral Adiposity: Insights from the UK Biobank
Background: Visceral adipose tissue (VAT) is a metabolically active fat depot strongly associated with cardiometabolic disease. This study evaluates whether MRI-derived VAT enhance...
Abstract 4366932: AI-CVD vs. PREVENT for Predicting Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis (MESA)
Background: The AI-CVD initiative aims to extract opportunistic screening information from coronary artery calcium (CAC) scans to maximize cardiovascular disease prediction beyond...
Abstract 4368999: Evidence for Decreased Cardiomyocyte Proliferation in Infants with Heart Disease and the Potential for Therapeutic Reversal
Background: Cardiomyocyte proliferation, the fundamental mechanism of heart development and regeneration, is active in infants. We investigated cardiomyocyte proliferation in infan...
Abstract 4365035: Association of SGLT2 Inhibitor Use with Clinical Outcomes in Patients with Tricuspid Regurgitation in the Absence of Left Ventricular Systolic Dysfuncton: A Propensity Score-Matched Analysis
Introduction: Tricuspid Regurgitation (TR) is a valvular disorder associated with significant morbidity and mortality, with current therapeutic options centered on symptom control...
Abstract 4357549: Multi-Center Validation of a Non-exercise Machine Learning Prediction Model Equivalent to Cardiopulmonary Exercise Parameters in Cardiovascular Patients
Background: A symptom-limited incremental cardiopulmonary exercise testing (CPET) is rigidly applied to patients with cardiovascular disease for assessing exercise capacity and pro...
Abstract 4363371: Can a Deep Learning-Based Model Effectively Differentiate Cardiac Congestion and Interstitial Lung Disease in Patients With Acute Dyspnea Using Chest Radiography?
Background: Differentiating the underlying cause of dyspnea in patients presenting to the emergency department is sometimes a clinical challenge. It is often difficult to distingui...
Abstract 4361107: Pulmonary Hypertension is associated with higher In-Hospital Complications After Transcatheter Mitral Valve Intervention- A Nationwide Analysis of 73,000 Patients
Background: Pulmonary hypertension (PH) is commonly associated with mitral valve disease. Transcatheter mitral valve repair (TMVR), involves transseptal approach to replace the dis...
Abstract 4366409: Linking variability of leukocyte lipid metabolism to circulating lipids, lipoprotein composition and cardiovascular risk in the Finnish adult population
Background: Interindividual differences for outcomes of lipid-lowering therapy are well known. Here we aimed to characterize how alterations in cellular lipid uptake, storage and u...
Abstract 4363020: Higher Neighborhood Social Vulnerability is Associated with Lower Life’s Essential 8 Cardiovascular Health Scores: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Background: The CDC Social Vulnerability Index (SVI) quantifies community-level social vulnerability across four domains: socioeconomic (SES), household characteristics (e.g., sing...
Abstract 4352387: Association of METS-IR and Subclinical Myocardial Injury with Cardiovascular Mortality in U.S. Adults
Background: The Metabolic Score for Insulin Resistance (METS-IR), a non-insulin-based surrogate for insulin resistance (IR), and subclinical myocardial injury (SCMI), defined by ab...
Abstract 4340812: Branch vs septum: A meta analysis of ventricular synchrony in Left bundle branch pacing vs left ventricular septal pacing with subgroup analysis based on baseline LVEF.
INTRODUCTION: Novel pacing methods including left bundle branch pacing(LBBP) and left ventricular septal pacing(LVSP) are being used to improve ventricular conduction and synchroni...
Abstract 4364397: Safety and Tolerability of REGN5381, a Monoclonal Antibody Agonist of NPR1 in Patients With Heart Failure With Reduced Ejection Fraction
Introduction: Heart failure with reduced ejection fraction (HFrEF) causes high morbidity and mortality despite available therapies, indicating an unmet medical need. Activation of...
Abstract 4366972: Endurance Exercise Modifies Organ-Specific Proteomic Aging Scores: Insights from the Heritage Family Study
Introduction: Plasma proteomics has been used to identify organ-specific aging signatures related to health and disease. It is unknown whether regular exercise can modulate predict...
Abstract 4360319: Digital Twin Matching for Real-World Cardiometabolic Medication Effect Estimation using Genomically informed Longitudinal Bayesian Disease Trajectories
Background: Confounding differences between treated and untreated patients in observational studies of medication effects lead to biased estimates of drug effectiveness and safety....