Circulation
Articles in this Issue
Abstract 4367206: Comparison of Long-Term Outcomes With Metoprolol vs Carvedilol in Women With Peripartum Cardiomyopathy: A Propensity-Matched Analysis
Background: Beta-adrenergic blockers are commonly prescribed in the management of peripartum cardiomyopathy (PPCM) during the postpartum period. However, real-world data directly c...
Abstract 4347046: Uncovering the Mechanistic Linkage Between Parasympathetic Nerve Activity and Overlying Complex Fractionated Atrial Electrograms in the Development of Persistent Atrial Fibrillation
Background: The mechanistic linkage of complex fractionated atrial electrograms (CFAEs) and the relationship with the autonomic nervous system in the development of persistent atri...
Abstract 4370614: The Prognostic Value of Modified Frailty Index in Complications and Survival Following Percutaneous Coronary Interventions: A Data-Driven Approach
Introduction: Frailty is a critical condition characterized by reduced physiological reserve. The modified Frailty Index (MFI-5) is a comorbidity-based tool that assesses five heal...
Abstract Sun606: Assessment of Racial Bias in Cerebral Oximetry During Cardiac Arrest: An Ancillary Analysis of the AWARE II Study
Background: Cerebral oximetry is a tool to assess the quality of resuscitation and to predict the return of ROSC and survival with neurological outcomes. The use of near-infrared s...
Abstract 4370644: Rising Heat, Falling Cold: Three-Decade Shifts in Cardiovascular Mortality Among Youth Attributable to Non-Optimal Temperature Exposure Across 204 Countries
Background: Non-optimal temperatures have become silent amplifiers of cardiovascular(CV) risk, yet their impact on individuals <20 remains underrecognized. Children and adolesce...
Abstract 4362767: Combination therapy with phosphodiesterase 5 and neprilysin inhibitors synergistically offsets the development of heart failure with reduced ejection fraction
Background: Cyclic GMP (cGMP) preserves cardiac structure and function, and impaired cGMP signaling contributes to the pathogenesis of heart failure with reduced ejection fraction...
Abstract 4367016: Double Trouble - Type A Dissection Complicating an Already Complicated Pregnancy
Introduction: Acute aortic dissection during pregnancy is rare but often life-threatening. Hormonal and hemodynamic changes, including increased blood volume and cardiac output, ca...
Abstract 4369577: Patient-Specific Ascending Aortic Wall Shear Stress and Strain Analysis from 4D CT
Introduction: Hemodynamics and wall biomechanics jointly drive ascending-aortic remodeling in bicuspid aortic valve (BAV) disease, yet most in silico studies model only flow or str...
Abstract 4368674: Tension in the Air - Cardiac Tamponade Secondary to Tension Pneumomediastinum
Intro: Cardiac tamponade is a common cause of obstructive shock, often necessitating urgent intervention. We delineate a rare case of cardiac tamponade and shock due to tension pne...
Abstract 4370619: When Bigger Isn’t Worse: The Obesity Paradox in Pulmonary Embolism — A Meta-Analysis
Background: Obesity is a well-established risk factor for venous thromboembolism, including pulmonary embolism (PE). Obese individuals are more likely to develop PE due to prothrom...
Abstract 4364782: Machine Learning–Based Risk Stratification in Hypertrophic Cardiomyopathy: The Added Prognostic Value of Combined Cardiopulmonary Exercise Testing and Stress Echocardiography
Introduction: Hypertrophic cardiomyopathy (HCM) is a genetically mediated myocardial disorder with variable clinical expression and reduced functional capacity....
Abstract Sun1108: Development of a Novel Categorization Framework for In-Hospital Cardiac Arrest
Introduction: In-hospital cardiac arrest (IHCA) affects roughly 300,000 patients each year in the United States. Compared to out-of-hospital cardiac arrest (OHCA), IHCA remains und...
Abstract 4363338: B-type Natriuretic Peptide Reverses Vascular Endothelial Insulin Resistance and Ameliorates Oxidative Stress in Human Atherosclerosis
Aim: Patients with atherosclerosis and type 2 diabetes (T2DM) on aggressive insulin therapy have poor cardiovascular outcomes. Atherosclerosis patients with and without T2DM exhibi...
Abstract 4354903: Pulsed Field Ablation for the Treatment of Octogenarians with Atrial Fibrillation
Background: Pulsed field ablation (PFA) for atrial fibrillation (AF) has demonstrated comparable treatment efficacy with conventional thermal ablation. Despite its high safety prof...
Abstract 4359600: Renal Dysfunction and Health-Related Quality of Life in Heart Failure: A Mediation Analysis of Patient-Centered Outcomes
Background: Heart failure (HF) is a condition frequently complicated by renal dysfunction, which can significantly impair patients' health-related quality of life (HRQoL). Although...
Abstract 4369053: Coronary Artery Calcium Score Modifies the Risk of Coronary Heart Disease Associated with Apolipoprotein B
Introduction: Apolipoprotein B (ApoB) and coronary artery calcium score (CAC) are well-established risk factors for coronary heart disease (CHD). However, the interaction between t...
Abstract 4368574: Cardiovascular Events in Hospitalized Patients with Malignant Neuroendocrine Tumors: A Nationwide Analysis
Background: Malignant neuroendocrine tumors (NET) are associated with systemic effects that may predispose patients to cardiovascular complications. However, the burden and outcome...
Abstract 4368879: Indoor Air Pollutants and Heart Health in a Cohort of Older Adults
Introduction/Background: The impact of exposure to air pollution (AP) in the home on cardiovascular health is limited because most data is based on outdoor exposure. This is an imp...
Abstract 4365263: Prognostic Impact of Left Atrial and Left Ventricular Strain in Patients with Atrial Fibrillation
Introduction: Atrial fibrillation (AF) serves both as a cause and a perpetuating factor in the progression of heart failure (HF). While left ventricular (LV) and left atrial (LA) d...
Abstract 4366761: Catheter Ablation versus Antiarrhythmic Drugs for Ventricular Tachycardia: A Systematic Review and Meta-Analysis
Background: Sustained ventricular tachycardia (VT) and fibrillation-related sudden cardiac death (SCD) account for nearly 450,000 deaths annually in the United States. Catheter abl...
Abstract 4340802: Right Ventricular Longitudinal Strain Indexed to Right Ventricular Systolic Pressure for Detecting Right Ventricular-Pulmonary Artery Uncoupling and Mortality in Pulmonary Hypertension Patients
Background: A key determinant of prognosis in pulmonary hypertension (PH) is the right ventricle’s (RV) ability to adapt to increased pulmonary vascular resistance. Consequently, m...
Abstract 4366250: Targeting SIN3a-Mediated FOXK2 Regulation to Restore BMPR2 Expression and Reverse Endothelial Dysfunction in Pulmonary Arterial Hypertension
Background: Pulmonary Arterial Hypertension (PAH) is a rare, progressive lung disease with limited treatment options. Loss of BMPR2 expression is a well-established contributor to...
Abstract 4368317: Identifying cardioprotective strategies against DOX-induced cardiotoxicity using mature, mitochondrial-rich and patient-derived hiPSC-cardiomyocytes
Introduction: Doxorubicin (DOX) is widely used in cancer treatment but may cause mitochondrial damage and cardiotoxicity. Dexrazoxane is the only clinically approved intervention f...
Abstract 4367274: Invasive Hemodynamic and MRI Predictors of High Risk Lymphatic Subtype T2-Weighted Pre-Fontan MRI and Associated Clinical Outcomes
Background: Lymphatic subtype (LS) 4, as identified on T2-weighted cardiac MRI (CMR), is associated with higher rates of Fontan failure. Pre-Fontan factors predictive of LS are inc...
Abstract 4343109: Prevalence Of Heart Tumors And Their Prognostic Factors (2000-2020): An Analysis Of The U.S. Seer Database
Background: Heart tumors pose significant diagnostic and therapeutic challenges. Understanding their prevalence and prognostic factors is crucial for improving patient outcomes....